{"id":9714,"date":"2026-04-14T10:30:24","date_gmt":"2026-04-14T10:30:24","guid":{"rendered":"https:\/\/sepro.vn\/?p=9714"},"modified":"2026-07-23T07:27:22","modified_gmt":"2026-07-23T00:27:22","slug":"quaternary-ammonium-compounds-quats-phong-sach","status":"publish","type":"post","link":"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/","title":{"rendered":"Quaternary Ammonium Compounds (QUATs) Ki\u1ec3m So\u00e1t Vi Sinh: Gi\u1ea3i Ph\u00e1p Lu\u00e2n Phi\u00ean B\u1ec1n V\u1eefng C\u00f9ng SEPRO"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_62 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#QUATs_Quaternary_Ammonium_Compounds_La_Gi_Va_Tai_Sao_No_Pho_Bien_Trong_Phong_Sach\" title=\"QUATs (Quaternary Ammonium Compounds) L\u00e0 G\u00ec V\u00e0 T\u1ea1i Sao N\u00f3 Ph\u1ed5 Bi\u1ebfn Trong Ph\u00f2ng S\u1ea1ch\">QUATs (Quaternary Ammonium Compounds) L\u00e0 G\u00ec V\u00e0 T\u1ea1i Sao N\u00f3 Ph\u1ed5 Bi\u1ebfn Trong Ph\u00f2ng S\u1ea1ch<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Hieu_Qua_va_Khong_Hieu_Qua_Voi_Cac_Loai_Vi_Sinh_Nao\" title=\"Hi\u1ec7u Qu\u1ea3 v\u00e0 Kh\u00f4ng Hi\u1ec7u Qu\u1ea3 V\u1edbi C\u00e1c Lo\u1ea1i Vi Sinh N\u00e0o ?\">Hi\u1ec7u Qu\u1ea3 v\u00e0 Kh\u00f4ng Hi\u1ec7u Qu\u1ea3 V\u1edbi C\u00e1c Lo\u1ea1i Vi Sinh N\u00e0o ?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Khi_Nao_Nen_Dung_Trong_Chuong_Trinh_Kiem_Soat_Vi_Sinh\" title=\"Khi N\u00e0o N\u00ean D\u00f9ng Trong Ch\u01b0\u01a1ng Tr\u00ecnh Ki\u1ec3m So\u00e1t Vi Sinh\">Khi N\u00e0o N\u00ean D\u00f9ng Trong Ch\u01b0\u01a1ng Tr\u00ecnh Ki\u1ec3m So\u00e1t Vi Sinh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Nhung_Han_Che_Va_Sai_Lam_Khi_Su_Dung_%E2%80%94_Biofilm_Khang_Hoa_Chat_Moi_Truong\" title=\"Nh\u1eefng H\u1ea1n Ch\u1ebf V\u00e0 Sai L\u1ea7m Khi S\u1eed D\u1ee5ng \u2014 Biofilm, Kh\u00e1ng H\u00f3a Ch\u1ea5t, M\u00f4i Tr\u01b0\u1eddng\">Nh\u1eefng H\u1ea1n Ch\u1ebf V\u00e0 Sai L\u1ea7m Khi S\u1eed D\u1ee5ng \u2014 Biofilm, Kh\u00e1ng H\u00f3a Ch\u1ea5t, M\u00f4i Tr\u01b0\u1eddng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Quaternary_Ammonium_Compounds_QACs_Trong_Chuong_Trinh_Luan_Phien_Hoa_Chat\" title=\"Quaternary Ammonium Compounds (QACs) Trong Ch\u01b0\u01a1ng Tr\u00ecnh Lu\u00e2n Phi\u00ean H\u00f3a Ch\u1ea5t\">Quaternary Ammonium Compounds (QACs) Trong Ch\u01b0\u01a1ng Tr\u00ecnh Lu\u00e2n Phi\u00ean H\u00f3a Ch\u1ea5t<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Cach_dien_dat_ngan_gon_de_dua_vao_SOP\" title=\"C\u00e1ch di\u1ec5n \u0111\u1ea1t ng\u1eafn g\u1ecdn \u0111\u1ec3 \u0111\u01b0a v\u00e0o SOP\">C\u00e1ch di\u1ec5n \u0111\u1ea1t ng\u1eafn g\u1ecdn \u0111\u1ec3 \u0111\u01b0a v\u00e0o SOP<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Ket_qua_van_hanh_dat_duoc\" title=\"K\u1ebft qu\u1ea3 v\u1eadn h\u00e0nh \u0111\u1ea1t \u0111\u01b0\u1ee3c\">K\u1ebft qu\u1ea3 v\u1eadn h\u00e0nh \u0111\u1ea1t \u0111\u01b0\u1ee3c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Tai_Sao_Ket_Hop_La_Giai_Phap_Dung\" title=\"T\u1ea1i Sao K\u1ebft H\u1ee3p L\u00e0 Gi\u1ea3i Ph\u00e1p \u0110\u00fang?\">T\u1ea1i Sao K\u1ebft H\u1ee3p L\u00e0 Gi\u1ea3i Ph\u00e1p \u0110\u00fang?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#FAQs_%E2%80%93_Quaternary_Ammonium_Compounds_QACs\" title=\"FAQs &#8211; Quaternary Ammonium Compounds (QACs)\">FAQs &#8211; Quaternary Ammonium Compounds (QACs)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/#Tam_Ket\" title=\"T\u1ea1m K\u1ebft\">T\u1ea1m K\u1ebft<\/a><\/li><\/ul><\/nav><\/div>\n<p><span style=\"font-weight: 400;\">Trong th\u1ef1c t\u1ebf v\u1eadn h\u00e0nh t\u1ea1i c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c, \u0111\u00e3 ghi nh\u1eadn hi\u1ec7n t\u01b0\u1ee3ng gia t\u0103ng vi sinh sau m\u1ed9t th\u1eddi gian s\u1eed d\u1ee5ng <strong>QUATs<\/strong> \u0111\u1ec3 ki\u1ec3m so\u00e1t vi sinh <strong>li\u00ean t\u1ee5c<\/strong>. Nguy\u00ean nh\u00e2n th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn chi\u1ebfn l\u01b0\u1ee3c lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t trong ch\u01b0\u01a1ng tr\u00ecnh kh\u1eed khu\u1ea9n.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0110\u00e1nh gi\u00e1 th\u1ef1c t\u1ebf cho th\u1ea5y d\u01b0 l\u01b0\u1ee3ng c\u00f2n l\u1ea1i sau khi s\u1eed d\u1ee5ng Quaternary Ammonium Compounds <strong>d\u1ec5 b\u1ecb t\u00edch t\u1ee5 tr\u00ean b\u1ec1 m\u1eb7t c\u00f3 th\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi sinh v\u1eadt th\u00edch nghi<\/strong>, <strong>l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t theo th\u1eddi gian<\/strong>. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n kh\u00f4ng ch\u1ec9 ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i h\u00f3a ch\u1ea5t m\u00e0 c\u00f2n <strong>ph\u1ee5 thu\u1ed9c v\u00e0o c\u00e1ch s\u1eed d\u1ee5ng v\u00e0 chi\u1ebfn l\u01b0\u1ee3c ki\u1ec3m so\u00e1t.<\/strong><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Th\u00f4ng qua b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/sepro.vn\/\"><strong>SEPRO<\/strong><\/a> s\u1ebd tr\u00ecnh b\u00e0y c\u00e1c sai s\u00f3t th\u01b0\u1eddng g\u1eb7p v\u00e0 nguy\u00ean t\u1eafc s\u1eed d\u1ee5ng <strong>Quaternary Ammonium Compounds (QACs) <\/strong>nh\u1eb1m \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3, an to\u00e0n v\u00e0 t\u00ednh b\u1ec1n v\u1eefng trong ki\u1ec3m so\u00e1t vi sinh.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"QUATs_Quaternary_Ammonium_Compounds_La_Gi_Va_Tai_Sao_No_Pho_Bien_Trong_Phong_Sach\"><\/span><b>QUATs (<span style=\"font-weight: 400;\"><strong>Quaternary Ammonium Compounds<\/strong><\/span>) L\u00e0 G\u00ec V\u00e0 T\u1ea1i Sao N\u00f3 Ph\u1ed5 Bi\u1ebfn Trong Ph\u00f2ng S\u1ea1ch<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<figure id=\"attachment_9718\" aria-describedby=\"caption-attachment-9718\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-9718\" src=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/2-3.png\" alt=\"quat-la-gi\" width=\"600\" height=\"600\" srcset=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/2-3.png 600w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/2-3-300x300.png 300w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/2-3-150x150.png 150w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/2-3-100x100.png 100w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9718\" class=\"wp-caption-text\"><em>QUATs L\u00e0 G\u00ec ?<\/em><\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Khi n\u00f3i \u0111\u1ebfn ki\u1ec3m so\u00e1t vi sinh ph\u00f2ng s\u1ea1ch, <strong>Quaternary Ammonium Compounds (QACs)<\/strong>, hay <strong><a href=\"https:\/\/sepro.vn\/vi\/vi-tri-cua-hop-chat-amoni-bac-bon-trong-nganh-duoc\/\">h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n<\/a><\/strong> l\u00e0 lo\u1ea1i h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n m\u1ea1nh m\u1ebd c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t vi khu\u1ea9n, virus v\u00e0 n\u1ea5m m\u00e0 c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c th\u01b0\u1eddng xuy\u00ean s\u1eed d\u1ee5ng trong ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh h\u00e0ng ng\u00e0y.\u00a0<\/span><\/p>\n<h3><b>Nh\u01b0ng th\u1ef1c s\u1ef1 <span style=\"font-weight: 400;\"><strong>Quaternary Ammonium Compounds (QACs) <\/strong><\/span>l\u00e0 g\u00ec?<\/b><\/h3>\n<p><strong>L\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n (amoni b\u1eadc b\u1ed1n)<\/strong><span style=\"font-weight: 400;\">, \u0111\u01b0\u1ee3c c\u1ea5u t\u1ea1o t\u1eeb m\u1ed9t nguy\u00ean t\u1eed nit\u01a1 \u0111\u01b0\u1ee3c li\u00ean k\u1ebft v\u1edbi 4 nh\u00f3m alkyl. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng r\u1ea5t \u0111\u01a1n gi\u1ea3n: <\/span><\/p>\n<blockquote><p><span style=\"font-weight: 400;\">Amoni b\u1eadc 4 mang <strong>\u0111i\u1ec7n t\u00edch d\u01b0\u01a1ng (+)<\/strong> s\u1ebd b\u1ecb h\u00fat v\u00e0o m\u00e0ng t\u1ebf b\u00e0o vi khu\u1ea9n mang <strong>\u0111i\u1ec7n t\u00edch \u00e2m (\u2212)<\/strong>, x\u00e2m nh\u1eadp v\u00e0o l\u1edbp lipid bilayer, <strong>ph\u00e1 v\u1ee1 c\u1ea5u tr\u00fac v\u00e0 g\u00e2y r\u00f2 r\u1ec9 n\u1ed9i b\u00e0o<\/strong>.\u00a0<\/span><\/p><\/blockquote>\n<p><span style=\"font-weight: 400;\">Phi\u00ean b\u1ea3n m\u1edbi nh\u1ea5t l\u00e0 th\u1ebf h\u1ec7 th\u1ee9 5, \u0111\u01b0\u1ee3c c\u1ea3i ti\u1ebfn \u0111\u1ec3 kh\u00f4ng g\u00e2y \u0103n m\u00f2n, pH trung t\u00ednh, v\u00e0 d\u1ec5 r\u1eeda s\u1ea1ch kh\u1ecfi b\u1ec1 m\u1eb7t.<\/span><\/p>\n<h3><b>T\u1ea1i sao<span style=\"font-weight: 400;\"><strong>\u00a0<\/strong><\/span>l\u1ea1i ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf kh\u1eed khu\u1ea9n ph\u00f2ng s\u1ea1ch?\u00a0<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Khi so s\u00e1nh gi\u1eefa nhi\u1ec1u lo\u1ea1i h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n, Quaternary Ammonium Compounds (QACs) \u0111\u01b0\u1ee3c \u01b0u ti\u00ean l\u1ef1a ch\u1ecdn nh\u1edd <strong>chi ph\u00ed th\u1ea5p, \u00e1p d\u1ee5ng \u0111\u01b0\u1ee3c cho c\u1ea3 v\u1ec7 sinh v\u00e0 kh\u1eed khu\u1ea9n h\u1eb1ng ng\u00e0y, m\u1ee9c \u0111\u1ed9 \u0103n m\u00f2n th\u1ea5p v\u00e0 \u0111\u1ed9 an to\u00e0n t\u01b0\u01a1ng \u0111\u1ed1i \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi s\u1eed d\u1ee5ng,<\/strong> t\u00f9y thu\u1ed9c v\u00e0o n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111i\u1ec1u ki\u1ec7n \u00e1p d\u1ee5ng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Do \u0111\u00f3, <strong>Quaternary Ammonium Compounds (QACs) th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n ch\u00ednh<\/strong> trong ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh \u0111\u1ecbnh k\u1ef3 t\u1ea1i <strong>c\u00e1c khu v\u1ef1c Grade C v\u00e0 D<\/strong> trong nh\u00e0 m\u00e1y D\u01b0\u1ee3c (PHARMACEUTICALS).<\/span><\/p>\n<h3><b>So s\u00e1nh nhanh: QUATs vs Alcohol vs H2O2 (HYDROGEN PEROXIDE 6%)<\/b><\/h3>\n<table>\n<tbody>\n<tr>\n<td><b>Ti\u00eau Ch\u00ed<\/b><\/td>\n<td><b>QUATs<\/b><\/td>\n<td><b>Alcohol (IPA\/Ethanol)<\/b><\/td>\n<td><b>H2O2 6%<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Contact Time<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10-15 ph\u00fat<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2-10 ph\u00fat<\/span><\/td>\n<td><span style=\"font-weight: 400;\">20-30 ph\u00fat<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Gram D\u01b0\u01a1ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao (&gt;4 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao (&gt;4 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao (&gt;4 log)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Gram \u00c2m<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p (30-50%)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p (30-50%)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao (&gt;4 log)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">N\u1ea5m<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Trung b\u00ecnh<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Virus C\u00f3 V\u1ecf Lipid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Trung b\u00ecnh<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Virus Kh\u00f4ng V\u1ecf<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">B\u00e0o T\u1eed<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">D\u01b0 L\u01b0\u1ee3ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">C\u00f3 (c\u1ea7n r\u1eeda WFI)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng (bay h\u01a1i)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng (ph\u00e2n h\u1ee7y)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Chi Ph\u00ed<\/span><\/td>\n<td><span style=\"font-weight: 400;\">R\u1ebb<\/span><\/td>\n<td><span style=\"font-weight: 400;\">R\u1ebb-Trung b\u00ecnh<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Trung b\u00ecnh-\u0110\u1eaft<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">\u0102n M\u00f2n V\u1eadt Li\u1ec7u<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng (pH trung t\u00ednh)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">C\u00f3 (ethanol)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ph\u00f9 H\u1ee3p<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Grade C\/D<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Grade B\/C<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Grade A\/B<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"Hieu_Qua_va_Khong_Hieu_Qua_Voi_Cac_Loai_Vi_Sinh_Nao\"><\/span><b>Hi\u1ec7u Qu\u1ea3 v\u00e0 Kh\u00f4ng Hi\u1ec7u Qu\u1ea3 V\u1edbi C\u00e1c Lo\u1ea1i Vi Sinh N\u00e0o ?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Khi b\u1eaft \u0111\u1ea7u ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m so\u00e1t vi sinh, m\u1ed9t nh\u00e2n vi\u00ean QA\/QC th\u01b0\u1eddng h\u1ecfi: <strong><a href=\"https:\/\/sepro.vn\/vi\/tac-dong-cua-quat-tren-biofilm-va-vi-sinh\/\">&#8220;H\u00f3a ch\u1ea5t c\u00f3 th\u1ef1c s\u1ef1 di\u1ec7t \u0111\u01b0\u1ee3c t\u1ea5t c\u1ea3 vi sinh kh\u00f4ng?&#8221; <\/a><\/strong><\/span><\/p>\n<p><span style=\"font-weight: 400;\">C\u00e2u tr\u1ea3 l\u1eddi kh\u00f4ng mang t\u00ednh tuy\u1ec7t \u0111\u1ed1i, m\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a c\u00e1c ch\u1ee7ng vi sinh c\u00f3 trong m\u00f4i tr\u01b0\u1eddng ph\u00f2ng s\u1ea1ch.<\/span><\/p>\n<h3><b><span style=\"font-weight: 400;\"><strong>Quaternary Ammonium Compounds (QACs) <\/strong><\/span>hi\u1ec7u qu\u1ea3 v\u1edbi lo\u1ea1i vi sinh n\u00e0o?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">QUATs c\u00f3 hi\u1ec7u qu\u1ea3 cao tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i t\u1ef1 do (planktonic), th\u01b0\u1eddng \u0111\u1ea1t \u22654 log reduction (\u226599,99%), bao g\u1ed3m c\u00e1c ch\u1ee7ng nh\u01b0 Staphylococcus aureus v\u00e0 Bacillus subtilis ATCC 6633. Th\u1eddi gian ti\u1ebfp x\u00fac ch\u1ec9 c\u1ea7n 10-15 ph\u00fat v\u1edbi n\u1ed3ng \u0111\u1ed9 0.5-1%.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">N\u00f3 c\u0169ng di\u1ec7t \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 n\u1ea5m nh\u01b0 Candida albicans ATCC 10231 (y\u00eau c\u1ea7u 15-20 ph\u00fat), v\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i hi\u1ec7u qu\u1ea3 v\u1edbi virus c\u00f3 v\u1ecf lipid nh\u01b0 coronavirus, influenza (2-10 ph\u00fat).<\/span><\/p>\n<h3><b><span style=\"font-weight: 400;\"><strong>Quaternary Ammonium Compounds (QACs) <\/strong><\/span>k\u00e9m hi\u1ec7u qu\u1ea3 v\u1edbi g\u00ec?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Hi\u1ec7u qu\u1ea3 c\u1ee7a Amoni b\u1eadc 4 s\u1ebd gi\u1ea3m \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi vi khu\u1ea9n Gram \u00e2m (v\u00ed d\u1ee5 Pseudomonas, E. coli) so v\u1edbi vi khu\u1ea9n Gram d\u01b0\u01a1ng ch\u1ec9 c\u00f2n 30-50% kh\u1eed khu\u1ea9n. L\u00fd do l\u00e0 m\u00e0ng ngo\u00e0i c\u1ee7a Gram \u00e2m ch\u1ee9a lipopolysaccharide (LPS) l\u00e0m h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng th\u1ea5m c\u1ee7a Amoniac B\u1eadc 4.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">V\u1edbi biofilm (nh\u1eefng c\u1ed9ng \u0111\u1ed3ng vi sinh b\u00e1m d\u00ednh tr\u00ean b\u1ec1 m\u1eb7t c\u00f3 l\u1edbp ma tr\u1eadn b\u1ea3o v\u1ec7), l\u00e0m h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn c\u1ee7a h\u00f3a ch\u1ea5t. QUATs g\u1ea7n nh\u01b0 kh\u00f4ng c\u00f2n \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Virus kh\u00f4ng c\u00f3 v\u1ecf lipid nh\u01b0 Adenovirus type 5 ATCC VR-5, hepatitis A, norovirus c\u0169ng kh\u00e1ng <strong>Amoni b\u1eadc 4<\/strong> v\u00e0 b\u00e0o t\u1eed vi khu\u1ea9n (Clostridium difficile, Bacillus subtilis ATCC 6633 \u1edf d\u1ea1ng b\u00e0o t\u1eed) ho\u00e0n to\u00e0n kh\u00f4ng b\u1ecb di\u1ec7t b\u1edfi Quaternary Ammonium Compounds \u2014 ch\u00fang c\u1ea7n h\u00f3a ch\u1ea5t di\u1ec7t b\u00e0o t\u1eed nh\u01b0 H2O2 hay PAA ho\u1eb7c h\u00f3a ch\u1ea5t k\u1ebft h\u1ee3p c\u1ea3 2 ho\u1ea1t ch\u1ea5t.<\/span><\/p>\n<h3><b>B\u1ea3ng Ki\u1ec3m So\u00e1t Vi Sinh:<\/b><\/h3>\n<table>\n<tbody>\n<tr>\n<td><b>Y\u1ebfu T\u1ed1<\/b><\/td>\n<td><b>Hi\u1ec7u Qu\u1ea3<\/b><\/td>\n<td><b>L\u01b0u \u00dd<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Planktonic Gram+ (Staph, Bacillus subtilis ATCC 6633 t\u1ef1 do)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao (&gt;4 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Contact time 10-15 ph\u00fat, n\u1ed3ng \u0111\u1ed9 0.5-1%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Biofilm Gram- (Pseudomonas b\u00e1m d\u00ednh)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p (&lt;2 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">C\u1ea7n k\u1ebft h\u1ee3p PAA ho\u1eb7c l\u00e0m s\u1ea1ch c\u01a1 h\u1ecdc tr\u01b0\u1edbc<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">N\u1ea5m (Candida albicans ATCC 10231)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Trung b\u00ecnh (2-3 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Contact time 15-20 ph\u00fat, nh\u1ea1y c\u1ea3m v\u1edbi QUATs<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Virus C\u00f3 V\u1ecf Lipid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao (&gt;3 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Di\u1ec7t nhanh trong 2-10 ph\u00fat<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Virus Kh\u00f4ng V\u1ecf (Adenovirus type 5 ATCC VR-5)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p (&lt;1 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00e1ng QUATs, c\u1ea7n H2O2 ho\u1eb7c PAA<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">B\u00e0o T\u1eed (Bacillus subtilis ATCC 6633 spore)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng (0 log)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ho\u00e0n to\u00e0n kh\u00e1ng, c\u1ea7n Sporicide<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">D\u01b0 l\u01b0\u1ee3ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">C\u00f3 (&gt;2 \u00b5g\/cm\u00b2)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u00e1nh d\u01b0\u1edbi MIC k\u00edch th\u00edch kh\u00e1ng h\u00f3a ch\u1ea5t<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">N\u01b0\u1edbc c\u1ee9ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Gi\u1ea3m 30-50%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">D\u00f9ng WFI thay n\u01b0\u1edbc m\u00e1y<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Monitoring<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Settle plate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;1 CFU\/plate theo GMP Vi\u1ec7t Nam ti\u00eau chu\u1ea9n<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"Khi_Nao_Nen_Dung_Trong_Chuong_Trinh_Kiem_Soat_Vi_Sinh\"><\/span><b>Khi N\u00e0o N\u00ean D\u00f9ng Trong Ch\u01b0\u01a1ng Tr\u00ecnh Ki\u1ec3m So\u00e1t Vi Sinh<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Trong v\u1eadn h\u00e0nh ph\u00f2ng s\u1ea1ch GMP, m\u1ed9t sai s\u00f3t th\u01b0\u1eddng g\u1eb7p l\u00e0 \u00e1p d\u1ee5ng c\u00f9ng m\u1ed9t h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n cho to\u00e0n b\u1ed9 c\u00e1c khu v\u1ef1c m\u00e0 kh\u00f4ng ph\u00e2n bi\u1ec7t m\u1ee9c \u0111\u1ed9 y\u00eau c\u1ea7u ki\u1ec3m so\u00e1t. QUATs ph\u00f9 h\u1ee3p cho c\u00e1c khu v\u1ef1c Grade C v\u00e0 D, bao g\u1ed3m khu ph\u1ee5 tr\u1ee3 v\u00e0 h\u00e0nh lang kho, n\u01a1i kh\u00f4ng ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi s\u1ea3n ph\u1ea9m v\u00e0 c\u00f3 y\u00eau c\u1ea7u ki\u1ec3m so\u00e1t vi sinh \u1edf m\u1ee9c th\u1ea5p h\u01a1n.<\/span><\/p>\n<h3><b><strong>Quaternary Ammonium Compounds (QACs) <\/strong>cho khu v\u1ef1c ph\u00f2ng s\u1ea1ch n\u00e0o?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">L\u00e0 l\u1ef1a ch\u1ecdn t\u1ed1i \u01b0u cho ki\u1ec3m so\u00e1t vi sinh h\u00e0ng ng\u00e0y Grade C, D v\u00e0 c\u00e1c khu v\u1ef1c h\u1ed7 tr\u1ee3, h\u00e0nh lang, kho, ph\u00f2ng nguy\u00ean li\u1ec7u. Amoni b\u1eadc 4 c\u0169ng \u0111\u01b0\u1ee3c d\u00f9ng trong ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh &amp; kh\u1eed khu\u1ea9n h\u1eb1ng ng\u00e0y cho c\u00e1c khu v\u1ef1c ph\u00f2ng s\u1ea1ch khi kh\u00f4ng c\u00f3 s\u1ef1 c\u1ed1.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tuy nhi\u00ean n\u1ebfu mu\u1ed1n s\u1eed d\u1ee5ng \u1edf Grade A (v\u00f9ng s\u1ea3n xu\u1ea5t tr\u1ef1c ti\u1ebfp) th\u00ec ph\u1ea3i k\u1ebft h\u1ee3p s\u1eed d\u1ee5ng th\u00eam h\u00f3a ch\u1ea5t di\u1ec7t \u0111\u01b0\u1ee3c b\u00e0o t\u1eed v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ec7t tr\u00f9ng.<\/span><\/p>\n<h3><b><strong>Quaternary Ammonium Compounds (QACs) <\/strong>d\u00f9ng cho b\u1ec1 m\u1eb7t ph\u00f2ng s\u1ea1ch n\u00e0o?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">S\u00e0n, t\u01b0\u1eddng, b\u00e0n, thau r\u1eeda, d\u1ee5ng c\u1ee5 kh\u00f4ng ti\u1ebfp x\u00fac th\u1ef1c ph\u1ea9m \u2014 nh\u1eefng b\u1ec1 m\u1eb7t n\u00e0y \u0111\u01b0\u1ee3c v\u1ec7 sinh h\u00e0ng ng\u00e0y . Thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t (mixer, m\u00e1y filling) c\u0169ng c\u00f3 th\u1ec3 d\u00f9ng \u0111\u01b0\u1ee3c n\u1ebfu kh\u00f4ng li\u00ean quan tr\u1ef1c ti\u1ebfp \u0111\u1ebfn s\u1ea3n ph\u1ea9m.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nh\u01b0ng n\u1ebfu vi sinh t\u0103ng b\u1ea5t th\u01b0\u1eddng, \u0111\u1eb7c bi\u1ec7t l\u00e0 b\u00e0o t\u1eed \u1edf m\u1ed9t khu v\u1ef1c c\u1ee5 th\u1ec3, <\/span><b>b\u1ea1n c\u1ea7n chuy\u1ec3n sang h\u00f3a ch\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n m\u1ea1nh h\u01a1n nh\u01b0 Sporicide.<\/b><\/p>\n<h3><strong>V\u00ed d\u1ee5 th\u1ef1c t\u1ebf: S\u1eed d\u1ee5ng trong QC\/QA daily checklist<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Ng\u00e0y h\u00f4m nay, b\u1ea1n v\u1eeba v\u00e0o ph\u00f2ng s\u1ea1ch l\u00fac 7 s\u00e1ng. Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u s\u1ea3n xu\u1ea5t, b\u1ea1n:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ki\u1ec3m tra settle plate t\u1eeb h\u00f4m qua \u2192 &lt;1 CFU\/plate \u2713<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Phun QUATs l\u00ean s\u00e0n, t\u01b0\u1eddng, b\u00e0n c\u00f4ng vi\u1ec7c (n\u1ed3ng \u0111\u1ed9 1:256)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1edd 15 ph\u00fat contact time<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lau b\u1eb1ng kh\u0103n microfiber s\u1ea1ch (kh\u00f4ng r\u1eeda l\u1ea1i v\u00ec mu\u1ed1n duy tr\u00ec b\u1ec1 m\u1eb7t s\u1ea1ch)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L\u1ed6I: Qu\u00ean r\u1eeda s\u1ea1ch d\u01b0 l\u01b0\u1ee3ng c\u00f2n l\u1ea1i b\u1eb1ng WFI<\/span><\/li>\n<\/ol>\n<blockquote><p><span style=\"font-weight: 400;\"><strong>K\u1ebft qu\u1ea3:<\/strong> D\u01b0 l\u01b0\u1ee3ng s\u1ebd t\u00edch l\u0169y h\u00e0ng ng\u00e0y \u2192 Tu\u1ea7n th\u1ee9 2, vi sinh b\u1eaft \u0111\u1ea7u t\u0103ng \u2192 Tu\u1ea7n th\u1ee9 4, vi sinh Gram \u00e2m xu\u1ea5t hi\u1ec7n (kh\u00e1ng QUATs) \u2192 Ph\u1ea3i chuy\u1ec3n sang h\u00f3a ch\u1ea5t di\u1ec7t b\u00e0o t\u1eed\u00a0<\/span><\/p><\/blockquote>\n<p><span style=\"font-weight: 400;\">Gi\u1ea3i ph\u00e1p \u0111\u00fang: R\u1eeda s\u1ea1ch b\u1eb1ng n\u01b0\u1edbc WFI sau ti\u1ebfp x\u00fac 15 ph\u00fat, ho\u1eb7c <a href=\"https:\/\/sepro.vn\/vi\/su-khac-nhau-giua-amoni-bac-4-va-chat-diet-bao-tu\/\"><strong>lu\u00e2n phi\u00ean QUATs (Quaternary Ammonium Compounds) v\u1edbi H2O2\/Sporicide<\/strong><\/a> \u0111\u1ec3 tr\u00e1nh t\u00edch l\u0169y.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Nhung_Han_Che_Va_Sai_Lam_Khi_Su_Dung_%E2%80%94_Biofilm_Khang_Hoa_Chat_Moi_Truong\"><\/span><b>Nh\u1eefng H\u1ea1n Ch\u1ebf V\u00e0 Sai L\u1ea7m Khi S\u1eed D\u1ee5ng \u2014 Biofilm, Kh\u00e1ng H\u00f3a Ch\u1ea5t, M\u00f4i Tr\u01b0\u1eddng<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">H\u1ea7u h\u1ebft c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c g\u1eb7p ph\u1ea3i nh\u1eefng v\u1ea5n \u0111\u1ec1 kh\u00f4ng l\u01b0\u1eddng tr\u01b0\u1edbc \u0111\u01b0\u1ee3c. <strong><a href=\"https:\/\/sepro.vn\/vi\/nhung-sai-lam-pho-bien-ve-quat\/\">QUATs c\u00f3 nh\u1eefng h\u1ea1n ch\u1ebf r\u00f5 r\u00e0ng<\/a> <\/strong>m\u00e0 n\u1ebfu kh\u00f4ng qu\u1ea3n l\u00fd \u0111\u00fang, s\u1ebd g\u00e2y h\u1eadu qu\u1ea3 nghi\u00eam tr\u1ecdng nh\u01b0 sau:<\/span><\/p>\n<h3><b>H\u1ea1n Ch\u1ebf 1: Biofilm \u2014 N\u01a1i Amoni B\u1eadc 4 Th\u1ea5t B\u1ea1i Ho\u00e0n To\u00e0n<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">H\u00e3y t\u01b0\u1edfng t\u01b0\u1ee3ng m\u1ed9t l\u1edbp d\u1ea7u m\u1ecf b\u00e1m tr\u00ean m\u1eb7t n\u01b0\u1edbc \u2014 \u0111\u00f3 c\u01a1 b\u1ea3n l\u00e0 nh\u1eefng g\u00ec biofilm l\u00e0m. Biofilm l\u00e0 nh\u1eefng c\u1ed9ng \u0111\u1ed3ng vi sinh v\u1eadt b\u00e1m d\u00ednh tr\u00ean b\u1ec1 m\u1eb7t (s\u00e0n, t\u01b0\u1eddng, \u1ed1ng n\u01b0\u1edbc) v\u1edbi l\u1edbp ma tr\u1eadn b\u1ea3o v\u1ec7 b\u00ean ngo\u00e0i g\u1ecdi l\u00e0 EPS (Extracellular Polymeric Substance \u2014 ch\u1ea5t \u0111a ph\u1ea7n l\u00e0 carbohydrate v\u00e0 protein).<\/span><\/p>\n<h4><b>Khi b\u1ea1n phun l\u00ean b\u1ec1 m\u1eb7t c\u00f3 biofilm, \u0111i\u1ec1u g\u00ec x\u1ea3y ra?\u00a0<\/b><\/h4>\n<p><span style=\"font-weight: 400;\">H\u00f3a ch\u1ea5t ch\u1ec9 c\u00f3 th\u1ec3 gi\u1ebft \u0111\u01b0\u1ee3c vi khu\u1ea9n n\u1eb1m \u1edf b\u1ec1 m\u1eb7t ngo\u00e0i c\u1ee7a biofilm. L\u1edbp EPS d\u00e0y \u0111\u1eb7c s\u1ebd c\u1ea3n tr\u1edf ho\u1ea1t ch\u1ea5t th\u1ea9m th\u1ea5u v\u00e0o s\u00e2u b\u00ean trong \u2014 k\u1ebft qu\u1ea3 l\u00e0 nh\u1eefng vi sinh b\u00ean trong biofilm s\u1ed1ng s\u00f3t, ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n, v\u00e0 sau m\u1ed9t v\u00e0i ng\u00e0y, biofilm s\u1ebd l\u1ea1i ph\u1ee5c h\u1ed3i.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong>V\u00ed d\u1ee5 th\u1ef1c t\u1ebf:<\/strong> M\u1ed9t nh\u00e0 m\u00e1y s\u1ea3n xu\u1ea5t ch\u1ebf ph\u1ea9m protein ph\u00e1t hi\u1ec7n Salmonella v\u00e0 Listeria t\u1ed3n t\u1ea1i dai d\u1eb3ng d\u01b0\u1edbi biofilm \u1edf \u1ed1ng tho\u00e1t n\u01b0\u1edbc. D\u00f9 h\u1ecd d\u00f9ng QUATs h\u00e0ng ng\u00e0y trong 3 th\u00e1ng, vi sinh v\u1eabn kh\u00f4ng bi\u1ebfn m\u1ea5t.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong>L\u00fd do:<\/strong> Biofilm kh\u00f4ng b\u1ecb lo\u1ea1i b\u1ecf s\u1ea1ch, v\u00e0 ho\u1ea1t ch\u1ea5t s\u1ebd kh\u00f4ng th\u1ea9m th\u1ea5u qua \u0111\u01b0\u1ee3c. Gi\u1ea3i ph\u00e1p cu\u1ed1i c\u00f9ng l\u00e0 l\u00e0m s\u1ea1ch c\u01a1 h\u1ecdc tr\u01b0\u1edbc (d\u00f9ng b\u00e0n ch\u1ea3i, n\u01b0\u1edbc \u00e1p l\u1ef1c cao) \u0111\u1ec3 lo\u1ea1i b\u1ecf biofilm, r\u1ed3i m\u1edbi b\u1eaft \u0111\u1ea7u kh\u1eed khu\u1ea9n. \u0110\u00f3 g\u1ecdi l\u00e0 &#8220;Clean then Disinfect&#8221; \u2014 ti\u00eau chu\u1ea9n GMP.<\/span><\/p>\n<h3><b>H\u1ea1n Ch\u1ebf 2: Kh\u00e1ng H\u00f3a Ch\u1ea5t \u2014 D\u01b0 L\u01b0\u1ee3ng G\u00e2y Ch\u1ecdn L\u1ecdc Gen Kh\u00e1ng<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">\u0110\u00e2y l\u00e0 h\u1ea1n ch\u1ebf nguy hi\u1ec3m nh\u1ea5t m\u00e0 \u00edt ng\u01b0\u1eddi nh\u1eadn ra. Khi b\u1ea1n \u0111\u1ec3 l\u1ea1i d\u01b0 l\u01b0\u1ee3ng tr\u00ean b\u1ec1 m\u1eb7t sau khi v\u1ec7 sinh, m\u1ed9t \u0111i\u1ec1u x\u1ea3y ra: n\u1ed3ng \u0111\u1ed9 t\u1ed3n l\u1ea1i d\u01b0\u1edbi m\u1ee9c ti\u00eau di\u1ec7t ho\u00e0n to\u00e0n (sub-inhibitory concentration) \u2014 n\u00f3 kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 gi\u1ebft vi sinh, nh\u01b0ng \u0111\u1ee7 \u0111\u1ec3 k\u00edch th\u00edch ch\u00fang ph\u00e1t tri\u1ec3n kh\u1ea3 n\u0103ng kh\u00e1ng h\u00f3a ch\u1ea5t.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong>C\u01a1 ch\u1ebf n\u00e0y g\u1ecdi l\u00e0 selective pressure (\u00e1p l\u1ef1c ch\u1ecdn l\u1ecdc)<\/strong>. Vi sinh v\u1eadt c\u00f3 gen qacE (gen m\u00e3 h\u00f3a cho efflux pump \u2014 nh\u1eefng c\u01a1 ch\u1ebf n\u00e0y gi\u00fap lo\u1ea1i b\u1ecf ho\u1ea1t ch\u1ea5t di\u1ec7t khu\u1ea9n t\u1eeb b\u00ean trong t\u1ebf b\u00e0o) s\u1ebd \u0111\u01b0\u1ee3c ch\u1ecdn l\u1ecdc v\u00e0 ph\u00e1t tri\u1ec3n m\u1ea1nh h\u01a1n. Sau 2-3 th\u00e1ng s\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y, vi sinh v\u1eadt kh\u00e1ng h\u00f3a ch\u1ea5t s\u1ebd tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn trong ph\u00f2ng s\u1ea1ch c\u1ee7a b\u1ea1n.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong>V\u00e0 v\u1ea5n \u0111\u1ec1 th\u1eadm t\u1ec7 h\u01a1n l\u00e0 kh\u00e1ng ch\u00e9o (cross-resistance<\/strong>): Vi sinh v\u1eadt kh\u00e1ng h\u00f3a ch\u1ea5t th\u01b0\u1eddng c\u0169ng kh\u00e1ng c\u00e1c nh\u00f3m kh\u00e1ng sinh kh\u00e1c (fluoroquinolones, macrolides), v\u00ec ch\u00fang s\u1eed d\u1ee5ng c\u01a1 ch\u1ebf efflux pump chung. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">N\u1ebfu m\u1ed9t trong nh\u1eefng vi sinh n\u00e0y l\u1ecdt v\u00e0o s\u1ea3n ph\u1ea9m, kh\u00e1ng sinh \u0111i\u1ec1u tr\u1ecb s\u1ebd v\u00f4 hi\u1ec7u \u2014 r\u1ee7i ro nghi\u00eam tr\u1ecdng cho b\u1ec7nh nh\u00e2n cu\u1ed1i c\u00f9ng s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m.<\/span><\/p>\n<h3><b>H\u1ea1n Ch\u1ebf 3: M\u00f4i Tr\u01b0\u1eddng \u2014 N\u01b0\u1edbc C\u1ee9ng &amp; Ch\u1ea5t Anionic L\u00e0m Gi\u1ea3m Ho\u1ea1t T\u00ednh<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng ph\u1ea3i l\u00fac n\u00e0o c\u0169ng ho\u1ea1t \u0111\u1ed9ng nh\u01b0 c\u00e1c ti\u00eau chu\u1ea9n ghi tr\u00ean gi\u1ea5y. <strong>\u0110i\u1ec1u ki\u00ean m\u00f4i tr\u01b0\u1eddng<\/strong> xung quanh c\u00f3 th\u1ec3 ph\u00e1 h\u1ee7y hi\u1ec7u qu\u1ea3 c\u1ee7a n\u00f3 m\u1ed9t c\u00e1ch im l\u1eb7ng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">N\u01b0\u1edbc c\u1ee9ng (ch\u1ee9a calcium Ca\u00b2\u207a v\u00e0 magnesium Mg\u00b2\u207a) s\u1ebd k\u1ebft t\u1ee7a v\u1edbi h\u00f3a ch\u1ea5t (v\u00ec Amoni b\u1eadc 4 mang \u0111i\u1ec7n t\u00edch d\u01b0\u01a1ng), h\u00ecnh th\u00e0nh c\u00e1c h\u1ee3p ch\u1ea5t kh\u00f4ng h\u00f2a tan. <\/span><\/p>\n<p><strong>K\u1ebft qu\u1ea3: n\u1ed3ng \u0111\u1ed9 th\u1ef1c t\u1ebf ch\u1ec9 c\u00f2n 50-70% so v\u1edbi n\u1ed3ng \u0111\u1ed9 mong mu\u1ed1n.\u00a0<\/strong><\/p>\n<p><b>N\u1ebfu b\u1ea1n pha lo\u00e3ng v\u1edbi t\u1ef7 l\u1ec7 <\/b>1<span style=\"font-weight: 400;\">:256 (nh\u01b0 h\u01b0\u1edbng d\u1eabn) b\u1eb1ng n\u01b0\u1edbc c\u1ee9ng, n\u1ed3ng \u0111\u1ed9 th\u1ef1c t\u1ebf c\u00f3 th\u1ec3 ch\u1ec9 b\u1eb1ng 1:400, qu\u00e1 y\u1ebfu \u0111\u1ec3 di\u1ec7t vi sinh hi\u1ec7u qu\u1ea3.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong>Khi s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t Surfactant anionic (t\u1eeb x\u00e0 ph\u00f2ng, d\u1ea7u, n\u01b0\u1edbc r\u1eeda tay)<\/strong> ch\u00fang s\u1ebd c\u1ea1nh tranh v\u1edbi vi sinh v\u1eadt \u0111\u1ec3 b\u00e1m v\u00e0o ho\u1ea1t ch\u1ea5t khi b\u1eaft \u0111\u1ea7u kh\u1eed khu\u1ea9n. Khi c\u1ea1nh tranh, ho\u1ea1t ch\u1ea5t s\u1ebd g\u1eafn v\u00e0o <strong>surfactant<\/strong> thay v\u00ec v\u00e0o vi sinh \u2014 \u0111i\u1ec1u n\u00e0y l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">D\u01b0 l\u01b0\u1ee3ng b\u1ecb oxidation (ti\u1ebfp x\u00fac v\u1edbi oxygen, \u00e1nh s\u00e1ng) s\u1ebd b\u1ecb ph\u00e2n h\u1ee7y, <strong><a href=\"https:\/\/sepro.vn\/vi\/quat-co-de-lai-can-khong\/\">t\u1ea1o ra c\u00e1c c\u1eb7n b\u1ea9n li ti<\/a><\/strong>, d\u1eabn \u0111\u1ebfn t\u00edch t\u1ee5 h\u1ea1t tr\u00ean b\u1ec1 m\u1eb7t \u2014 \u00f4 nhi\u1ec5m mu\u00f4n v\u00e0n l\u1ea7n t\u1ec7 h\u01a1n l\u00e0 vi sinh.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Quaternary_Ammonium_Compounds_QACs_Trong_Chuong_Trinh_Luan_Phien_Hoa_Chat\"><\/span><strong>Quaternary Ammonium Compounds (QACs) Trong Ch\u01b0\u01a1ng Tr\u00ecnh Lu\u00e2n Phi\u00ean H\u00f3a Ch\u1ea5t<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">T\u1edbi \u0111\u00e2y, b\u1ea1n c\u00f3 th\u1ec3 \u0111ang ngh\u0129: <strong>&#8220;N\u1ebfu Quaternary Ammonium Compounds c\u00f3 qu\u00e1 nhi\u1ec1u h\u1ea1n ch\u1ebf, t\u1ea1i sao c\u00f2n d\u00f9ng n\u00f3?&#8221; <\/strong><\/span><\/p>\n<figure id=\"attachment_9722\" aria-describedby=\"caption-attachment-9722\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-9722 size-full\" src=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/3-3.png\" alt=\"luan-phien-quats-kiem-soat-vi-sinh\" width=\"600\" height=\"600\" srcset=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/3-3.png 600w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/3-3-300x300.png 300w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/3-3-150x150.png 150w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/04\/3-3-100x100.png 100w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9722\" class=\"wp-caption-text\"><em>QUATs ki\u1ec3m so\u00e1t vi sinh trong ch\u01b0\u01a1ng tr\u00ecnh lu\u00e2n phi\u00ean<\/em><\/figcaption><\/figure>\n<p><b>C\u00e2u tr\u1ea3 l\u1eddi n\u1eb1m \u1edf c\u00e1ch b\u1ea1n s\u1eed d\u1ee5ng n\u00f3 <\/b><span style=\"font-weight: 400;\">\u2014 kh\u00f4ng ph\u1ea3i d\u00f9ng m\u1ed9t m\u00ecnh, m\u00e0 k\u1ebft h\u1ee3p n\u00f3 v\u1edbi chi\u1ebfn l\u01b0\u1ee3c r\u1ed9ng h\u01a1n.<\/span><\/p>\n<h3><b>T\u1ea1i Sao Kh\u00f4ng D\u00f9ng H\u00e0ng Ng\u00e0y?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">D\u00f9ng h\u00e0ng ng\u00e0y s\u1ebd d\u1eabn \u0111\u1ebfn:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u01b0 l\u01b0\u1ee3ng t\u00edch t\u1ee5 h\u00e0ng ng\u00e0y (kh\u00f4ng k\u1ecbp r\u1eeda s\u1ea1ch)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">N\u1ed3ng \u0111\u1ed9 sub-inhibitory \u2192 K\u00edch th\u00edch qacE gen<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vi sinh kh\u00e1ng h\u00f3a ch\u1ea5t t\u0103ng t\u1eeb tu\u1ea7n 2-3<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hi\u1ec7u qu\u1ea3 QUATs gi\u1ea3m t\u1eeb &gt;4 log xu\u1ed1ng &lt;2 log trong th\u00e1ng th\u1ee9 2-3<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kh\u00e1ng ch\u00e9o v\u1edbi kh\u00e1ng sinh x\u1ea3y ra<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\"><strong>K\u1ebft qu\u1ea3<\/strong>: B\u1ea1n c\u00f3 v\u1ebb nh\u01b0 \u0111ang ki\u1ec3m so\u00e1t vi sinh nh\u00e0 m\u00e1y 1 c\u00e1ch hi\u1ec7u qu\u1ea3, nh\u01b0ng th\u1ef1c ch\u1ea5t nh\u1eefng vi sinh v\u1eadt c\u00f3 \u0111\u1eb7c t\u00ednh kh\u00e1ng h\u00f3a ch\u1ea5t v\u1eabn \u0111ang ph\u00e1t tri\u1ec3n th\u1ea7m l\u1eb7ng. Khi x\u1ea3y ra s\u1ef1 c\u1ed1 nh\u01b0 vi sinh kh\u00e1ng ch\u00e9o, quy tr\u00ecnh kh\u1eed khu\u1ea9n n\u00ean \u00e1p d\u1ee5ng lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t di\u1ec7t b\u00e0o t\u1eed ho\u1eb7c gi\u1eef IPA v\u00e0 QUATs<\/span><\/p>\n<h3><b>Chi\u1ebfn L\u01b0\u1ee3c Lu\u00e2n Phi\u00ean: QUATs+ Sporicide + H2O2 (HYDROGEN PEROXIDE 3%)<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Thay v\u00ec d\u00f9ng h\u00e0ng ng\u00e0y, vi\u1ec7c lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t n\u00ean theo m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c c\u00f3 k\u1ebf ho\u1ea1ch c\u1ee5 th\u1ec3:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><b>Ng\u00e0y<\/b><\/td>\n<td><b>H\u00f3a ch\u1ea5t ch\u00ednh<\/b><\/td>\n<td><b>S\u00e0n<\/b><\/td>\n<td><b>T\u01b0\u1eddng<\/b><\/td>\n<td><b>Tr\u1ea7n<\/b><\/td>\n<td><b>Thi\u1ebft b\u1ecb \/ b\u1ec1 m\u1eb7t l\u00e0m vi\u1ec7c<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Th\u1ee9 2<\/span><\/td>\n<td><b>QUATs<\/b><\/td>\n<td><span style=\"font-weight: 400;\">H\u1eb1ng ng\u00e0y<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Theo l\u1ecbch \/ shutdown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u01b0\u1edbc &amp; sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Th\u1ee9 3<\/span><\/td>\n<td><b>QUATs<\/b><\/td>\n<td><span style=\"font-weight: 400;\">H\u1eb1ng ng\u00e0y<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Theo l\u1ecbch \/ shutdown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u01b0\u1edbc &amp; sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Th\u1ee9 4<\/span><\/td>\n<td><b>H2O2 3%<\/b><\/td>\n<td><span style=\"font-weight: 400;\">H\u1eb1ng ng\u00e0y<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Theo l\u1ecbch \/ shutdown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u01b0\u1edbc &amp; sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Th\u1ee9 5<\/span><\/td>\n<td><b>QUATs<\/b><\/td>\n<td><span style=\"font-weight: 400;\">H\u1eb1ng ng\u00e0y<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Theo l\u1ecbch \/ shutdown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u01b0\u1edbc &amp; sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Th\u1ee9 6<\/span><\/td>\n<td><b>QUATs<\/b><\/td>\n<td><span style=\"font-weight: 400;\">H\u1eb1ng ng\u00e0y<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Theo l\u1ecbch \/ shutdown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u01b0\u1edbc &amp; sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Th\u1ee9 7<\/span><\/td>\n<td><b>H2O2 3%<\/b><\/td>\n<td><span style=\"font-weight: 400;\">H\u1eb1ng ng\u00e0y<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Theo l\u1ecbch \/ shutdown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tr\u01b0\u1edbc &amp; sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ch\u1ee7 nh\u1eadt \/ ng\u00e0y shutdown<\/span><\/td>\n<td><b>Sporicide<\/b><\/td>\n<td><span style=\"font-weight: 400;\">\u00c1p d\u1ee5ng to\u00e0n b\u1ed9<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u00c1p d\u1ee5ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u00c1p d\u1ee5ng n\u1ebfu c\u00f3 l\u1ecbch<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u00c1p d\u1ee5ng to\u00e0n b\u1ed9<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"Cach_dien_dat_ngan_gon_de_dua_vao_SOP\"><\/span><b>C\u00e1ch di\u1ec5n \u0111\u1ea1t ng\u1eafn g\u1ecdn \u0111\u1ec3 \u0111\u01b0a v\u00e0o SOP<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><b>Chi\u1ebfn l\u01b0\u1ee3c lu\u00e2n phi\u00ean 1 tu\u1ea7n:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u00f9ng <strong>Quaternary Ammonium Compounds (QACs)<\/strong> <\/span><span style=\"font-weight: 400;\">l\u00e0m ch\u1ea5t kh\u1eed khu\u1ea9n ch\u00ednh cho v\u1ec7 sinh th\u01b0\u1eddng quy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xen k\u1ebd <\/span><b>H2O2 (HYDROGEN PEROXIDE 3%)<\/b><span style=\"font-weight: 400;\"> v\u00e0o <\/span><b>2 ng\u00e0y\/tu\u1ea7n<\/b><span style=\"font-weight: 400;\"> \u0111\u1ec3 thay \u0111\u1ed5i ho\u1ea1t ch\u1ea5t kh\u1eed khu\u1ea9n.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Th\u1ef1c hi\u1ec7n <\/span><b>Sporicide 1 ng\u00e0y\/tu\u1ea7n<\/b><span style=\"font-weight: 400;\"> v\u00e0o ng\u00e0y v\u1ec7 sinh \u0111\u1ecbnh k\u1ef3 \/ shutdown cho s\u00e0n, t\u01b0\u1eddng, thi\u1ebft b\u1ecb v\u00e0 c\u00e1c b\u1ec1 m\u1eb7t y\u00eau c\u1ea7u.<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Ket_qua_van_hanh_dat_duoc\"><\/span><b>K\u1ebft qu\u1ea3 v\u1eadn h\u00e0nh \u0111\u1ea1t \u0111\u01b0\u1ee3c<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>S\u00e0n<\/b><span style=\"font-weight: 400;\"> \u0111\u01b0\u1ee3c x\u1eed l\u00fd <\/span><b>m\u1ed7i ng\u00e0y<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>T\u01b0\u1eddng<\/b><span style=\"font-weight: 400;\"> \u0111\u01b0\u1ee3c x\u1eed l\u00fd <\/span><b>2\u20133 l\u1ea7n\/tu\u1ea7n<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tr\u1ea7n<\/b><span style=\"font-weight: 400;\"> th\u1ef1c hi\u1ec7n <\/span><b>theo l\u1ecbch ho\u1eb7c khi shutdown<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Thi\u1ebft b\u1ecb \/ b\u1ec1 m\u1eb7t l\u00e0m vi\u1ec7c<\/b><strong> x\u1eed l\u00fd <\/strong><b>tr\u01b0\u1edbc v\u00e0 sau s\u1eed d\u1ee5ng<\/b>.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Tai_Sao_Ket_Hop_La_Giai_Phap_Dung\"><\/span><b>T\u1ea1i Sao K\u1ebft H\u1ee3p L\u00e0 Gi\u1ea3i Ph\u00e1p \u0110\u00fang?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><b>C\u01a1 Ch\u1ebf T\u00e1c \u0110\u1ed9ng Kh\u00e1c Nhau = Kh\u00f3 Kh\u00e1ng Ch\u00e9o<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>Quaternary Ammonium Compounds (QACs)<\/strong>: C\u01a1 ch\u1ebf = Ph\u00e1 v\u1ee1 m\u00e0ng t\u1ebf b\u00e0o (t\u01b0\u01a1ng t\u00e1c t\u0129nh \u0111i\u1ec7n) \u2014 hi\u1ec7u qu\u1ea3 v\u1edbi Bacillus subtilis ATCC 6633, Staphylococcus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong><a href=\"https:\/\/sepro.vn\/vi\/co-che-diet-bao-tu-cua-paa-h2o2-trong-phong-sach-gmp\/\">Sporicide (PAA + H2O2): C\u01a1 ch\u1ebf = Oxy h\u00f3a protein, DNA (g\u1ed1c t\u1ef1 do) hi\u1ec7u qu\u1ea3 v\u1edbi b\u00e0o t\u1eed, biofilm<\/a><\/strong><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>H2O2 (HYDROGEN PEROXIDE 3%)<\/strong>: C\u01a1 ch\u1ebf = Ph\u00e2n h\u1ee7y t\u1ebf b\u00e0o th\u00f4ng qua g\u1ed1c hydroxyl \u2014 hi\u1ec7u qu\u1ea3 v\u1edbi Gram \u00e2m, Adenovirus type 5 ATCC VR-5<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Vi sinh v\u1eadt kh\u00f3 c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n kh\u00e1ng c\u00f9ng l\u00fac 3 c\u01a1 ch\u1ebf kh\u00e1c nhau. N\u1ebfu n\u00f3 kh\u00e1ng \u0111\u01b0\u1ee3c <b>Amoni b\u1eadc 4 <\/b>(efflux pump), n\u00f3 v\u1eabn s\u1ebd b\u1ecb oxy h\u00f3a b\u1edfi PAA.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">K\u1ebft qu\u1ea3: t\u1ef7 l\u1ec7 kh\u00e1ng ch\u00e9o <\/span><b>gi\u1ea3m t\u1eeb 30-50%<\/b><span style=\"font-weight: 400;\"> (Quaternary Ammonium Compounds \u0111\u01a1n l\u1ebb) xu\u1ed1ng <\/span><b>d\u01b0\u1edbi 5%<\/b><span style=\"font-weight: 400;\"> (k\u1ebft h\u1ee3p).<\/span><\/p>\n<h3><b>An To\u00e0n Cho Nh\u00e2n Vi\u00ean K\u1ef9 Thu\u1eadt<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><strong>D\u00f9ng<\/strong><span style=\"font-weight: 400;\"><strong> h\u00e0ng ng\u00e0y:<\/strong> Ti\u1ebfp x\u00fac &gt;250 ng\u00e0y\/n\u0103m \u2192 R\u1ee7i ro d\u1ecb \u1ee9ng, t\u00edch l\u0169y \u0111\u1ed9c t\u00ednh \u2192 C\u1ea7n \u0111i\u1ec1u tra y t\u1ebf<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><strong>D\u00f9ng lu\u00e2n phi\u00ean:<\/strong> Ti\u1ebfp x\u00fac ch\u1ec9 50-70 ng\u00e0y\/n\u0103m \u2192 R\u1ee7i ro gi\u1ea3m m\u1ea1nh \u2192 An to\u00e0n h\u01a1n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Th\u00eam v\u00e0o \u0111\u00f3, r\u1eeda s\u1ea1ch l\u01b0\u1ee3ng h\u00f3a ch\u1ea5t d\u01b0 th\u1eeba c\u00f2n l\u1ea1i b\u1eb1ng WFI + Lu\u00e2n phi\u00ean \u0111\u1ea3m b\u1ea3o d\u01b0 l\u01b0\u1ee3ng kh\u00f4ng t\u00edch t\u1ee5 \u2192 Kh\u00f4ng k\u00edch th\u00edch kh\u00e1ng \u2192 Vi sinh kh\u00f4ng ph\u00e1t tri\u1ec3n kh\u00e1ng ch\u00e9o.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"FAQs_%E2%80%93_Quaternary_Ammonium_Compounds_QACs\"><\/span><strong>FAQs &#8211; Quaternary Ammonium Compounds (QACs)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<blockquote>\n<h3><strong>Quaternary Ammonium Compounds (QACs) c\u00f3 ph\u00f9 h\u1ee3p cho ki\u1ec3m so\u00e1t vi sinh ph\u00f2ng s\u1ea1ch kh\u00f4ng?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00f3, nh\u01b0ng ch\u1ec9 cho Grade C\/D v\u00e0 maintenance. \u0110\u1eebng d\u00f9ng n\u00f3 l\u00e0m l\u1ef1a ch\u1ecdn ch\u00ednh cho Grade A (v\u00f9ng s\u1ea3n xu\u1ea5t tr\u1ef1c ti\u1ebfp). N\u1ebfu d\u00f9ng \u0111\u00fang c\u00e1ch (r\u1eeda s\u1ea1ch, lu\u00e2n phi\u00ean), <strong>QUATs r\u1ea5t hi\u1ec7u qu\u1ea3 v\u00e0 ti\u1ebft ki\u1ec7m.<\/strong><\/span><\/p>\n<h3><b>C\u00f3 th\u1ec3 d\u00f9ng h\u00e0ng ng\u00e0y kh\u00f4ng?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng n\u00ean. D\u00f9ng h\u00e0ng ng\u00e0y d\u1eabn \u0111\u1ebfn d\u01b0 l\u01b0\u1ee3ng t\u00edch t\u1ee5, k\u00edch th\u00edch kh\u00e1ng h\u00f3a ch\u1ea5t, v\u00e0 tu\u1ea7n th\u1ee9 3-4 s\u1ebd th\u1ea5y vi sinh t\u0103ng. Lu\u00e2n phi\u00ean gi\u1eefa QUATs 1-2 l\u1ea7n\/tu\u1ea7n v\u1edbi Sporicide\/H2O2 l\u00e0 c\u00e1ch an to\u00e0n h\u01a1n.<\/span><\/p>\n<h3><b>C\u00f3 an to\u00e0n cho da v\u00e0 h\u00f4 h\u1ea5p kh\u00f4ng?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">An to\u00e0n n\u1ebfu d\u00f9ng n\u1ed3ng \u0111\u1ed9 khuy\u1ebfn c\u00e1o (0.5-1%) v\u00e0 tu\u00e2n th\u1ee7 PPE (g\u0103ng tay, kh\u1ea9u trang). Tuy nhi\u00ean, ti\u1ebfp x\u00fac h\u00e0ng ng\u00e0y d\u00e0i h\u1ea1n (&gt;250 ng\u00e0y\/n\u0103m) c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng da. Lu\u00e2n phi\u00ean QUATs gi\u1ea3m ti\u1ebfp x\u00fac xu\u1ed1ng 50-70 ng\u00e0y\/n\u0103m, an to\u00e0n h\u01a1n.<\/span><\/p>\n<h3><b>N\u1ebfu \u0111\u1ec3 l\u1ea1i d\u01b0 l\u01b0\u1ee3ng, li\u1ec7u c\u00f3 g\u00e2y \u1ea3nh h\u01b0\u1edfng l\u00e2u d\u00e0i kh\u00f4ng?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00f3. D\u01b0 l\u01b0\u1ee3ng sub-inhibitory k\u00edch th\u00edch vi sinh kh\u00e1ng h\u00f3a ch\u1ea5t, v\u00e0 kh\u00e1ng ch\u00e9o v\u1edbi kh\u00e1ng sinh. R\u1eeda s\u1ea1ch b\u1eb1ng WFI ngay sau ti\u1ebfp x\u00fac (15-20 ph\u00fat) l\u00e0 c\u00e1ch tr\u00e1nh.<\/span><\/p>\n<h3><b>D\u00f9ng \u0111\u1ec3 l\u00e0m g\u00ec trong ph\u00f2ng s\u1ea1ch?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">\u0110\u1ec3 ki\u1ec3m so\u00e1t vi sinh h\u00e0ng ng\u00e0y \u1edf <strong>Grade C\/D<\/strong> (h\u00e0nh lang, kho, khu ph\u1ee5 tr\u1ee3), l\u00e0m s\u1ea1ch s\u00e0n, t\u01b0\u1eddng, b\u00e0n c\u00f4ng vi\u1ec7c, thi\u1ebft b\u1ecb kh\u00f4ng ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp.<strong> Hi\u1ec7u qu\u1ea3 tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng nh\u01b0 Staphylococcus, Bacillus subtilis ATCC 6633, n\u1ea5m Candida albicans ATCC 10231<\/strong>, v\u00e0 l\u00e0 ph\u1ea7n c\u1ee7a chi\u1ebfn l\u01b0\u1ee3c lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t c\u00f9ng Sporicide v\u00e0 H2O2. Tuy nhi\u00ean, <strong>kh\u00f4ng hi\u1ec7u qu\u1ea3 v\u1edbi virus kh\u00f4ng c\u00f3 v\u1ecf lipid nh\u01b0 Adenovirus type 5 ATCC VR-5 hay b\u00e0o t\u1eed Bacillus.<\/strong><\/span><\/p><\/blockquote>\n<h2><span class=\"ez-toc-section\" id=\"Tam_Ket\"><\/span>T\u1ea1m K\u1ebft<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Quaternary Ammonium Compounds (QACs) kh\u00f4ng ph\u1ea3i &#8220;\u0111\u1ed9c d\u01b0\u1ee3c&#8221; nh\u01b0ng c\u0169ng kh\u00f4ng ph\u1ea3i &#8220;gi\u1ea3i ph\u00e1p v\u00e0ng&#8221; \u2014 m\u00e0 l\u00e0 l\u1ef1a ch\u1ecdn ti\u1ebft ki\u1ec7m + hi\u1ec7u qu\u1ea3 n\u1ebfu d\u00f9ng \u0111\u00fang l\u00fac, \u0111\u00fang n\u01a1i, \u0111\u00fang c\u00e1ch, v\u00e0 lu\u00f4n k\u1ebft h\u1ee3p v\u1edbi chi\u1ebfn l\u01b0\u1ee3c r\u1ed9ng h\u01a1n.<\/span><\/p>\n<p><strong><a href=\"https:\/\/sepro.hoachatkhukhuan.vn\/quantumtec\" target=\"_blank\" rel=\"noopener\">SEPRO cung c\u1ea5p b\u1ed9 gi\u1ea3i ph\u00e1p to\u00e0n di\u1ec7n:\u00a0<\/a><\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">QT QUAT cho vi\u1ec7c v\u1ec7 sinh h\u00e0ng ng\u00e0y (Grade C\/D)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">QT SPORICIDE cho s\u1ef1 c\u1ed1 (Grade A)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">QT PEROXY 6% cho Gram \u00e2m k\u00e8m theo gi\u00e1m s\u00e1t li\u00ean t\u1ee5c<\/span><\/li>\n<\/ul>\n<p><b>An to\u00e0n, hi\u1ec7u qu\u1ea3, ti\u1ebft ki\u1ec7m chi ph\u00ed<\/b><span style=\"font-weight: 400;\">. \u0110\u00e2y l\u00e0 c\u00e1ch m\u00e0 c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c h\u00e0ng \u0111\u1ea7u \u1edf Ch\u00e2u \u00c2u v\u00e0 Hoa K\u1ef3 \u0111ang ki\u1ec3m so\u00e1t vi sinh.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trong th\u1ef1c t\u1ebf v\u1eadn h\u00e0nh t\u1ea1i c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c, \u0111\u00e3 ghi nh\u1eadn hi\u1ec7n t\u01b0\u1ee3ng gia t\u0103ng vi sinh sau m\u1ed9t th\u1eddi gian s\u1eed d\u1ee5ng QUATs \u0111\u1ec3 ki\u1ec3m so\u00e1t vi sinh li\u00ean t\u1ee5c. Nguy\u00ean nh\u00e2n th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn chi\u1ebfn l\u01b0\u1ee3c lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t trong ch\u01b0\u01a1ng tr\u00ecnh kh\u1eed khu\u1ea9n. \u0110\u00e1nh gi\u00e1 th\u1ef1c t\u1ebf cho &hellip; <a href=\"https:\/\/sepro.vn\/vi\/quaternary-ammonium-compounds-quats-phong-sach\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Quaternary Ammonium Compounds (QUATs) Ki\u1ec3m So\u00e1t Vi Sinh: Gi\u1ea3i Ph\u00e1p Lu\u00e2n Phi\u00ean B\u1ec1n V\u1eefng C\u00f9ng SEPRO<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":9726,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextinma_seo_power":"","_daextinma_enable_ail":"","footnotes":""},"categories":[126],"tags":[],"class_list":["post-9714","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"_links":{"self":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts\/9714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/comments?post=9714"}],"version-history":[{"count":48,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts\/9714\/revisions"}],"predecessor-version":[{"id":13781,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts\/9714\/revisions\/13781"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/media\/9726"}],"wp:attachment":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/media?parent=9714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/categories?post=9714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/tags?post=9714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}