{"id":9714,"date":"2026-04-14T10:30:24","date_gmt":"2026-04-14T10:30:24","guid":{"rendered":"https:\/\/sepro.vn\/?p=9714"},"modified":"2026-04-14T10:30:24","modified_gmt":"2026-04-14T10:30:24","slug":"quat-kiem-soat-vi-sinh-phong-sach","status":"publish","type":"post","link":"https:\/\/sepro.vn\/vi\/quat-kiem-soat-vi-sinh-phong-sach\/","title":{"rendered":"Quat Ki\u1ec3m So\u00e1t Vi Sinh Ph\u00f2ng S\u1ea1ch \u2014 H\u01b0\u1edbng D\u1eabn Th\u1ef1c T\u1ebf Cho Nh\u00e0 M\u00e1y D\u01b0\u1ee3c"},"content":{"rendered":"

Trong th\u1ef1c t\u1ebf v\u1eadn h\u00e0nh t\u1ea1i c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c, \u0111\u00e3 ghi nh\u1eadn hi\u1ec7n t\u01b0\u1ee3ng gia t\u0103ng vi sinh sau m\u1ed9t th\u1eddi gian s\u1eed d\u1ee5ng QUAT li\u00ean t\u1ee5c. Nguy\u00ean nh\u00e2n th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn chi\u1ebfn l\u01b0\u1ee3c lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t trong ch\u01b0\u01a1ng tr\u00ecnh kh\u1eed khu\u1ea9n.<\/span><\/p>\n

\u0110\u00e1nh gi\u00e1 th\u1ef1c t\u1ebf cho th\u1ea5y d\u01b0 l\u01b0\u1ee3ng QUAT t\u00edch t\u1ee5 tr\u00ean b\u1ec1 m\u1eb7t c\u00f3 th\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi sinh v\u1eadt th\u00edch nghi, d\u1eabn \u0111\u1ebfn gi\u1ea3m hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t theo th\u1eddi gian. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n kh\u00f4ng ch\u1ec9 ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i h\u00f3a ch\u1ea5t m\u00e0 c\u00f2n ph\u1ee5 thu\u1ed9c v\u00e0o c\u00e1ch s\u1eed d\u1ee5ng v\u00e0 chi\u1ebfn l\u01b0\u1ee3c ki\u1ec3m so\u00e1t.<\/span><\/p>\n

Th\u00f4ng qua b\u00e0i vi\u1ebft n\u00e0y, SEPRO<\/strong><\/a> s\u1ebd\u00a0tr\u00ecnh b\u00e0y c\u00e1c sai s\u00f3t th\u01b0\u1eddng g\u1eb7p v\u00e0 nguy\u00ean t\u1eafc s\u1eed d\u1ee5ng QUAT nh\u1eb1m \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3, an to\u00e0n v\u00e0 t\u00ednh b\u1ec1n v\u1eefng trong ki\u1ec3m so\u00e1t vi sinh.<\/span><\/p>\n

Xem th\u00eam t\u1ea1i <\/span><\/i>H\u00d3A CH\u1ea4T KH\u1eec KHU\u1ea8N PH\u00d2NG S\u1ea0CH THEO GMP – EU<\/i><\/a><\/strong> \u0111\u1ec3 t\u00ecm hi\u1ec3u c\u00e1ch ch\u1ecdn h\u00f3a ch\u1ea5t theo Grade ph\u00f2ng s\u1ea1ch.<\/span><\/i><\/p>\n

Quat (Amoni B\u1eadc B\u1ed1n) L\u00e0 G\u00ec V\u00e0 T\u1ea1i Sao N\u00f3 Ph\u1ed5 Bi\u1ebfn Trong Ph\u00f2ng S\u1ea1ch<\/b><\/h2>\n
\"quat-la-gi\"
Quat L\u00e0 G\u00ec ?<\/em><\/figcaption><\/figure>\n

Khi n\u00f3i \u0111\u1ebfn Quat ki\u1ec3m so\u00e1t vi sinh ph\u00f2ng s\u1ea1ch, Quaternary Ammonium Compounds (QACs), hay h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n l\u00e0 lo\u1ea1i h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n m\u1ea1nh m\u1ebd c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t vi khu\u1ea9n, virus v\u00e0 n\u1ea5m m\u00e0 c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c th\u01b0\u1eddng xuy\u00ean s\u1eed d\u1ee5ng trong ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh h\u00e0ng ng\u00e0y.\u00a0<\/span><\/p>\n

Nh\u01b0ng th\u1ef1c s\u1ef1 Quat l\u00e0 g\u00ec?<\/b><\/h3>\n

L\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n (amoni b\u1eadc b\u1ed1n)<\/strong><\/a>, \u0111\u01b0\u1ee3c c\u1ea5u t\u1ea1o t\u1eeb m\u1ed9t nguy\u00ean t\u1eed nit\u01a1 \u0111\u01b0\u1ee3c li\u00ean k\u1ebft v\u1edbi 4 nh\u00f3m alkyl. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a Quat r\u1ea5t \u0111\u01a1n gi\u1ea3n: n\u00f3 mang \u0111i\u1ec7n t\u00edch d\u01b0\u01a1ng (+) b\u1ecb h\u00fat v\u00e0o m\u00e0ng t\u1ebf b\u00e0o vi khu\u1ea9n mang \u0111i\u1ec7n t\u00edch \u00e2m (\u2212), x\u00e2m nh\u1eadp v\u00e0o l\u1edbp lipid bilayer, ph\u00e1 v\u1ee1 c\u1ea5u tr\u00fac v\u00e0 g\u00e2y r\u00f2 r\u1ec9 n\u1ed9i b\u00e0o.\u00a0<\/span><\/p>\n

Phi\u00ean b\u1ea3n m\u1edbi nh\u1ea5t l\u00e0 Quat th\u1ebf h\u1ec7 th\u1ee9 5, \u0111\u01b0\u1ee3c c\u1ea3i ti\u1ebfn \u0111\u1ec3 kh\u00f4ng g\u00e2y \u0103n m\u00f2n, pH trung t\u00ednh, v\u00e0 d\u1ec5 r\u1eeda s\u1ea1ch kh\u1ecfi b\u1ec1 m\u1eb7t.<\/span><\/p>\n

T\u1ea1i sao Quat l\u1ea1i ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf kh\u1eed khu\u1ea9n ph\u00f2ng s\u1ea1ch?\u00a0<\/b><\/h3>\n

Khi so s\u00e1nh gi\u1eefa nhi\u1ec1u lo\u1ea1i h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n, QUAT \u0111\u01b0\u1ee3c \u01b0u ti\u00ean l\u1ef1a ch\u1ecdn nh\u1edd chi ph\u00ed th\u1ea5p, \u00e1p d\u1ee5ng \u0111\u01b0\u1ee3c cho c\u1ea3 v\u1ec7 sinh v\u00e0 kh\u1eed khu\u1ea9n h\u1eb1ng ng\u00e0y, m\u1ee9c \u0111\u1ed9 \u0103n m\u00f2n th\u1ea5p v\u00e0 \u0111\u1ed9 an to\u00e0n t\u01b0\u01a1ng \u0111\u1ed1i \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi s\u1eed d\u1ee5ng, t\u00f9y thu\u1ed9c v\u00e0o n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111i\u1ec1u ki\u1ec7n \u00e1p d\u1ee5ng.<\/span><\/p>\n

Do \u0111\u00f3, QUAT th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n ch\u00ednh trong ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh \u0111\u1ecbnh k\u1ef3 t\u1ea1i c\u00e1c khu v\u1ef1c Grade C v\u00e0 D trong nh\u00e0 m\u00e1y d\u01b0\u1ee3c.<\/span><\/p>\n

So s\u00e1nh nhanh: Quat vs Alcohol vs H2O2<\/b><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Ti\u00eau Ch\u00ed<\/b><\/td>\nQuat<\/b><\/td>\nAlcohol (IPA\/Ethanol)<\/b><\/td>\nH2O2 6%<\/b><\/td>\n<\/tr>\n
Contact Time<\/span><\/td>\n10-15 ph\u00fat<\/span><\/td>\n2-10 ph\u00fat<\/span><\/td>\n20-30 ph\u00fat<\/span><\/td>\n<\/tr>\n
Gram D\u01b0\u01a1ng<\/span><\/td>\nCao (>4 log)<\/span><\/td>\nCao (>4 log)<\/span><\/td>\nCao (>4 log)<\/span><\/td>\n<\/tr>\n
Gram \u00c2m<\/span><\/td>\nTh\u1ea5p (30-50%)<\/span><\/td>\nTh\u1ea5p (30-50%)<\/span><\/td>\nCao (>4 log)<\/span><\/td>\n<\/tr>\n
N\u1ea5m<\/span><\/td>\nTrung b\u00ecnh<\/span><\/td>\nTh\u1ea5p<\/span><\/td>\nCao<\/span><\/td>\n<\/tr>\n
Virus C\u00f3 V\u1ecf Lipid<\/span><\/td>\nCao<\/span><\/td>\nCao<\/span><\/td>\nTrung b\u00ecnh<\/span><\/td>\n<\/tr>\n
Virus Kh\u00f4ng V\u1ecf<\/span><\/td>\nTh\u1ea5p<\/span><\/td>\nTh\u1ea5p<\/span><\/td>\nCao<\/span><\/td>\n<\/tr>\n
B\u00e0o T\u1eed<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\n<\/tr>\n
D\u01b0 L\u01b0\u1ee3ng<\/span><\/td>\nC\u00f3 (c\u1ea7n r\u1eeda WFI)<\/span><\/td>\nKh\u00f4ng (bay h\u01a1i)<\/span><\/td>\nKh\u00f4ng (ph\u00e2n h\u1ee7y)<\/span><\/td>\n<\/tr>\n
Chi Ph\u00ed<\/span><\/td>\nR\u1ebb<\/span><\/td>\nR\u1ebb-Trung b\u00ecnh<\/span><\/td>\nTrung b\u00ecnh-\u0110\u1eaft<\/span><\/td>\n<\/tr>\n
\u0102n M\u00f2n V\u1eadt Li\u1ec7u<\/span><\/td>\nKh\u00f4ng (pH trung t\u00ednh)<\/span><\/td>\nC\u00f3 (ethanol)<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\n<\/tr>\n
Ph\u00f9 H\u1ee3p<\/span><\/td>\nGrade C\/D<\/span><\/td>\nGrade B\/C<\/span><\/td>\nGrade A\/B<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Xem th\u00eam t\u1ea1i <\/span><\/i>DUNG D\u1ecaCH QT QUAT<\/i><\/a><\/strong> \u0111\u1ec3 t\u00ecm hi\u1ec3u v\u1ec1 Quat th\u1ebf h\u1ec7 th\u1ee9 5 pH trung t\u00ednh.<\/span><\/i><\/p>\n

Quat Ki\u1ec3m So\u00e1t Vi Sinh N\u00e0o Hi\u1ec7u Qu\u1ea3 V\u00e0 Kh\u00f4ng Hi\u1ec7u Qu\u1ea3<\/b><\/h2>\n

Khi b\u1eaft \u0111\u1ea7u ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m so\u00e1t vi sinh, m\u1ed9t nh\u00e2n vi\u00ean QA\/QC th\u01b0\u1eddng h\u1ecfi: “Quat c\u00f3 th\u1ef1c s\u1ef1 di\u1ec7t \u0111\u01b0\u1ee3c t\u1ea5t c\u1ea3 vi sinh kh\u00f4ng?” C\u00e2u tr\u1ea3 l\u1eddi kh\u00f4ng mang t\u00ednh tuy\u1ec7t \u0111\u1ed1i, m\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a c\u00e1c ch\u1ee7ng vi sinh c\u00f3 trong m\u00f4i tr\u01b0\u1eddng ph\u00f2ng s\u1ea1ch.<\/span><\/p>\n

Quat hi\u1ec7u qu\u1ea3 v\u1edbi lo\u1ea1i vi sinh n\u00e0o?<\/b><\/h3>\n

QUAT c\u00f3 hi\u1ec7u qu\u1ea3 cao tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i t\u1ef1 do (planktonic), th\u01b0\u1eddng \u0111\u1ea1t \u22654 log reduction (\u226599,99%), bao g\u1ed3m c\u00e1c ch\u1ee7ng nh\u01b0 Staphylococcus aureus v\u00e0 Bacillus subtilis ATCC 6633. Th\u1eddi gian ti\u1ebfp x\u00fac ch\u1ec9 c\u1ea7n 10-15 ph\u00fat v\u1edbi n\u1ed3ng \u0111\u1ed9 0.5-1%.<\/span><\/p>\n

N\u00f3 c\u0169ng di\u1ec7t \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 n\u1ea5m nh\u01b0 Candida albicans ATCC 10231 (y\u00eau c\u1ea7u 15-20 ph\u00fat), v\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i hi\u1ec7u qu\u1ea3 v\u1edbi virus c\u00f3 v\u1ecf lipid nh\u01b0 coronavirus, influenza (2-10 ph\u00fat).<\/span><\/p>\n

Quat k\u00e9m hi\u1ec7u qu\u1ea3 v\u1edbi g\u00ec?<\/b><\/h3>\n

Hi\u1ec7u qu\u1ea3 c\u1ee7a QUAT gi\u1ea3m \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi vi khu\u1ea9n Gram \u00e2m (v\u00ed d\u1ee5 Pseudomonas, E. coli) so v\u1edbi vi khu\u1ea9n Gram d\u01b0\u01a1ng ch\u1ec9 c\u00f2n 30-50% kh\u1eed khu\u1ea9n. L\u00fd do l\u00e0 m\u00e0ng ngo\u00e0i c\u1ee7a Gram \u00e2m ch\u1ee9a lipopolysaccharide (LPS) l\u00e0m h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng th\u1ea5m c\u1ee7a Amoniac B\u1eadc 4.<\/span><\/p>\n

V\u1edbi biofilm (nh\u1eefng c\u1ed9ng \u0111\u1ed3ng vi sinh b\u00e1m d\u00ednh tr\u00ean b\u1ec1 m\u1eb7t c\u00f3 l\u1edbp ma tr\u1eadn b\u1ea3o v\u1ec7), l\u00e0m h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn c\u1ee7a h\u00f3a ch\u1ea5t. Quat g\u1ea7n nh\u01b0 kh\u00f4ng c\u00f2n \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3<\/span><\/p>\n

Virus kh\u00f4ng c\u00f3 v\u1ecf lipid nh\u01b0 Adenovirus type 5 ATCC VR-5, hepatitis A, norovirus c\u0169ng kh\u00e1ng Quat. V\u00e0 b\u00e0o t\u1eed vi khu\u1ea9n (Clostridium difficile, Bacillus subtilis ATCC 6633 \u1edf d\u1ea1ng b\u00e0o t\u1eed) ho\u00e0n to\u00e0n kh\u00f4ng b\u1ecb di\u1ec7t b\u1edfi Quat \u2014 ch\u00fang c\u1ea7n h\u00f3a ch\u1ea5t di\u1ec7t b\u00e0o t\u1eed nh\u01b0 H2O2 hay PAA ho\u1eb7c h\u00f3a ch\u1ea5t k\u1ebft h\u1ee3p c\u1ea3 2 ho\u1ea1t ch\u1ea5t.<\/span><\/p>\n

B\u1ea3ng Ki\u1ec3m So\u00e1t Vi Sinh V\u1edbi Quat:<\/b><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n
Y\u1ebfu T\u1ed1<\/b><\/td>\nHi\u1ec7u Qu\u1ea3<\/b><\/td>\nL\u01b0u \u00dd<\/b><\/td>\n<\/tr>\n
Planktonic Gram+ (Staph, Bacillus subtilis ATCC 6633 t\u1ef1 do)<\/span><\/td>\nCao (>4 log)<\/span><\/td>\nContact time 10-15 ph\u00fat, n\u1ed3ng \u0111\u1ed9 0.5-1%<\/span><\/td>\n<\/tr>\n
Biofilm Gram- (Pseudomonas b\u00e1m d\u00ednh)<\/span><\/td>\nTh\u1ea5p (<2 log)<\/span><\/td>\nC\u1ea7n k\u1ebft h\u1ee3p PAA ho\u1eb7c l\u00e0m s\u1ea1ch c\u01a1 h\u1ecdc tr\u01b0\u1edbc<\/span><\/td>\n<\/tr>\n
N\u1ea5m (Candida albicans ATCC 10231)<\/span><\/td>\nTrung b\u00ecnh (2-3 log)<\/span><\/td>\nContact time 15-20 ph\u00fat, nh\u1ea1y c\u1ea3m v\u1edbi Quat<\/span><\/td>\n<\/tr>\n
Virus C\u00f3 V\u1ecf Lipid<\/span><\/td>\nCao (>3 log)<\/span><\/td>\nDi\u1ec7t nhanh trong 2-10 ph\u00fat<\/span><\/td>\n<\/tr>\n
Virus Kh\u00f4ng V\u1ecf (Adenovirus type 5 ATCC VR-5)<\/span><\/td>\nTh\u1ea5p (<1 log)<\/span><\/td>\nKh\u00e1ng Quat, c\u1ea7n H2O2 ho\u1eb7c PAA<\/span><\/td>\n<\/tr>\n
B\u00e0o T\u1eed (Bacillus subtilis ATCC 6633 spore)<\/span><\/td>\nKh\u00f4ng (0 log)<\/span><\/td>\nHo\u00e0n to\u00e0n kh\u00e1ng, c\u1ea7n Sporicide<\/span><\/td>\n<\/tr>\n
D\u01b0 l\u01b0\u1ee3ng QUAT<\/span><\/td>\nC\u00f3 (>2 \u00b5g\/cm\u00b2)<\/span><\/td>\nTr\u00e1nh d\u01b0\u1edbi MIC k\u00edch th\u00edch kh\u00e1ng h\u00f3a ch\u1ea5t<\/span><\/td>\n<\/tr>\n
N\u01b0\u1edbc c\u1ee9ng<\/span><\/td>\nGi\u1ea3m 30-50%<\/span><\/td>\nD\u00f9ng WFI thay n\u01b0\u1edbc m\u00e1y<\/span><\/td>\n<\/tr>\n
Monitoring<\/span><\/td>\nSettle plate<\/span><\/td>\n<1 CFU\/plate theo GMP Vi\u1ec7t Nam ti\u00eau chu\u1ea9n<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Xem th\u00eam t\u1ea1i <\/span><\/i>\u00d4 NHI\u1ec4M PH\u00d2NG S\u1ea0CH L\u00c0 G\u00cc: 6 NGU\u1ed2N B\u1ea2N HAY B\u1eca B\u1ece S\u00d3T<\/span><\/i><\/a> \u0111\u1ec3 nh\u1eadn di\u1ec7n nh\u1eefng \u0111i\u1ec3m khu\u1ea5t d\u1ec5 t\u00edch vi sinh m\u00e0 Quat kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c.<\/span><\/i><\/p>\n

Khi N\u00e0o N\u00ean D\u00f9ng Quat Trong Ch\u01b0\u01a1ng Tr\u00ecnh Ki\u1ec3m So\u00e1t Vi Sinh<\/b><\/h2>\n

Trong v\u1eadn h\u00e0nh ph\u00f2ng s\u1ea1ch GMP, m\u1ed9t sai s\u00f3t th\u01b0\u1eddng g\u1eb7p l\u00e0 \u00e1p d\u1ee5ng c\u00f9ng m\u1ed9t h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n cho to\u00e0n b\u1ed9 c\u00e1c khu v\u1ef1c m\u00e0 kh\u00f4ng ph\u00e2n bi\u1ec7t m\u1ee9c \u0111\u1ed9 y\u00eau c\u1ea7u ki\u1ec3m so\u00e1t. QUAT ph\u00f9 h\u1ee3p cho c\u00e1c khu v\u1ef1c Grade C v\u00e0 D, bao g\u1ed3m khu ph\u1ee5 tr\u1ee3 v\u00e0 h\u00e0nh lang kho, n\u01a1i kh\u00f4ng ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi s\u1ea3n ph\u1ea9m v\u00e0 c\u00f3 y\u00eau c\u1ea7u ki\u1ec3m so\u00e1t vi sinh \u1edf m\u1ee9c th\u1ea5p h\u01a1n.<\/span><\/p>\n

Quat cho khu v\u1ef1c n\u00e0o?<\/b><\/h3>\n

Quat l\u00e0 l\u1ef1a ch\u1ecdn t\u1ed1i \u01b0u cho ki\u1ec3m so\u00e1t vi sinh h\u00e0ng ng\u00e0y Grade C, D v\u00e0 c\u00e1c khu v\u1ef1c h\u1ed7 tr\u1ee3, h\u00e0nh lang, kho, ph\u00f2ng nguy\u00ean li\u1ec7u. Amoni b\u1eadc 4 c\u0169ng \u0111\u01b0\u1ee3c d\u00f9ng trong ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh & kh\u1eed khu\u1ea9n h\u1eb1ng ng\u00e0y cho c\u00e1c khu v\u1ef1c ph\u00f2ng s\u1ea1ch khi kh\u00f4ng c\u00f3 s\u1ef1 c\u1ed1.\u00a0<\/span><\/p>\n

Tuy nhi\u00ean n\u1ebfu mu\u1ed1n s\u1eed d\u1ee5ng \u1edf Grade A (v\u00f9ng s\u1ea3n xu\u1ea5t tr\u1ef1c ti\u1ebfp) th\u00ec ph\u1ea3i k\u1ebft h\u1ee3p s\u1eed d\u1ee5ng th\u00eam h\u00f3a ch\u1ea5t di\u1ec7t \u0111\u01b0\u1ee3c b\u00e0o t\u1eed v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ec7t tr\u00f9ng.<\/span><\/p>\n

Quat cho b\u1ec1 m\u1eb7t n\u00e0o?<\/b><\/h3>\n

S\u00e0n, t\u01b0\u1eddng, b\u00e0n, thau r\u1eeda, d\u1ee5ng c\u1ee5 kh\u00f4ng ti\u1ebfp x\u00fac th\u1ef1c ph\u1ea9m \u2014 nh\u1eefng b\u1ec1 m\u1eb7t n\u00e0y \u0111\u01b0\u1ee3c v\u1ec7 sinh h\u00e0ng ng\u00e0y b\u1eb1ng Quat. Thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t (mixer, m\u00e1y filling) c\u0169ng c\u00f3 th\u1ec3 d\u00f9ng Quat n\u1ebfu kh\u00f4ng li\u00ean quan tr\u1ef1c ti\u1ebfp \u0111\u1ebfn s\u1ea3n ph\u1ea9m.\u00a0<\/span><\/p>\n

Nh\u01b0ng n\u1ebfu vi sinh t\u0103ng b\u1ea5t th\u01b0\u1eddng, \u0111\u1eb7c bi\u1ec7t l\u00e0 b\u00e0o t\u1eed \u1edf m\u1ed9t khu v\u1ef1c c\u1ee5 th\u1ec3, <\/span>b\u1ea1n c\u1ea7n chuy\u1ec3n sang h\u00f3a ch\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n m\u1ea1nh h\u01a1n nh\u01b0 Sporicide.<\/b><\/p>\n

V\u00ed d\u1ee5 th\u1ef1c t\u1ebf: S\u1eed d\u1ee5ng Quat trong QC\/QA daily checklist<\/b><\/h3>\n

Ng\u00e0y h\u00f4m nay, b\u1ea1n v\u1eeba v\u00e0o ph\u00f2ng s\u1ea1ch l\u00fac 7 s\u00e1ng. Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u s\u1ea3n xu\u1ea5t, b\u1ea1n:<\/span><\/p>\n

    \n
  1. Ki\u1ec3m tra settle plate t\u1eeb h\u00f4m qua \u2192 <1 CFU\/plate \u2713<\/span><\/li>\n
  2. Phun QUAT l\u00ean s\u00e0n, t\u01b0\u1eddng, b\u00e0n c\u00f4ng vi\u1ec7c (n\u1ed3ng \u0111\u1ed9 1:256)<\/span><\/li>\n
  3. Ch\u1edd 15 ph\u00fat contact time<\/span><\/li>\n
  4. Lau b\u1eb1ng kh\u0103n microfiber s\u1ea1ch (kh\u00f4ng r\u1eeda l\u1ea1i v\u00ec mu\u1ed1n duy tr\u00ec b\u1ec1 m\u1eb7t s\u1ea1ch)<\/span><\/li>\n
  5. L\u1ed6I: Qu\u00ean r\u1eeda s\u1ea1ch d\u01b0 l\u01b0\u1ee3ng Quat b\u1eb1ng WFI<\/span><\/li>\n<\/ol>\n

    K\u1ebft qu\u1ea3: D\u01b0 l\u01b0\u1ee3ng Quat t\u00edch l\u0169y h\u00e0ng ng\u00e0y \u2192 Tu\u1ea7n th\u1ee9 2, vi sinh b\u1eaft \u0111\u1ea7u t\u0103ng \u2192 Tu\u1ea7n th\u1ee9 4, vi sinh Gram \u00e2m xu\u1ea5t hi\u1ec7n (kh\u00e1ng Quat) \u2192 Ph\u1ea3i chuy\u1ec3n sang h\u00f3a ch\u1ea5t di\u1ec7t b\u00e0o t\u1eed\u00a0<\/span><\/p>\n

    Gi\u1ea3i ph\u00e1p \u0111\u00fang: R\u1eeda s\u1ea1ch b\u1eb1ng WFI sau ti\u1ebfp x\u00fac 15 ph\u00fat, ho\u1eb7c lu\u00e2n phi\u00ean Quat v\u1edbi H2O2\/Sporicide \u0111\u1ec3 tr\u00e1nh t\u00edch l\u0169y.<\/span><\/p>\n

    Xem th\u00eam t\u1ea1i <\/span><\/i>DUNG D\u1ecaCH QT QUAT<\/span><\/i><\/a> \u0111\u1ec3 t\u00ecm hi\u1ec3u t\u1ef7 l\u1ec7 pha lo\u00e3ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng \u0111\u00fang.<\/span><\/i><\/p>\n

    Nh\u1eefng H\u1ea1n Ch\u1ebf V\u00e0 Sai L\u1ea7m Khi D\u00f9ng Quat \u2014 Biofilm, Kh\u00e1ng H\u00f3a Ch\u1ea5t, M\u00f4i Tr\u01b0\u1eddng<\/b><\/h2>\n

    H\u1ea7u h\u1ebft c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c g\u1eb7p ph\u1ea3i nh\u1eefng v\u1ea5n \u0111\u1ec1 kh\u00f4ng l\u01b0\u1eddng tr\u01b0\u1edbc \u0111\u01b0\u1ee3c. Quat c\u00f3 nh\u1eefng h\u1ea1n ch\u1ebf r\u00f5 r\u00e0ng m\u00e0 n\u1ebfu kh\u00f4ng qu\u1ea3n l\u00fd \u0111\u00fang, s\u1ebd g\u00e2y h\u1eadu qu\u1ea3 nghi\u00eam tr\u1ecdng nh\u01b0 sau<\/span><\/p>\n

    H\u1ea1n Ch\u1ebf #1: Biofilm \u2014 N\u01a1i Quat Th\u1ea5t B\u1ea1i Ho\u00e0n To\u00e0n<\/b><\/h3>\n

    H\u00e3y t\u01b0\u1edfng t\u01b0\u1ee3ng m\u1ed9t l\u1edbp d\u1ea7u m\u1ecf b\u00e1m tr\u00ean m\u1eb7t n\u01b0\u1edbc \u2014 \u0111\u00f3 c\u01a1 b\u1ea3n l\u00e0 nh\u1eefng g\u00ec biofilm l\u00e0m. Biofilm l\u00e0 nh\u1eefng c\u1ed9ng \u0111\u1ed3ng vi sinh v\u1eadt b\u00e1m d\u00ednh tr\u00ean b\u1ec1 m\u1eb7t (s\u00e0n, t\u01b0\u1eddng, \u1ed1ng n\u01b0\u1edbc) v\u1edbi l\u1edbp ma tr\u1eadn b\u1ea3o v\u1ec7 b\u00ean ngo\u00e0i g\u1ecdi l\u00e0 EPS (Extracellular Polymeric Substance \u2014 ch\u1ea5t \u0111a ph\u1ea7n l\u00e0 carbohydrate v\u00e0 protein).<\/span><\/p>\n

    Khi b\u1ea1n phun Quat l\u00ean b\u1ec1 m\u1eb7t c\u00f3 biofilm, \u0111i\u1ec1u g\u00ec x\u1ea3y ra?\u00a0<\/b><\/h4>\n

    Quat ch\u1ec9 c\u00f3 th\u1ec3 gi\u1ebft \u0111\u01b0\u1ee3c vi khu\u1ea9n n\u1eb1m \u1edf b\u1ec1 m\u1eb7t ngo\u00e0i c\u1ee7a biofilm. L\u1edbp EPS d\u00e0y \u0111\u1eb7c s\u1ebd c\u1ea3n tr\u1edf Quat th\u1ea5m v\u00e0o s\u00e2u b\u00ean trong \u2014 k\u1ebft qu\u1ea3 l\u00e0 nh\u1eefng vi sinh b\u00ean trong biofilm s\u1ed1ng s\u00f3t, ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n, v\u00e0 sau m\u1ed9t v\u00e0i ng\u00e0y, biofilm s\u1ebd l\u1ea1i ph\u1ee5c h\u1ed3i.<\/span><\/p>\n

    V\u00ed d\u1ee5 th\u1ef1c t\u1ebf: M\u1ed9t nh\u00e0 m\u00e1y s\u1ea3n xu\u1ea5t ch\u1ebf ph\u1ea9m protein ph\u00e1t hi\u1ec7n Salmonella v\u00e0 Listeria t\u1ed3n t\u1ea1i dai d\u1eb3ng d\u01b0\u1edbi biofilm \u1edf \u1ed1ng tho\u00e1t n\u01b0\u1edbc. D\u00f9 h\u1ecd d\u00f9ng Quat h\u00e0ng ng\u00e0y trong 3 th\u00e1ng, vi sinh v\u1eabn kh\u00f4ng bi\u1ebfn m\u1ea5t.\u00a0<\/span><\/p>\n

    L\u00fd do: Biofilm kh\u00f4ng b\u1ecb lo\u1ea1i b\u1ecf s\u1ea1ch, v\u00e0 Quat kh\u00f4ng th\u1ea5m qua \u0111\u01b0\u1ee3c. Gi\u1ea3i ph\u00e1p cu\u1ed1i c\u00f9ng l\u00e0 l\u00e0m s\u1ea1ch c\u01a1 h\u1ecdc tr\u01b0\u1edbc (d\u00f9ng b\u00e0n ch\u1ea3i, n\u01b0\u1edbc \u00e1p l\u1ef1c cao) \u0111\u1ec3 lo\u1ea1i b\u1ecf biofilm, r\u1ed3i m\u1edbi d\u00f9ng Quat kh\u1eed khu\u1ea9n. \u0110\u00f3 g\u1ecdi l\u00e0 “Clean then Disinfect” \u2014 ti\u00eau chu\u1ea9n GMP.<\/span><\/p>\n

    H\u1ea1n Ch\u1ebf #2: Kh\u00e1ng H\u00f3a Ch\u1ea5t \u2014 D\u01b0 L\u01b0\u1ee3ng Quat G\u00e2y Ch\u1ecdn L\u1ecdc Gen Kh\u00e1ng<\/b><\/h3>\n

    \u0110\u00e2y l\u00e0 h\u1ea1n ch\u1ebf nguy hi\u1ec3m nh\u1ea5t m\u00e0 \u00edt ng\u01b0\u1eddi nh\u1eadn ra. Khi b\u1ea1n \u0111\u1ec3 l\u1ea1i d\u01b0 l\u01b0\u1ee3ng Quat tr\u00ean b\u1ec1 m\u1eb7t sau khi v\u1ec7 sinh, m\u1ed9t \u0111i\u1ec1u x\u1ea3y ra: n\u1ed3ng \u0111\u1ed9 Quat t\u1ed3n l\u1ea1i d\u01b0\u1edbi m\u1ee9c ti\u00eau di\u1ec7t ho\u00e0n to\u00e0n (sub-inhibitory concentration) \u2014 n\u00f3 kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 gi\u1ebft vi sinh, nh\u01b0ng \u0111\u1ee7 \u0111\u1ec3 k\u00edch th\u00edch ch\u00fang ph\u00e1t tri\u1ec3n kh\u1ea3 n\u0103ng kh\u00e1ng h\u00f3a ch\u1ea5t.<\/span><\/p>\n

    C\u01a1 ch\u1ebf n\u00e0y g\u1ecdi l\u00e0 selective pressure (\u00e1p l\u1ef1c ch\u1ecdn l\u1ecdc). Vi sinh v\u1eadt c\u00f3 gen qacE (gen m\u00e3 h\u00f3a cho efflux pump \u2014 nh\u1eefng c\u01a1 ch\u1ebf n\u00e0y gi\u00fap lo\u1ea1i b\u1ecf Quat t\u1eeb b\u00ean trong t\u1ebf b\u00e0o) s\u1ebd \u0111\u01b0\u1ee3c ch\u1ecdn l\u1ecdc v\u00e0 ph\u00e1t tri\u1ec3n m\u1ea1nh h\u01a1n. Sau 2-3 th\u00e1ng d\u00f9ng Quat h\u00e0ng ng\u00e0y, vi sinh v\u1eadt kh\u00e1ng h\u00f3a ch\u1ea5t s\u1ebd tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn trong ph\u00f2ng s\u1ea1ch c\u1ee7a b\u1ea1n.<\/span><\/p>\n

    V\u00e0 v\u1ea5n \u0111\u1ec1 th\u1eadm t\u1ec7 h\u01a1n l\u00e0 kh\u00e1ng ch\u00e9o (cross-resistance): Vi sinh v\u1eadt kh\u00e1ng Quat th\u01b0\u1eddng c\u0169ng kh\u00e1ng c\u00e1c nh\u00f3m kh\u00e1ng sinh kh\u00e1c (fluoroquinolones, macrolides), v\u00ec ch\u00fang s\u1eed d\u1ee5ng c\u01a1 ch\u1ebf efflux pump chung. N\u1ebfu m\u1ed9t trong nh\u1eefng vi sinh n\u00e0y l\u1ecdt v\u00e0o s\u1ea3n ph\u1ea9m, kh\u00e1ng sinh \u0111i\u1ec1u tr\u1ecb s\u1ebd v\u00f4 hi\u1ec7u \u2014 r\u1ee7i ro nghi\u00eam tr\u1ecdng cho b\u1ec7nh nh\u00e2n cu\u1ed1i c\u00f9ng s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m.<\/span><\/p>\n

    H\u1ea1n Ch\u1ebf #3: M\u00f4i Tr\u01b0\u1eddng \u2014 N\u01b0\u1edbc C\u1ee9ng & Ch\u1ea5t Anionic L\u00e0m Gi\u1ea3m Ho\u1ea1t T\u00ednh Quat<\/b><\/h3>\n

    Kh\u00f4ng ph\u1ea3i l\u00fac n\u00e0o Quat c\u0169ng ho\u1ea1t \u0111\u1ed9ng nh\u01b0 ti\u00eau chu\u1ea9n tr\u00ean gi\u1ea5y. M\u00f4i tr\u01b0\u1eddng xung quanh c\u00f3 th\u1ec3 ph\u00e1 h\u1ee7y hi\u1ec7u qu\u1ea3 c\u1ee7a n\u00f3 m\u1ed9t c\u00e1ch im l\u1eb7ng.<\/span><\/p>\n

    N\u01b0\u1edbc c\u1ee9ng (ch\u1ee9a calcium Ca\u00b2\u207a v\u00e0 magnesium Mg\u00b2\u207a) s\u1ebd k\u1ebft t\u1ee7a v\u1edbi Quat (v\u00ec Quat mang \u0111i\u1ec7n t\u00edch d\u01b0\u01a1ng), h\u00ecnh th\u00e0nh c\u00e1c h\u1ee3p ch\u1ea5t kh\u00f4ng h\u00f2a tan. K\u1ebft qu\u1ea3: n\u1ed3ng \u0111\u1ed9 Quat th\u1ef1c t\u1ebf ch\u1ec9 c\u00f2n 50-70% so v\u1edbi n\u1ed3ng \u0111\u1ed9 mong mu\u1ed1n.\u00a0<\/span><\/p>\n

    N\u1ebfu b\u1ea1n pha lo\u00e3ng Quat<\/b> 1:256 (nh\u01b0 h\u01b0\u1edbng d\u1eabn) b\u1eb1ng n\u01b0\u1edbc c\u1ee9ng, n\u1ed3ng \u0111\u1ed9 th\u1ef1c t\u1ebf c\u00f3 th\u1ec3 ch\u1ec9 b\u1eb1ng 1:400 \u2014 qu\u00e1 y\u1ebfu \u0111\u1ec3 di\u1ec7t vi sinh hi\u1ec7u qu\u1ea3.<\/span><\/p>\n

    Surfactant anionic (t\u1eeb x\u00e0 ph\u00f2ng, d\u1ea7u, n\u01b0\u1edbc r\u1eeda tay) c\u1ea1nh tranh v\u1edbi vi sinh v\u1eadt \u0111\u1ec3 b\u00e1m Quat. Khi c\u1ea1nh tranh, Quat s\u1ebd g\u1eafn v\u00e0o surfactant thay v\u00ec v\u00e0o vi sinh \u2014 \u0111i\u1ec1u n\u00e0y l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n.<\/span><\/p>\n

    D\u01b0 l\u01b0\u1ee3ng Quat b\u1ecb oxidation (ti\u1ebfp x\u00fac v\u1edbi oxygen, \u00e1nh s\u00e1ng) s\u1ebd b\u1ecb ph\u00e2n h\u1ee7y, t\u1ea1o ra c\u00e1c s\u1ea3n ph\u1ea9m trung gian kh\u00f4ng ho\u00e0n to\u00e0n b\u1ecb lo\u1ea1i b\u1ecf, d\u1eabn \u0111\u1ebfn t\u00edch t\u1ee5 h\u1ea1t tr\u00ean b\u1ec1 m\u1eb7t \u2014 \u00f4 nhi\u1ec5m mu\u00f4n v\u00e0n l\u1ea7n t\u1ec7 h\u01a1n l\u00e0 vi sinh s\u1ea1ch s\u1ebd.<\/span><\/p>\n

    Quat Trong Ch\u01b0\u01a1ng Tr\u00ecnh Lu\u00e2n Phi\u00ean H\u00f3a Ch\u1ea5t \u2014 T\u1ea1i Sao K\u1ebft H\u1ee3p L\u00e0 Gi\u1ea3i Ph\u00e1p \u0110\u00fang<\/b><\/h2>\n

    T\u1edbi \u0111\u00e2y, b\u1ea1n c\u00f3 th\u1ec3 \u0111ang ngh\u0129: “N\u1ebfu Quat c\u00f3 qu\u00e1 nhi\u1ec1u h\u1ea1n ch\u1ebf, t\u1ea1i sao c\u00f2n d\u00f9ng n\u00f3?” <\/strong><\/span><\/p>\n

    \"luan-phien-quat-kiem-soat-vi-sinh\"
    Quat ki\u1ec3m so\u00e1t vi sinh trong ch\u01b0\u01a1ng tr\u00ecnh lu\u00e2n phi\u00ean<\/em><\/figcaption><\/figure>\n

    C\u00e2u tr\u1ea3 l\u1eddi n\u1eb1m \u1edf c\u00e1ch b\u1ea1n s\u1eed d\u1ee5ng n\u00f3 <\/b>\u2014 kh\u00f4ng ph\u1ea3i d\u00f9ng m\u1ed9t m\u00ecnh, m\u00e0 k\u1ebft h\u1ee3p n\u00f3 v\u1edbi chi\u1ebfn l\u01b0\u1ee3c r\u1ed9ng h\u01a1n.<\/span><\/p>\n

    T\u1ea1i Sao Kh\u00f4ng D\u00f9ng Quat H\u00e0ng Ng\u00e0y?<\/b><\/h3>\n

    D\u00f9ng Quat h\u00e0ng ng\u00e0y d\u1eabn \u0111\u1ebfn:<\/span><\/p>\n

      \n
    1. D\u01b0 l\u01b0\u1ee3ng t\u00edch t\u1ee5 h\u00e0ng ng\u00e0y (kh\u00f4ng k\u1ecbp r\u1eeda s\u1ea1ch)<\/span><\/li>\n
    2. N\u1ed3ng \u0111\u1ed9 sub-inhibitory \u2192 K\u00edch th\u00edch qacE gen<\/span><\/li>\n
    3. Vi sinh kh\u00e1ng h\u00f3a ch\u1ea5t t\u0103ng t\u1eeb tu\u1ea7n 2-3<\/span><\/li>\n
    4. Hi\u1ec7u qu\u1ea3 Quat gi\u1ea3m t\u1eeb >4 log xu\u1ed1ng <2 log trong th\u00e1ng th\u1ee9 2-3<\/span><\/li>\n
    5. Kh\u00e1ng ch\u00e9o v\u1edbi kh\u00e1ng sinh x\u1ea3y ra<\/span><\/li>\n<\/ol>\n

      K\u1ebft qu\u1ea3: B\u1ea1n c\u00f3 v\u1ebb nh\u01b0 \u0111ang ki\u1ec3m so\u00e1t vi sinh (h\u00e0ng ng\u00e0y v\u1ec7 sinh b\u1eb1ng Quat), nh\u01b0ng th\u1ef1c ch\u1ea5t nh\u1eefng vi sinh v\u1eadt c\u00f3 \u0111\u1eb7c t\u00ednh kh\u00e1ng h\u00f3a ch\u1ea5t v\u1eabn \u0111ang ph\u00e1t tri\u1ec3n th\u1ea7m l\u1eb7ng. Khi x\u1ea3y ra s\u1ef1 c\u1ed1 nh\u01b0 vi sinh kh\u00e1ng ch\u00e9o, quy tr\u00ecnh kh\u1eed khu\u1ea9n n\u00ean \u00e1p d\u1ee5ng lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t di\u1ec7t b\u00e0o t\u1eed ho\u1eb7c gi\u1eef IPA v\u00e0 Quat\u00a0<\/span><\/p>\n

      Chi\u1ebfn L\u01b0\u1ee3c Lu\u00e2n Phi\u00ean: Quat + Sporicide + H2O2<\/b><\/h3>\n

      Thay v\u00ec d\u00f9ng Quat h\u00e0ng ng\u00e0y, vi\u1ec7c lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t n\u00ean theo m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c c\u00f3 k\u1ebf ho\u1ea1ch c\u1ee5 th\u1ec3:<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
      Ng\u00e0y<\/b><\/td>\nH\u00f3a ch\u1ea5t ch\u00ednh<\/b><\/td>\nS\u00e0n<\/b><\/td>\nT\u01b0\u1eddng<\/b><\/td>\nTr\u1ea7n<\/b><\/td>\nThi\u1ebft b\u1ecb \/ b\u1ec1 m\u1eb7t l\u00e0m vi\u1ec7c<\/b><\/td>\n<\/tr>\n
      Th\u1ee9 2<\/span><\/td>\nQuat<\/b><\/td>\nH\u1eb1ng ng\u00e0y<\/span><\/td>\n2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\nTheo l\u1ecbch \/ shutdown<\/span><\/td>\nTr\u01b0\u1edbc & sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n
      Th\u1ee9 3<\/span><\/td>\nQuat<\/b><\/td>\nH\u1eb1ng ng\u00e0y<\/span><\/td>\n2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\nTheo l\u1ecbch \/ shutdown<\/span><\/td>\nTr\u01b0\u1edbc & sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n
      Th\u1ee9 4<\/span><\/td>\nH2O2 3%<\/b><\/td>\nH\u1eb1ng ng\u00e0y<\/span><\/td>\n2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\nTheo l\u1ecbch \/ shutdown<\/span><\/td>\nTr\u01b0\u1edbc & sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n
      Th\u1ee9 5<\/span><\/td>\nQuat<\/b><\/td>\nH\u1eb1ng ng\u00e0y<\/span><\/td>\n2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\nTheo l\u1ecbch \/ shutdown<\/span><\/td>\nTr\u01b0\u1edbc & sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n
      Th\u1ee9 6<\/span><\/td>\nQuat<\/b><\/td>\nH\u1eb1ng ng\u00e0y<\/span><\/td>\n2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\nTheo l\u1ecbch \/ shutdown<\/span><\/td>\nTr\u01b0\u1edbc & sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n
      Th\u1ee9 7<\/span><\/td>\nH2O2 3%<\/b><\/td>\nH\u1eb1ng ng\u00e0y<\/span><\/td>\n2\u20133 l\u1ea7n\/tu\u1ea7n<\/span><\/td>\nTheo l\u1ecbch \/ shutdown<\/span><\/td>\nTr\u01b0\u1edbc & sau s\u1eed d\u1ee5ng<\/span><\/td>\n<\/tr>\n
      Ch\u1ee7 nh\u1eadt \/ ng\u00e0y shutdown<\/span><\/td>\nSporicide<\/b><\/td>\n\u00c1p d\u1ee5ng to\u00e0n b\u1ed9<\/span><\/td>\n\u00c1p d\u1ee5ng<\/span><\/td>\n\u00c1p d\u1ee5ng n\u1ebfu c\u00f3 l\u1ecbch<\/span><\/td>\n\u00c1p d\u1ee5ng to\u00e0n b\u1ed9<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      C\u00e1ch di\u1ec5n \u0111\u1ea1t ng\u1eafn g\u1ecdn \u0111\u1ec3 \u0111\u01b0a v\u00e0o SOP<\/b><\/h2>\n

      Chi\u1ebfn l\u01b0\u1ee3c lu\u00e2n phi\u00ean 1 tu\u1ea7n:<\/b><\/p>\n