{"id":9674,"date":"2026-04-07T18:15:17","date_gmt":"2026-04-07T18:15:17","guid":{"rendered":"https:\/\/sepro.vn\/?p=9674"},"modified":"2026-04-07T18:15:17","modified_gmt":"2026-04-07T18:15:17","slug":"nhung-sai-lam-pho-bien-ve-quat","status":"publish","type":"post","link":"https:\/\/sepro.vn\/vi\/nhung-sai-lam-pho-bien-ve-quat\/","title":{"rendered":"Nh\u1eefng Sai L\u1ea7m Ph\u1ed5 Bi\u1ebfn V\u1ec1 QUAT Trong Ph\u00f2ng S\u1ea1ch GMP \u2014 V\u00e0 V\u00ec Sao Nhi\u1ec1u Nh\u00e0 M\u00e1y D\u01b0\u1ee3c V\u1eabn L\u1eb7p L\u1ea1i"},"content":{"rendered":"

Theo Sepro<\/a><\/strong> bi\u1ebft trong th\u1ef1c t\u1ebf v\u1eadn h\u00e0nh, nhi\u1ec1u c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t d\u01b0\u1ee3c ph\u1ea9m s\u1eed d\u1ee5ng h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n (QUAT) nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n ch\u00ednh trong ch\u01b0\u01a1ng tr\u00ecnh kh\u1eed khu\u1ea9n ph\u00f2ng s\u1ea1ch, do c\u00e1c \u01b0u \u0111i\u1ec3m nh\u01b0 chi ph\u00ed th\u1ea5p, t\u00e1c d\u1ee5ng nhanh v\u00e0 m\u1ee9c \u0111\u1ed9 \u0103n m\u00f2n th\u1ea5p.<\/span><\/p>\n

Tuy nhi\u00ean, vi\u1ec7c ph\u1ee5 thu\u1ed9c v\u00e0o QUAT m\u00e0 kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u1ea7y \u0111\u1ee7 c\u00e1c y\u1ebfu t\u1ed1 li\u00ean quan c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng kho\u1ea3ng tr\u1ed1ng trong ki\u1ec3m so\u00e1t nhi\u1ec5m. C\u00e1c v\u1ea5n \u0111\u1ec1 th\u01b0\u1eddng g\u1eb7p bao g\u1ed3m t\u00edch l\u0169y d\u01b0 l\u01b0\u1ee3ng tr\u00ean b\u1ec1 m\u1eb7t, hi\u1ec7u qu\u1ea3 h\u1ea1n ch\u1ebf \u0111\u1ed1i v\u1edbi biofilm, v\u00e0 ch\u01b0\u01a1ng tr\u00ecnh th\u1ea9m \u0111\u1ecbnh (validation) ch\u01b0a bao qu\u00e1t \u0111\u1ea7y \u0111\u1ee7 c\u00e1c \u0111i\u1ec1u ki\u1ec7n th\u1ef1c t\u1ebf.<\/span><\/p>\n

Nh\u1eefng y\u1ebfu t\u1ed1 n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n, g\u00f3p ph\u1ea7n l\u00e0m t\u0103ng nguy c\u01a1 th\u00edch nghi c\u1ee7a vi sinh v\u1eadt, \u00f4 nhi\u1ec5m s\u1ea3n ph\u1ea9m, ho\u1eb7c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng l\u00f4 s\u1ea3n xu\u1ea5t.<\/span><\/p>\n

B\u00e0i vi\u1ebft n\u00e0y<\/a><\/strong> s\u1ebd ch\u1ec9 ra 5 sai l\u1ea7m ph\u1ed5 bi\u1ebfn v\u1ec1 QUAT m\u00e0 b\u1ea1n c\u00f3 th\u1ec3 \u0111ang m\u1eafc ph\u1ea3i m\u00e0 kh\u00f4ng bi\u1ebft, c\u00f9ng v\u1edbi c\u00e1ch \u0111\u1ec3 tr\u00e1nh ch\u00fang.<\/span><\/p>\n

L\u1ee3i \u00cdch C\u1ee7a QUAT V\u00e0 Gi\u1edbi H\u1ea1n Th\u1ef1c T\u1ebf<\/b><\/h2>\n

Tr\u01b0\u1edbc khi ph\u00e2n t\u00edch c\u00e1c sai s\u00f3t, c\u1ea7n hi\u1ec3u c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n n\u00e0y. QUAT (h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n) l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n kh\u1eed khu\u1ea9n kh\u00f4ng oxy h\u00f3a, ho\u1ea1t \u0111\u1ed9ng th\u00f4ng qua t\u01b0\u01a1ng t\u00e1c t\u0129nh \u0111i\u1ec7n. Ph\u00e2n t\u1eed QUAT mang \u0111i\u1ec7n t\u00edch d\u01b0\u01a1ng b\u1ecb h\u00fat v\u00e0o m\u00e0ng t\u1ebf b\u00e0o vi khu\u1ea9n (mang \u0111i\u1ec7n t\u00edch \u00e2m), x\u00e2m nh\u1eadp v\u00e0o l\u1edbp lipid bilayer, ph\u00e1 v\u1ee1 c\u1ea5u tr\u00fac v\u00e0 g\u00e2y r\u00f2 r\u1ec9 n\u1ed9i b\u00e0o.<\/span><\/p>\n

QUAT c\u00f3 hi\u1ec7u qu\u1ea3 cao \u0111\u1ed1i v\u1edbi vi khu\u1ea9n t\u1ef1 do, v\u1edbi th\u1eddi gian t\u00e1c \u0111\u1ed9ng nhanh (5\u201310 ph\u00fat), chi ph\u00ed th\u1ea5p, \u00edt \u0103n m\u00f2n v\u00e0 m\u1ee9c k\u00edch \u1ee9ng t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p. Nh\u01b0ng gi\u1edbi h\u1ea1n c\u1ee7a n\u00f3 c\u0169ng r\u1ea5t l\u1edbn: k\u00e9m hi\u1ec7u qu\u1ea3 tr\u00ean biofilm (nh\u1eefng c\u1ed9ng \u0111\u1ed3ng vi khu\u1ea9n b\u00e1m d\u00ednh c\u00f3 l\u1edbp ma tr\u1eadn b\u1ea3o v\u1ec7), d\u1ec5 b\u1ecb t\u01b0\u01a1ng t\u00e1c v\u1edbi ch\u1ea5t b\u1ea9n m\u00f4i tr\u01b0\u1eddng, c\u00f3 th\u1ec3 g\u00e2y kh\u00e1ng ch\u00e9o \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p.<\/span><\/p>\n

Vi\u1ec7c nh\u1eadn di\u1ec7n r\u00f5 c\u00e1c gi\u1edbi h\u1ea1n n\u00e0y l\u00e0 c\u01a1 s\u1edf \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 v\u00e0 t\u1ed1i \u01b0u ch\u01b0\u01a1ng tr\u00ecnh kh\u1eed khu\u1ea9n trong ph\u00f2ng s\u1ea1ch GMP.<\/span><\/p>\n

Gi\u1edbi H\u1ea1n C\u1ee7a Test In Vitro So V\u1edbi \u0110i\u1ec1u Ki\u1ec7n Ph\u00f2ng S\u1ea1ch Th\u1ef1c T\u1ebf<\/b><\/h2>\n

Test In Vitro l\u00e0 g\u00ec? \u0110\u00f3 l\u00e0 c\u00e1c \u0111\u00e1nh gi\u00e1 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong m\u00f4i tr\u01b0\u1eddng ph\u00f2ng th\u00ed nghi\u1ec7m, trong \u1ed1ng nghi\u1ec7m ho\u1eb7c petri dish, v\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t v\u00e0 \u0111\u01a1n gi\u1ea3n h\u00f3a. N\u00f3 kh\u00e1c ho\u00e0n to\u00e0n v\u1edbi test “in vivo” (tr\u00ean c\u01a1 th\u1ec3 s\u1ed1ng) hay “in situ” (trong m\u00f4i tr\u01b0\u1eddng th\u1ef1c t\u1ebf).<\/span><\/p>\n

Trong c\u00e1c th\u1eed nghi\u1ec7m in vitro, QUAT th\u01b0\u1eddng cho th\u1ea5y hi\u1ec7u qu\u1ea3 di\u1ec7t khu\u1ea9n cao. Tuy nhi\u00ean, khi \u00e1p d\u1ee5ng trong ph\u00f2ng s\u1ea1ch, hi\u1ec7u qu\u1ea3 c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1ea1t t\u01b0\u01a1ng \u0111\u01b0\u01a1ng do s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 tr\u1ea1ng th\u00e1i t\u1ed3n t\u1ea1i c\u1ee7a vi sinh v\u1eadt.<\/span><\/p>\n

L\u00fd do ch\u00ednh n\u1eb1m \u1edf c\u00e1ch vi sinh v\u1eadt t\u1ed3n t\u1ea1i trong hai m\u00f4i tr\u01b0\u1eddng kh\u00e1c nhau. Trong ph\u00f2ng th\u00ed nghi\u1ec7m, vi sinh v\u1eadt \u0111\u01b0\u1ee3c test \u1edf tr\u1ea1ng th\u00e1i “t\u1ef1 do l\u01a1 l\u1eedng” trong dung d\u1ecbch, d\u1ec5 ti\u1ebfp x\u00fac v\u1edbi QUAT, d\u1ec5 b\u1ecb ti\u00eau di\u1ec7t. Nh\u01b0ng trong ph\u00f2ng s\u1ea1ch th\u1ef1c t\u1ebf, vi sinh v\u1eadt t\u1ed3n t\u1ea1i d\u01b0\u1edbi d\u1ea1ng biofilm (nh\u1eefng c\u1ed9ng \u0111\u1ed3ng b\u00e1m d\u00ednh tr\u00ean b\u1ec1 m\u1eb7t v\u1edbi l\u1edbp ma tr\u1eadn b\u1ea3o v\u1ec7). Hi\u1ec7u qu\u1ea3 c\u1ee7a QUAT tr\u00ean biofilm gi\u1ea3m t\u1edbi 50-80% so v\u1edbi tr\u1ea1ng th\u00e1i t\u1ef1 do.<\/span><\/p>\n

Th\u00eam v\u00e0o \u0111\u00f3, d\u1eef li\u1ec7u t\u1eeb ph\u00f2ng th\u00ed nghi\u1ec7m (in vitro) kh\u00e1c ho\u00e0n to\u00e0n v\u1edbi d\u1eef li\u1ec7u t\u1eeb \u0111i\u1ec1u ki\u1ec7n d\u00f9ng th\u1ef1c t\u1ebf (in use). M\u1ed9t b\u00e0i nghi\u00ean c\u1ee9u t\u1eeb PubMed ch\u1ec9 ra “relatively few studies have been conducted to assess their efficacy in practice” \u2014 h\u1ea7u h\u1ebft \u0111\u00e1nh gi\u00e1 QUAT d\u1ef1a tr\u00ean ph\u00f2ng th\u00ed nghi\u1ec7m, trong khi d\u1eef li\u1ec7u th\u1ef1c t\u1ebf t\u1eeb ph\u00f2ng s\u1ea1ch c\u00f2n \u00edt h\u01a1n r\u1ea5t nhi\u1ec1u.<\/span><\/p>\n

Do \u0111\u00f3, d\u1eef li\u1ec7u in vitro th\u01b0\u1eddng \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n trong \u0111i\u1ec1u ki\u1ec7n t\u1ed1i \u01b0u v\u00e0 c\u00f3 xu h\u01b0\u1edbng cao h\u01a1n so v\u1edbi th\u1ef1c t\u1ebf v\u1eadn h\u00e0nh. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn vi\u1ec7c \u0111\u00e1nh gi\u00e1 qu\u00e1 m\u1ee9c hi\u1ec7u qu\u1ea3 c\u1ee7a QUAT n\u1ebfu kh\u00f4ng xem x\u00e9t \u0111\u1ea7y \u0111\u1ee7 c\u00e1c y\u1ebfu t\u1ed1 th\u1ef1c t\u1ebf trong ph\u00f2ng s\u1ea1ch. Cho th\u1ea5y kho\u1ea3ng c\u00e1ch \u0111\u00e1ng k\u1ec3 gi\u1eefa d\u1eef li\u1ec7u ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 hi\u1ec7u qu\u1ea3 th\u1ef1c t\u1ebf.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
\u0110i\u1ec1u Ki\u1ec7n<\/b><\/td>\nTest In Vitro (Ph\u00f2ng Th\u00ed Nghi\u1ec7m)<\/b><\/td>\nPh\u00f2ng S\u1ea1ch Th\u1ef1c T\u1ebf<\/b><\/td>\n<\/tr>\n
Tr\u1ea1ng th\u00e1i vi sinh<\/span><\/td>\nVi khu\u1ea9n t\u1ef1 do l\u01a1 l\u1eedng<\/span><\/td>\nVi khu\u1ea9n b\u00e1m d\u00ednh biofilm<\/span><\/td>\n<\/tr>\n
Ti\u1ebfp x\u00fac v\u1edbi QUAT<\/span><\/td>\n100% tr\u1ef1c ti\u1ebfp<\/span><\/td>\n20-50% (ma tr\u1eadn EPS c\u1ea3n tr\u1edf)<\/span><\/td>\n<\/tr>\n
Hi\u1ec7u qu\u1ea3 di\u1ec7t khu\u1ea9n<\/span><\/td>\n99%+<\/span><\/td>\n20-50%<\/span><\/td>\n<\/tr>\n
D\u01b0 l\u01b0\u1ee3ng<\/span><\/td>\nKi\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c<\/span><\/td>\nKh\u00f4ng ki\u1ec3m so\u00e1t, t\u00edch l\u0169y<\/span><\/td>\n<\/tr>\n
Bi\u1ebfn s\u1ed1 m\u00f4i tr\u01b0\u1eddng<\/span><\/td>\n\u00cdt (n\u01b0\u1edbc tinh khi\u1ebft, pH ki\u1ec3m so\u00e1t)<\/span><\/td>\nNhi\u1ec1u (n\u01b0\u1edbc c\u1ee9ng, ch\u1ea5t b\u00e9o)<\/span><\/td>\n<\/tr>\n
Th\u1eddi gian<\/span><\/td>\nV\u00e0i ph\u00fat \u0111\u1ebfn gi\u1edd<\/span><\/td>\nTu\u1ea7n sang th\u00e1ng<\/span><\/td>\n<\/tr>\n
K\u1ebft qu\u1ea3 th\u1ef1c t\u1ebf<\/span><\/td>\nHi\u1ec7u qu\u1ea3 cao tr\u00ean gi\u1ea5y<\/span><\/td>\nHi\u1ec7u qu\u1ea3 th\u1ea5p khi \u00e1p d\u1ee5ng<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0110i\u1ec3m Kh\u00e1c Bi\u1ec7t Gi\u1eefa QUAT, PAA V\u00e0 H2O2<\/b><\/h2>\n

\u0110\u1ec3 t\u1ed1i \u01b0u h\u00f3a chi\u1ebfn l\u01b0\u1ee3c kh\u1eed khu\u1ea9n, c\u1ea7n hi\u1ec3u r\u00f5 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng, ph\u1ed5 di\u1ec7t khu\u1ea9n v\u00e0 gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng c\u1ee7a ba h\u00f3a ch\u1ea5t ch\u1ee7 l\u1ef1c trong ph\u00f2ng s\u1ea1ch GMP.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
Ti\u00eau Ch\u00ed<\/b><\/td>\nQUAT khi d\u00f9ng tr\u00ean vi khu\u1ea9n t\u1ef1 do l\u01a1 l\u1eedng<\/b><\/td>\nQUAT khi d\u00f9ng tr\u00ean biofilm b\u00e1m d\u00ednh<\/b><\/td>\nPAA k\u1ebft h\u1ee3p H2O2<\/b><\/td>\nIPA 70%<\/b><\/td>\n<\/tr>\n
Hi\u1ec7u qu\u1ea3<\/span><\/td>\n\u226599.99% (4\u20136 log)<\/span><\/td>\n~90\u201399.9% (1\u20133 log)<\/span><\/td>\n\u226599.999% (\u22656 log)<\/span><\/td>\n~99\u201399.9%<\/span><\/td>\n<\/tr>\n
Th\u1eddi gian ti\u1ebfp x\u00fac<\/span><\/td>\n5-10 ph\u00fat<\/span><\/td>\n15-20 ph\u00fat<\/span><\/td>\n10-15 ph\u00fat<\/span><\/td>\n5-10 ph\u00fat<\/span><\/td>\n<\/tr>\n
N\u1ed3ng \u0111\u1ed9 s\u1eed d\u1ee5ng<\/span><\/td>\n0.5-1%<\/span><\/td>\n0.5-1%<\/span><\/td>\n0.2-0.35% c\u1ed9ng 25%<\/span><\/td>\n70%<\/span><\/td>\n<\/tr>\n
G\u00e2y \u0103n m\u00f2n v\u1eadt li\u1ec7u<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\nC\u00f3<\/span><\/td>\nC\u00f3 (nh\u00f4m)<\/span><\/td>\n<\/tr>\n
D\u01b0 l\u01b0\u1ee3ng<\/span><\/td>\nC\u00f3 (c\u1ea7n r\u1eeda k\u1ef9)<\/span><\/td>\nC\u00f3 (c\u1ea7n r\u1eeda k\u1ef9)<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\nKh\u00f4ng<\/span><\/td>\n<\/tr>\n
\u1ee8ng d\u1ee5ng Grade<\/span><\/td>\nC\/D<\/span><\/td>\nC\/D<\/span><\/td>\nA\/B<\/span><\/td>\nA\/B (thi\u1ebft b\u1ecb)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

QUAT c\u00f3 hi\u1ec7u qu\u1ea3 cao tr\u00ean vi khu\u1ea9n t\u1ef1 do (th\u01b0\u1eddng \u0111\u1ea1t \u22654\u20136 log reduction, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng \u226599.99%). Tuy nhi\u00ean, hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u ki\u1ec7n biofilm do h\u1ea1n ch\u1ebf khu\u1ebfch t\u00e1n v\u00e0 b\u1ea3o v\u1ec7 t\u1eeb ma tr\u1eadn EPS, v\u1edbi m\u1ee9c gi\u1ea3m th\u01b0\u1eddng ch\u1ec9 kho\u1ea3ng 1\u20133 log (\u224890\u201399.9%), th\u1ea5p h\u01a1n r\u00f5 r\u1ec7t so v\u1edbi tr\u1ea1ng th\u00e1i planktonic.<\/span><\/p>\n

Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c h\u1ec7 oxy h\u00f3a m\u1ea1nh nh\u01b0 peracetic acid (PAA) k\u1ebft h\u1ee3p hydrogen peroxide (H\u2082O\u2082) (v\u00ed d\u1ee5 nh\u01b0 c\u00f4ng s\u1ea3n ph\u1ea9m t\u1eeb STERIS Spor-Klenz, Contec PeridoxRTU, Veltek DECON-SPORE, Ecolab Disinfectant Plus, ho\u1eb7c c\u00e1c formulation PAA c\u1ee7a Noxilizer) duy tr\u00ec hi\u1ec7u qu\u1ea3 cao tr\u00ean c\u1ea3 vi khu\u1ea9n t\u1ef1 do v\u00e0 biofilm, v\u1edbi kh\u1ea3 n\u0103ng \u0111\u1ea1t \u22656 log reduction trong \u0111i\u1ec1u ki\u1ec7n s\u1eed d\u1ee5ng ph\u00f9 h\u1ee3p.<\/span><\/p>\n

IPA 70% c\u00f3 t\u1ed1c \u0111\u1ed9 t\u00e1c \u0111\u1ed9ng nhanh v\u00e0 hi\u1ec7u qu\u1ea3 t\u1ed1t tr\u00ean vi khu\u1ea9n t\u1ef1 do (\u22483\u20135 log), nh\u01b0ng kh\u00f4ng hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi b\u00e0o t\u1eed v\u00e0 h\u1ea1n ch\u1ebf \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u ki\u1ec7n biofilm.<\/span><\/p>\n

5 Sai L\u1ea7m Ch\u00ednh Khi S\u1eed D\u1ee5ng V\u00e0 \u0110\u00e1nh Gi\u00e1 QUAT<\/b><\/h2>\n
\"sai-lam-pho-bien-ve-quat-khi-su-dung-va-danh-gia\"
Sai L\u1ea7m Ch\u00ednh Khi S\u1eed D\u1ee5ng V\u00e0 \u0110\u00e1nh Gi\u00e1 QUAT<\/em><\/figcaption><\/figure>\n

Sai L\u1ea7m Th\u1ee9 Nh\u1ea5t: Ch\u1ec9 Ki\u1ec3m Tra Tr\u00ean Vi Khu\u1ea9n T\u1ef1 Do, B\u1ecf Qua Nh\u1eefng C\u1ed9ng \u0110\u1ed3ng Vi Sinh B\u00e1m D\u00ednh<\/b><\/h3>\n

QUAT c\u00f3 hi\u1ec7u qu\u1ea3 cao tr\u00ean vi khu\u1ea9n \u1edf tr\u1ea1ng th\u00e1i t\u1ef1 do (planktonic), th\u01b0\u1eddng \u0111\u1ea1t \u22654\u20136 log reduction trong \u0111i\u1ec1u ki\u1ec7n th\u1eed nghi\u1ec7m. Tuy nhi\u00ean, hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi biofilm tr\u01b0\u1edfng th\u00e0nh do s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a ma tr\u1eadn ngo\u1ea1i b\u00e0o (EPS), l\u00e0m h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng th\u00e2m nh\u1eadp c\u1ee7a h\u00f3a ch\u1ea5t. Trong \u0111i\u1ec1u ki\u1ec7n n\u00e0y, hi\u1ec7u qu\u1ea3 th\u01b0\u1eddng ch\u1ec9 \u0111\u1ea1t kho\u1ea3ng 1\u20133 log reduction.<\/span><\/p>\n

H\u1ec7 qu\u1ea3<\/strong><\/h4>\n

Vi\u1ec7c ch\u1ec9 d\u1ef1a v\u00e0o d\u1eef li\u1ec7u in vitro (planktonic) c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn \u0111\u00e1nh gi\u00e1 qu\u00e1 m\u1ee9c hi\u1ec7u qu\u1ea3 c\u1ee7a QUAT, trong khi vi sinh v\u1eadt b\u00e1m d\u00ednh v\u1eabn t\u1ed3n t\u1ea1i trong m\u00f4i tr\u01b0\u1eddng ph\u00f2ng s\u1ea1ch.<\/span><\/p>\n

L\u01b0u \u00fd quan tr\u1ecdng<\/strong><\/h4>\n

Vi\u1ec7c gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng vi khu\u1ea9n trong biofilm kh\u00f4ng \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c lo\u1ea1i b\u1ecf biofilm kh\u1ecfi b\u1ec1 m\u1eb7t. Theo US EPA, nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111\u00e1nh gi\u00e1 kh\u00f4ng \u0111o l\u01b0\u1eddng kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf c\u1ea5u tr\u00fac biofilm. N\u1ebfu biofilm v\u1eabn t\u1ed3n t\u1ea1i, vi sinh v\u1eadt c\u00f3 th\u1ec3 ph\u1ee5c h\u1ed3i v\u00e0 t\u00e1i ph\u00e1t tri\u1ec3n.<\/span><\/p>\n

Gi\u1ea3i ph\u00e1p<\/strong><\/h4>\n

Th\u1ef1c hi\u1ec7n \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n tr\u00ean biofilm theo c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ho\u1eb7c ti\u00eau chu\u1ea9n ph\u00f9 h\u1ee3p, thay v\u00ec ch\u1ec9 d\u1ef1a tr\u00ean th\u1eed nghi\u1ec7m planktonic.<\/span><\/p>\n

Xem th\u00eam t\u1ea1i <\/span><\/i>T\u00e1c \u0110\u1ed9ng C\u1ee7a QUAT Tr\u00ean Biofilm V\u00e0 Vi Sinh<\/i><\/a><\/strong> \u0111\u1ec3 hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf.<\/span><\/i><\/p>\n

Sai L\u1ea7m Th\u1ee9 Hai: B\u1ecf Qua Nh\u1eefng T\u00e1c \u0110\u1ed9ng T\u1eeb M\u00f4i Tr\u01b0\u1eddng Xung Quanh<\/b><\/h3>\n

Hi\u1ec7u qu\u1ea3 c\u1ee7a QUAT c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 b\u1edfi c\u00e1c y\u1ebfu t\u1ed1 m\u00f4i tr\u01b0\u1eddng:<\/span><\/p>\n

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