{"id":9515,"date":"2026-03-26T15:16:53","date_gmt":"2026-03-26T15:16:53","guid":{"rendered":"https:\/\/sepro.vn\/?p=9515"},"modified":"2026-03-26T15:18:53","modified_gmt":"2026-03-26T15:18:53","slug":"co-che-diet-bao-tu-cua-paa-h2o2-trong-phong-sach-gmp","status":"publish","type":"post","link":"https:\/\/sepro.vn\/vi\/co-che-diet-bao-tu-cua-paa-h2o2-trong-phong-sach-gmp\/","title":{"rendered":"C\u01a1 ch\u1ebf di\u1ec7t b\u00e0o t\u1eed c\u1ee7a PAA + H2O2 Trong Ph\u00f2ng S\u1ea1ch GMP"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Vi\u1ec7c ki\u1ec3m so\u00e1t b\u00e0o t\u1eed vi khu\u1ea9n l\u00e0 y\u00eau c\u1ea7u b\u1eaft bu\u1ed9c trong nh\u00e0 m\u00e1y d\u01b0\u1ee3c GMP. Tuy nhi\u00ean, n\u1ebfu ch\u1ec9 d\u00f9ng hydrogen peroxide (H\u2082O\u2082) ho\u1eb7c peracetic acid (PAA) c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1ea1t hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 ch\u1ee7ng vi khu\u1ea9n sinh b\u00e0o t\u1eed c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng h\u00f3a ch\u1ea5t cao. Do \u0111\u00f3, s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa PAA v\u00e0 H\u2082O\u2082 cho th\u1ea5y hi\u1ec7u qu\u1ea3 di\u1ec7t b\u00e0o t\u1eed \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng. C\u1ee5 th\u1ec3 h\u01a1n, c\u01a1 ch\u1ebf n\u00e0y li\u00ean quan \u0111\u1ebfn vi\u1ec7c t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng xuy\u00ean th\u1ea5u qua l\u1edbp b\u1ea3o v\u1ec7 c\u1ee7a b\u00e0o t\u1eed v\u00e0 ho\u1ea1t t\u00ednh oxy h\u00f3a, t\u1eeb \u0111\u00f3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t vi sinh so v\u1edbi s\u1eed d\u1ee5ng ri\u00eang l\u1ebb t\u1eebng t\u00e1c nh\u00e2n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ea1n c\u00f3 mu\u1ed1n bi\u1ebft c\u01a1 ch\u1ebf n\u00e0y ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o? <strong><a href=\"https:\/\/sepro.vn\/co-che-diet-bao-tu-cua-paa-h2o2-trong-phong-sach-gmp\/\">C\u01a1 ch\u1ebf di\u1ec7t b\u00e0o t\u1eed c\u1ee7a PAA + H2O2 <\/a><\/strong><\/span><span style=\"font-weight: 400;\">\u00a0ho\u1ea1t \u0111\u1ed9ng nh? V\u00e0 c\u1ed9ng h\u01b0\u1edfng PAA + H\u2082O\u2082 c\u00f3 th\u1ef1c s\u1ef1 an to\u00e0n cho nh\u00e2n vi\u00ean k\u1ef9 thu\u1eadt kh\u00f4ng? B\u00e0i vi\u1ebft n\u00e0y gi\u1ea3i th\u00edch c\u01a1 ch\u1ebf c\u1ed9ng h\u01b0\u1edfng chi ti\u1ebft gi\u1eefa PAA v\u00e0 H\u2082O\u2082 trong di\u1ec7t b\u00e0o t\u1eed, c\u00e1ch n\u00f3 ki\u1ec3m so\u00e1t vi sinh v\u00e0 bi\u1ebfn th\u1ec3 vi khu\u1ea9n, v\u00e0 t\u1ea1i sao s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y l\u00e0 gi\u1ea3i ph\u00e1p an to\u00e0n cho c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c.<\/span><\/p>\n<h2><b>PAA V\u00e0 H\u2082O\u2082 L\u00e0 G\u00ec V\u00e0 T\u1ea1i Sao C\u1ea7n Ph\u1ed1i H\u1ee3p<\/b><\/h2>\n<figure id=\"attachment_9528\" aria-describedby=\"caption-attachment-9528\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-9528\" src=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/2-10.png\" alt=\"co-che-diet-bao-tu-cua-paa-h2o2-la-gi-tai-sao-can-phoi-hop\" width=\"600\" height=\"600\" srcset=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/2-10.png 600w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/2-10-300x300.png 300w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/2-10-150x150.png 150w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/2-10-100x100.png 100w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9528\" class=\"wp-caption-text\"><em>C\u01a1 ch\u1ebf di\u1ec7t b\u00e0o t\u1eed c\u1ee7a PAA + H2O2 L\u00e0 G\u00ec V\u00e0 T\u1ea1i Sao C\u1ea7n Ph\u1ed1i H\u1ee3p<\/em><\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Peracetic acid (PAA) l\u00e0 h\u00f3a ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u1edbi c\u00f4ng th\u1ee9c h\u00f3a h\u1ecdc <\/span><b>CH\u2083CO\u2083H<\/b><span style=\"font-weight: 400;\">. \u0110\u00e2y l\u00e0 s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c t\u1ea1o t\u1eeb ph\u1ea3n \u1ee9ng gi\u1eefa acetic acid v\u00e0 hydrogen peroxide. PAA t\u1ed3n t\u1ea1i d\u01b0\u1edbi d\u1ea1ng dung d\u1ecbch trong n\u01b0\u1edbc, v\u00e0 n\u00f3 l\u00e0 m\u1ed9t h\u00f3a ch\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong ng\u00e0nh d\u01b0\u1ee3c ph\u1ea9m cho m\u1ee5c \u0111\u00edch kh\u1eed khu\u1ea9n v\u00e0 ti\u1ec7t tr\u00f9ng nh\u1edd ho\u1ea1t t\u00ednh oxy h\u00f3a cao.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hydrogen peroxide (H\u2082O\u2082) l\u00e0 h\u00f3a ch\u1ea5t oxy h\u00f3a v\u1edbi c\u00f4ng th\u1ee9c <\/span><b>H\u2082O\u2082<\/b><span style=\"font-weight: 400;\">. N\u00f3 c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong ph\u00f2ng s\u1ea1ch nh\u01b0ng c\u00f3 t\u1ed1c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng ch\u1eadm h\u01a1n \u0111\u1ed1i v\u1edbi b\u00e0o t\u1eed so v\u1edbi PAA.<\/span><\/p>\n<p><b>T\u1ea1i sao c\u1ea7n ph\u1ed1i h\u1ee3p:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>H\u2082O\u2082 \u0111\u01a1n l\u1ebb<\/b><span style=\"font-weight: 400;\">: di\u1ec7t b\u00e0o t\u1eed nh\u01b0ng ch\u1eadm, c\u1ea7n th\u1eddi gian ti\u1ebfp x\u00fac l\u00e2u (<\/span><b>20-30 ph\u00fat<\/b><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>PAA \u0111\u01a1n l\u1ebb<\/b><span style=\"font-weight: 400;\">: di\u1ec7t b\u00e0o t\u1eed nhanh nh\u01b0ng \u0111\u1ed9c t\u00ednh cao \u1edf n\u1ed3ng \u0111\u1ed9 cao (&gt; <\/span><b>0.5%<\/b><span style=\"font-weight: 400;\">),\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ph\u1ed1i h\u1ee3p PAA + H\u2082O\u2082<\/b><span style=\"font-weight: 400;\">: t\u1ea1o hi\u1ec7u \u1ee9ng c\u1ed9ng h\u01b0\u1edfng v\u1edbi n\u1ed3ng \u0111\u1ed9 PAA th\u1ea5p h\u01a1n (<\/span><b>0.2-0.35%<\/b><span style=\"font-weight: 400;\">), an to\u00e0n h\u01a1n nh\u01b0ng hi\u1ec7u qu\u1ea3 cao<\/span><\/li>\n<\/ul>\n<p><b>Link tham kh\u1ea3o:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/nhathuoclongchau.com.vn\/thanh-phan\/peracetic-acid\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/nhathuoclongchau.com.vn\/thanh-phan\/peracetic-acid<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/alphaagrochem.com\/peracetic-acid-la-gi\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/alphaagrochem.com\/peracetic-acid-la-gi\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Peracetic_acid\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/en.wikipedia.org\/wiki\/Peracetic_acid<\/span><\/a><\/li>\n<\/ul>\n<h2><b>Vai Tr\u00f2 C\u1ee7a H\u2082O\u2082 Trong C\u01a1 Ch\u1ebf Di\u1ec7t B\u00e0o T\u1eed<\/b><\/h2>\n<h3><b>H\u2082O\u2082 t\u1ea1o c\u00e1c g\u1ed1c oxy h\u00f3a m\u1ea1nh (ROS)<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">H\u2082O\u2082 c\u00f3 th\u1ec3 ph\u00e2n h\u1ee7y th\u00e0nh n\u01b0\u1edbc v\u00e0 oxy. Trong s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c ch\u1ea5t x\u00fac t\u00e1c (v\u00ed d\u1ee5 ion kim lo\u1ea1i), H\u2082O\u2082 t\u1ea1o ra c\u00e1c reactive oxygen species (ROS), bao g\u1ed3m g\u1ed1c hydroxyl (\u2022OH). C\u00e1c g\u1ed1c n\u00e0y c\u00f3 ho\u1ea1t t\u00ednh oxy h\u00f3a r\u1ea5t cao, g\u00e2y t\u1ed5n th\u01b0\u01a1ng c\u1ea5u tr\u00fac b\u00e0o t\u1eed th\u00f4ng qua qu\u00e1 tr\u00ecnh oxy h\u00f3a protein, lipid v\u00e0 DNA<\/span><\/p>\n<h3><b>T\u00e1c \u0111\u1ed9ng l\u00ean c\u1ea5u tr\u00fac b\u00e0o t\u1eed<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00e1c ROS l\u00e0m suy y\u1ebfu l\u1edbp v\u1ecf b\u1ea3o v\u1ec7 c\u1ee7a b\u00e0o t\u1eed (spore coat) v\u00e0 l\u1edbp cortex gi\u00e0u peptidoglycan, l\u00e0m gi\u1ea3m t\u00ednh to\u00e0n v\u1eb9n c\u1ea5u tr\u00fac v\u00e0 kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 c\u1ee7a b\u00e0o t\u1eed.<\/span><\/p>\n<h3><b>Vai tr\u00f2 trong t\u00ednh n\u0103ng th\u1ea9m th\u1ea5u<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">S\u1ef1 oxy h\u00f3a b\u1ec1 m\u1eb7t l\u00e0m t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a l\u1edbp v\u1ecf b\u00e0o t\u1eed, t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho c\u00e1c t\u00e1c nh\u00e2n oxy h\u00f3a kh\u00e1c nh\u01b0 peracetic acid (PAA) th\u00e2m nh\u1eadp s\u00e2u h\u01a1n v\u00e0o b\u00ean trong.<\/span><\/p>\n<h3><b>\u00dd ngh\u0129a c\u1ee7a vi\u1ec7c h\u1ed7 tr\u1ee3 nhau<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">H\u2082O\u2082 \u0111\u00f3ng vai tr\u00f2 nh\u01b0 t\u00e1c nh\u00e2n ti\u1ec1n x\u1eed l\u00fd, l\u00e0m suy y\u1ebfu c\u1ea5u tr\u00fac b\u1ea3o v\u1ec7 c\u1ee7a b\u00e0o t\u1eed v\u00e0 t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a PAA trong qu\u00e1 tr\u00ecnh di\u1ec7t b\u00e0o t\u1eed.<\/span><\/p>\n<h2><b>Vai Tr\u00f2 C\u1ee7a PAA Trong C\u01a1 Ch\u1ebf Di\u1ec7t B\u00e0o T\u1eed<\/b><\/h2>\n<h3><b>T\u00e1c \u0111\u1ed9ng l\u00ean m\u00e0ng b\u00ean trong (inner membrane)<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">PAA c\u00f3 kh\u1ea3 n\u0103ng th\u00e2m nh\u1eadp v\u00e0o b\u00ean trong b\u00e0o t\u1eed, nh\u1edd H\u2082O\u2082 \u0111\u00e3 l\u00e0m suy y\u1ebfu c\u1ea5u tr\u00fac b\u1ea3o v\u1ec7 c\u1ee7a b\u00e0o t\u1eed. T\u1ea1i \u0111\u00e2y, PAA oxy h\u00f3a m\u00e0ng b\u00ean trong (inner membrane), l\u00e0m bi\u1ebfn t\u00ednh protein v\u00e0 ph\u00e1 v\u1ee1 c\u1ea5u tr\u00fac lipoprotein. \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn m\u1ea5t t\u00ednh to\u00e0n v\u1eb9n m\u00e0ng v\u00e0 b\u1ea5t ho\u1ea1t c\u00e1c h\u1ec7 enzyme (c\u1ea5u tr\u00fac quan tr\u1ecdng \u0111\u1ec3 vi khu\u1ea9n s\u1ed1ng).<\/span><\/p>\n<h3><b>PAA t\u00e1c \u0111\u1ed9ng l\u00ean DNA &amp; RNA<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">PAA ti\u1ebfp t\u1ee5c oxy h\u00f3a acid nucleic (DNA v\u00e0 RNA), g\u00e2y t\u1ed5n th\u01b0\u01a1ng c\u1ea5u tr\u00fac v\u00e0 \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh sao ch\u00e9p. C\u00e1c t\u1ed5n th\u01b0\u01a1ng n\u00e0y mang t\u00ednh kh\u00f4ng h\u1ed3i ph\u1ee5c, khi\u1ebfn b\u00e0o t\u1eed m\u1ea5t kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n v\u00e0 ho\u1ea1t \u0111\u1ed9ng.<\/span><\/p>\n<h2><b>C\u01a1 Ch\u1ebf C\u1ed9ng H\u01b0\u1edfng Gi\u1eefa PAA + H\u2082O\u2082<\/b><\/h2>\n<h3><b>Kh\u00e1i ni\u1ec7m c\u1ed9ng h\u01b0\u1edfng<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">C\u1ed9ng h\u01b0\u1edfng (synergistic effect) l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng trong \u0111\u00f3 hi\u1ec7u qu\u1ea3 khi k\u1ebft h\u1ee3p hai t\u00e1c nh\u00e2n cao h\u01a1n so v\u1edbi t\u1ed5ng hi\u1ec7u qu\u1ea3 khi s\u1eed d\u1ee5ng ri\u00eang l\u1ebb. \u0110\u1ed1i v\u1edbi PAA v\u00e0 H\u2082O\u2082, s\u1ef1 ph\u1ed1i h\u1ee3p n\u00e0y l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 kh\u1ea3 n\u0103ng di\u1ec7t b\u00e0o t\u1eed.<\/span><\/p>\n<h3><b>C\u01a1 ch\u1ebf c\u1ed9ng h\u01b0\u1edfng PAA + H\u2082O\u2082<\/b><\/h3>\n<h4><b>B\u01b0\u1edbc 1: H\u2082O\u2082 ti\u1ec1n x\u1eed l\u00fd b\u00e0o t\u1eed<\/b><\/h4>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">H\u2082O\u2082 t\u1ea1o ra c\u00e1c reactive oxygen species (ROS), bao g\u1ed3m g\u1ed1c hydroxyl (\u2022OH), th\u00f4ng qua ph\u00e2n h\u1ee7y oxy h\u00f3a c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 x\u00fac t\u00e1c<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00e1c g\u1ed1c n\u00e0y oxy h\u00f3a v\u00e0 l\u00e0m suy y\u1ebfu l\u1edbp v\u1ecf b\u00e0o t\u1eed (spore coat) v\u00e0 l\u1edbp cortex<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u00e0o t\u1eed tr\u1edf n\u00ean y\u1ebfu v\u00e0 m\u1edf h\u01a1n, t\u1ea1o ra c\u00e1c l\u1ed7 nh\u1ecf tr\u00ean b\u1ec1 m\u1eb7t &#8211; l\u00e0m t\u0103ng t\u00ednh th\u1ea9m th\u1ea5u c\u1ee7a c\u1ea5u tr\u00fac b\u1ea3o v\u1ec7<\/span><\/li>\n<\/ul>\n<h4><b>B\u01b0\u1edbc 2: PAA th\u00e2m nh\u1eadp v\u00e0 t\u00e1c \u0111\u1ed9ng n\u1ed9i b\u00e0o<\/b><\/h4>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sau khi l\u1edbp v\u1ecf b\u1ecb suy y\u1ebfu, PAA th\u00e2m nh\u1eadp v\u00e0o b\u00ean trong b\u00e0o t\u1eed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PAA t\u1ea5n c\u00f4ng m\u00e0ng t\u1ebf b\u00e0o b\u00ean trong (cytoplasmic membrane)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PAA c\u0169ng t\u1ea5n c\u00f4ng DNA v\u00e0 RNA &#8211; l\u00e0m bi\u1ebfn t\u00ednh protein v\u00e0 b\u1ea5t ho\u1ea1t c\u00e1c h\u1ec7 enzyme<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peracetic Acid (PAA) g\u00e2y t\u1ed5n th\u01b0\u01a1ng (DNA\/RNA) nh\u1ea7m \u1ee9c ch\u1ebf kh\u1ea3 n\u0103ng sao ch\u00e9p<\/span><\/li>\n<\/ul>\n<h4><b>B\u01b0\u1edbc 3: H\u2082O\u2082 v\u00e0 PAA ho\u1ea1t \u0111\u1ed9ng t\u1eeb ngo\u00e0i v\u00e0o trong<\/b><\/h4>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">H\u2082O\u2082 ti\u1ebfp t\u1ee5c t\u1ea1o ROS t\u00e1c \u0111\u1ed9ng l\u00ean c\u1ea5u tr\u00fac b\u00ean ngo\u00e0i<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">V\u1eeba c\u00f3 PAA \u1edf b\u00ean trong duy tr\u00ec ho\u1ea1t t\u00ednh oxy h\u00f3a l\u00e0m t\u1ed5n th\u01b0\u01a1ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hai c\u01a1 ch\u1ebf tr\u00ean di\u1ec5n ra song song, l\u00e0m t\u0103ng hi\u1ec7u qu\u1ea3 di\u1ec7t b\u00e0o t\u1eed<\/span><\/li>\n<\/ul>\n<h3><b>Hi\u1ec7u qu\u1ea3 c\u1ed9ng h\u01b0\u1edfng<\/b><\/h3>\n<blockquote>\n<ul>\n<li><span style=\"font-weight: 400;\">H\u2082O\u2082 v\u00e0 PAA \u0111\u1ec1u l\u00e0 ch\u1ea5t oxy h\u00f3a v\u1edbi <\/span><b>c\u01a1 ch\u1ebf kh\u00e1c nhau <\/b><span style=\"font-weight: 400;\">nh\u01b0ng l\u1ea1i b\u1ed5 sung cho nhau<\/span><\/li>\n<li><b>H\u2082O\u2082<\/b><span style=\"font-weight: 400;\">: t\u1ea5n c\u00f4ng t\u1eeb ngo\u00e0i, l\u00e0m y\u1ebfu l\u1edbp v\u1ecf<\/span><\/li>\n<li><b>PAA<\/b><span style=\"font-weight: 400;\">: t\u1ea5n c\u00f4ng t\u1eeb trong, b\u1ea5t ho\u1ea1t h\u1ec7 th\u1ed1ng sinh h\u1ecdc<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Khi k\u1ebft h\u1ee3p: <\/span><b>hai h\u01b0\u1edbng t\u1ea5n c\u00f4ng \u0111\u1ed3ng th\u1eddi<\/b><span style=\"font-weight: 400;\">, b\u00e0o t\u1eed s\u1ebd b\u1ecb \u1ee9c ch\u1ebf<\/span><\/li>\n<\/ul>\n<\/blockquote>\n<p><span style=\"font-weight: 400;\">D\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y <\/span><b>PAA + H\u2082O\u2082 c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng b\u00e0o t\u1eed Bacillus t\u1edbi 6-7 log<\/b><span style=\"font-weight: 400;\"> trong th\u1eddi gian ti\u1ebfp x\u00fac <\/span><b>10-15 ph\u00fat<\/b><span style=\"font-weight: 400;\">, trong khi <\/span><b>H\u2082O\u2082 \u0111\u01a1n l\u1ebb c\u1ea7n 20-30 ph\u00fat<\/b><span style=\"font-weight: 400;\"> \u0111\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng.<\/span><\/p>\n<p><b>Link tham kh\u1ea3o:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4751845\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4751845\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/aem.03010-15\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/journals.asm.org\/doi\/10.1128\/aem.03010-15<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1385894725104671\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1385894725104671<\/span><\/a><\/li>\n<\/ul>\n<h2><b>C\u1ed9ng H\u01b0\u1edfng PAA + H\u2082O\u2082 Ki\u1ec3m So\u00e1t Vi Sinh V\u00e0 Bi\u1ebfn Th\u1ec3 Vi Khu\u1ea9n<\/b><\/h2>\n<figure id=\"attachment_9526\" aria-describedby=\"caption-attachment-9526\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-9526\" src=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/3-10.png\" alt=\"cong-huong-paa-h2o2-kiem-soat-vi-sinh-bien-the-vi-khuan\" width=\"600\" height=\"600\" srcset=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/3-10.png 600w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/3-10-300x300.png 300w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/3-10-150x150.png 150w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/3-10-100x100.png 100w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9526\" class=\"wp-caption-text\"><em>C\u1ed9ng H\u01b0\u1edfng PAA + H\u2082O\u2082 Ki\u1ec3m So\u00e1t Vi Sinh V\u00e0 Bi\u1ebfn Th\u1ec3 Vi Khu\u1ea9n<\/em><\/figcaption><\/figure>\n<h3><b>Ki\u1ec3m so\u00e1t vi sinh v\u1eadt<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">S\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa PAA + H\u2082O\u2082 kh\u00f4ng ch\u1ec9 di\u1ec7t b\u00e0o t\u1eed m\u00e0 c\u00f2n <\/span><b>di\u1ec7t vi khu\u1ea9n sinh d\u01b0\u1ee1ng (vegetative cells)<\/b><span style=\"font-weight: 400;\"> m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3. C\u00e1c reactive oxygen species (ROS) t\u1eeb H\u2082O\u2082 t\u1ea5n c\u00f4ng d\u1ec5 d\u00e0ng c\u00e1c vi khu\u1ea9n th\u01b0\u1eddng kh\u00f4ng c\u00f3 v\u1ecf b\u00e0i b\u1ea3o v\u1ec7 d\u00e0y, trong khi PAA b\u1ed5 sung ho\u1ea1t t\u00ednh oxy h\u00f3a m\u1ea1nh, gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 ti\u00eau di\u1ec7t to\u00e0n b\u1ed9 vi sinh.<\/span><\/p>\n<h3><b>H\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng th\u00edch nghi\/kh\u00e1ng h\u00f3a ch\u1ea5t<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Vi\u1ec7c s\u1eed d\u1ee5ng m\u1ed9t h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n \u0111\u01a1n l\u1ebb trong th\u1eddi gian d\u00e0i c\u00f3 th\u1ec3 t\u1ea1o \u00e1p l\u1ef1c ch\u1ecdn l\u1ecdc, d\u1eabn \u0111\u1ebfn kh\u1ea3 n\u0103ng th\u00edch nghi c\u1ee7a vi sinh v\u1eadt (v\u00ed d\u1ee5 t\u0103ng bi\u1ec3u hi\u1ec7n enzyme nh\u01b0 catalase).<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u00f9ng H\u2082O\u2082 6% li\u00ean t\u1ee5c, l\u00e2u d\u1ea7n Bacillus c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c <\/span><b>enzyme nh\u01b0 catalase<\/b><span style=\"font-weight: 400;\"> \u0111\u1ec3 b\u1ea3o v\u1ec7 b\u1ea3n th\u00e2n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nh\u01b0ng khi ph\u1ed1i h\u1ee3p <\/span><b>PAA + H\u2082O\u2082, c\u01a1 ch\u1ebf t\u1ea5n c\u00f4ng l\u00e0 \u0111a chi\u1ec1u<\/b><span style=\"font-weight: 400;\"> (t\u1eeb trong l\u1eabn ngo\u00e0i)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vi khu\u1ea9n kh\u00f3 ph\u00e1t tri\u1ec3n kh\u00e1ng t\u00ednh v\u00ec <\/span><b>ph\u1ea3i v\u01b0\u1ee3t qua hai c\u01a1 ch\u1ebf kh\u00e1c nhau c\u00f9ng l\u00fac<\/b><span style=\"font-weight: 400;\">, \u0111i\u1ec1u n\u00e0y y\u00eau c\u1ea7u \u0111\u1ed9t bi\u1ebfn multiple m\u00e0 x\u00e1c su\u1ea5t r\u1ea5t th\u1ea5p<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lu\u00e2n phi\u00ean PAA + H\u2082O\u2082 v\u1edbi H\u2082O\u2082 6% \u0111\u01a1n<\/b><span style=\"font-weight: 400;\">: gi\u00fap tr\u00e1nh t\u00edch l\u0169y kh\u00e1ng t\u00ednh b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i \u00e1p l\u1ef1c ch\u1ecdn l\u1ecdc<\/span><\/li>\n<\/ul>\n<h3><b>\u0110a D\u1ea1ng Chi\u1ebfn L\u01b0\u1ee3c Kh\u1eed Khu\u1ea9n<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">C\u1ed9ng h\u01b0\u1edfng PAA + H\u2082O\u2082 cho ph\u00e9p lu\u00e2n phi\u00ean t\u1ed1t trong ch\u01b0\u01a1ng tr\u00ecnh kh\u1eed khu\u1ea9n:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tu\u1ea7n 1-2<\/b><span style=\"font-weight: 400;\">: d\u00f9ng PAA + H\u2082O\u2082 (Sporicide m\u1ea1nh)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tu\u1ea7n 3-4<\/b><span style=\"font-weight: 400;\">: d\u00f9ng H\u2082O\u2082 <\/span><b>6%<\/b><span style=\"font-weight: 400;\"> (Sporicide v\u1eeba ph\u1ea3i)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y gi\u00fap duy tr\u00ec hi\u1ec7u qu\u1ea3 kh\u1eed khu\u1ea9n v\u00e0 h\u1ea1n ch\u1ebf nguy c\u01a1 th\u00edch nghi c\u1ee7a vi sinh v\u1eadt trong m\u00f4i tr\u01b0\u1eddng GMP.<\/span><\/p>\n<p><b>Link tham kh\u1ea3o:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/sepro.vn\/dos-donts-phong-sach-gmp-eu-annex-1\/\"><b>https:\/\/sepro.vn\/dos-donts-phong-sach-gmp-eu-annex-1\/<\/b><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4751845\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4751845\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/aem.03010-15\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/journals.asm.org\/doi\/10.1128\/aem.03010-15<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-76036-2\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.nature.com\/articles\/s41598-024-76036-2<\/span><\/a><\/li>\n<\/ul>\n<h2><b>\u0110\u1ed9 An To\u00e0n C\u1ee7a PAA &amp; H\u2082O\u2082 Cho Nh\u00e2n Vi\u00ean K\u1ef9 Thu\u1eadt<\/b><\/h2>\n<h3><b>So s\u00e1nh v\u1edbi PAA \u0111\u01a1n l\u1ebb<\/b><\/h3>\n<p><b>PAA \u0111\u01a1n l\u1ebb n\u1ed3ng \u0111\u1ed9 cao<\/b><span style=\"font-weight: 400;\"> (&gt; <\/span><b>0.5%<\/b><span style=\"font-weight: 400;\">) c\u00f3 \u0111\u1ed9c t\u00ednh cao, c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng da, ni\u00eam m\u1ea1c m\u1eaft, v\u00e0 h\u00f4 h\u1ea5p theo h\u01b0\u1edbng d\u1eabn an to\u00e0n lao \u0111\u1ed9ng. Khi s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p PAA + H\u2082O\u2082, n\u1ed3ng \u0111\u1ed9 PAA th\u01b0\u1eddng \u0111\u01b0\u1ee3c duy tr\u00ec \u1edf m\u1ee9c th\u1ea5p h\u01a1n (0,2\u20130,35%), trong khi H\u2082O\u2082 \u0111\u00f3ng vai tr\u00f2 b\u1ed5 sung ho\u1ea1t t\u00ednh oxy h\u00f3a.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y \u0111em l\u1ea1i \u0111\u1ed9 an to\u00e0n cao h\u01a1n cho nh\u00e2n vi\u00ean, \u0111\u1ed9c t\u00ednh th\u1ea5p h\u01a1n, gi\u1ea3m nguy c\u01a1 k\u00edch \u1ee9ng. Contact time ng\u1eafn (10-15 ph\u00fat) gi\u00fap gi\u1ea3m th\u1eddi gian ti\u1ebfp x\u00fac h\u00f3a ch\u1ea5t so v\u1edbi H\u2082O\u2082 \u0111\u01a1n l\u1ebb (20-30 ph\u00fat).<\/span><\/p>\n<h3><b>Kh\u00f4ng \u0110\u1ec3 L\u1ea1i T\u1ed3n D\u01b0 \u0110\u1ed9c H\u1ea1i<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">C\u1ea3 <\/span><b>PAA v\u00e0 H\u2082O\u2082 \u0111\u1ec1u oxy h\u00f3a v\u00e0 ph\u00e2n h\u1ee7y th\u00e0nh n\u01b0\u1edbc v\u00e0 oxy<\/b><span style=\"font-weight: 400;\"> theo c\u00e1c nghi\u00ean c\u1ee9u t\u00e0i li\u1ec7u an to\u00e0n. Kh\u00f4ng c\u00f3 t\u1ed3n d\u01b0 h\u00f3a ch\u1ea5t nguy hi\u1ec3m cho nh\u00e2n vi\u00ean ho\u1eb7c s\u1ea3n ph\u1ea9m d\u01b0\u1ee3c ph\u1ea9m. <\/span><b>Kh\u00f4ng c\u1ea7n r\u1eeda l\u1ea1i b\u1ec1 m\u1eb7t sau kh\u1eed khu\u1ea9n<\/b><span style=\"font-weight: 400;\"> (v\u1edbi s\u1ea3n ph\u1ea9m nh\u01b0 <a href=\"https:\/\/sepro.vn\/product\/qt-sporicide\/\"><strong>QT Sporicide<\/strong><\/a>). Gi\u1ea3m th\u1eddi gian l\u00e0m vi\u1ec7c, h\u1ea1n ch\u1ebf ti\u1ebfp x\u00fac v\u1edbi h\u00f3a ch\u1ea5t.<\/span><\/p>\n<h3><b>Ki\u1ec3m So\u00e1t N\u1ed3ng \u0110\u1ed9 V\u00e0 Ti\u1ebfp X\u00fac<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">S\u1ea3n ph\u1ea9m <\/span><b>PAA + H\u2082O\u2082 \u0111\u01b0\u1ee3c chu\u1ea9n h\u00f3a n\u1ed3ng \u0111\u1ed9 s\u1eb5n<\/b><span style=\"font-weight: 400;\"> (v\u00ed d\u1ee5 QT Sporicide). <\/span><b>Kh\u00f4ng c\u1ea7n nh\u00e2n vi\u00ean ph\u1ea3i pha lo\u00e3ng hay \u0111i\u1ec1u ch\u1ec9nh n\u1ed3ng \u0111\u1ed9<\/b><span style=\"font-weight: 400;\"> (gi\u1ea3m r\u1ee7i ro ti\u1ebfp x\u00fac cao). <\/span><b>Contact time x\u00e1c \u0111\u1ecbnh r\u00f5 (10-15 ph\u00fat)<\/b><span style=\"font-weight: 400;\"> gi\u00fap ki\u1ec3m so\u00e1t ti\u1ebfp x\u00fac theo h\u01b0\u1edbng d\u1eabn an to\u00e0n lao \u0111\u1ed9ng. Ghi ch\u00e9p chi ti\u1ebft gi\u00fap theo d\u00f5i an to\u00e0n lao \u0111\u1ed9ng v\u00e0 tu\u00e2n th\u1ee7 quy \u0111\u1ecbnh.<\/span><\/p>\n<p><b>Link tham kh\u1ea3o:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/multimedia.3m.com\/mws\/media\/2009476O\/worker-personal-protective-equipment-ppe-tips-for-peracetic-acid-use-in-pharma-manu\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/multimedia.3m.com\/mws\/media\/2009476O\/worker-personal-protective-equipment-ppe-tips-for-peracetic-acid-use-in-pharma-manu<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/oshainfo.gatech.edu\/wp-content\/uploads\/2023\/05\/paa-safety-and-health-guidelines-final.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/oshainfo.gatech.edu\/wp-content\/uploads\/2023\/05\/paa-safety-and-health-guidelines-final.pdf<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/vietchem.com.vn\/tin-tuc\/peracetic-acid.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/vietchem.com.vn\/tin-tuc\/peracetic-acid.html<\/span><\/a><\/li>\n<\/ul>\n<h2><b>\u1ee8ng D\u1ee5ng PAA + H\u2082O\u2082 Trong Ph\u00f2ng S\u1ea1ch GMP<\/b><\/h2>\n<figure id=\"attachment_9530\" aria-describedby=\"caption-attachment-9530\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-9530\" src=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/4-8.png\" alt=\"ung-dung-paa-h2o2-trong-phong-sach-gmp\" width=\"600\" height=\"600\" srcset=\"https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/4-8.png 600w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/4-8-300x300.png 300w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/4-8-150x150.png 150w, https:\/\/sepro.vn\/wp-content\/uploads\/2026\/03\/4-8-100x100.png 100w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9530\" class=\"wp-caption-text\"><em>\u1ee8ng D\u1ee5ng PAA + H\u2082O\u2082 Trong Ph\u00f2ng S\u1ea1ch GMP<\/em><\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">S\u1ea3n ph\u1ea9m <\/span><b>QT Sporicide<\/b><span style=\"font-weight: 400;\"> ch\u1ee9a PAA + H\u2082O\u2082 l\u00e0 v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Contact time<\/b><span style=\"font-weight: 400;\">: <\/span><b>10-15 ph\u00fat<\/b><span style=\"font-weight: 400;\"> (ng\u1eafn h\u01a1n H\u2082O\u2082 \u0111\u01a1n l\u1ebb c\u1ea7n <\/span><b>20-30 ph\u00fat<\/b><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>N\u1ed3ng \u0111\u1ed9<\/b><span style=\"font-weight: 400;\">: <\/span><b>PAA 0.2-0.35% + H\u2082O\u2082 5.9-23.6%<\/b><span style=\"font-weight: 400;\"> (theo CDC, c\u1ed9ng h\u01b0\u1edfng t\u1ed1t nh\u1ea5t \u1edf n\u1ed3ng \u0111\u1ed9 n\u00e0y)<\/span><\/li>\n<\/ul>\n<p><b>\u1ee8ng d\u1ee5ng:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kh\u1eed khu\u1ea9n \u0111\u1ecbnh k\u1ef3 trong ph\u00f2ng s\u1ea1ch Grade A, B<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lu\u00e2n phi\u00ean v\u1edbi H\u2082O\u2082 <\/span><b>6%<\/b><span style=\"font-weight: 400;\"> \u0111\u1ec3 tr\u00e1nh kh\u00e1ng t\u00ednh<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hi\u1ec7u qu\u1ea3 cao, contact time ng\u1eafn = \u00edt gi\u00e1n \u0111o\u1ea1n s\u1ea3n xu\u1ea5t<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Xem th\u00eam: <\/span><a href=\"https:\/\/sepro.vn\/hoa-chat-khu-khuan-phong-sach-theo-gmp-eu\/\"><b>H\u00f3a Ch\u1ea5t Kh\u1eed Khu\u1ea9n Ph\u00f2ng S\u1ea1ch Theo GMP EU<\/b><\/a><\/p>\n<h2><b>PAA + H\u2082O\u2082 C\u00f3 T\u1ea1o Ra Ch\u1ea5t M\u1edbi?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">C\u00e2u h\u1ecfi ph\u1ed5 bi\u1ebfn: Khi PAA + H\u2082O\u2082 k\u1ebft h\u1ee3p, c\u00f3 x\u1ea3y ra ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc t\u1ea1o ra ch\u1ea5t m\u1edbi m\u1ea1nh h\u01a1n kh\u00f4ng?<\/span><\/p>\n<p><b>Tr\u1ea3 l\u1eddi:<\/b><span style=\"font-weight: 400;\"><strong> Kh\u00f4ng ch\u00ednh x\u00e1c nh\u01b0 v\u1eady<\/strong>. Theo c\u00e1c t\u00e0i li\u1ec7u khoa h\u1ecdc, <\/span><b>PAA + H\u2082O\u2082 kh\u00f4ng t\u1ea1o ra m\u1ed9t ch\u1ea5t m\u1edbi ho\u00e0n to\u00e0n kh\u00e1c<\/b><span style=\"font-weight: 400;\">. C\u1ee5 th\u1ec3 h\u01a1n:\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">PAA v\u00e0 H\u2082O\u2082 khi ph\u1ed1i h\u1ee3p kh\u00f4ng t\u1ea1o ra m\u1ed9t ho\u1ea1t ch\u1ea5t m\u1edbi ri\u00eang bi\u1ec7t. Trong h\u1ec7 n\u00e0y, peracetic acid (PAA, CH\u2083CO\u2083H) v\u00e0 H\u2082O\u2082 v\u1eabn gi\u1eef nguy\u00ean b\u1ea3n ch\u1ea5t h\u00f3a h\u1ecdc ban \u0111\u1ea7u. Hi\u1ec7u qu\u1ea3 t\u0103ng l\u00ean l\u00e0 do s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai t\u00e1c nh\u00e2n oxy h\u00f3a, kh\u00f4ng ph\u1ea3i do h\u00ecnh th\u00e0nh m\u1ed9t h\u1ee3p ch\u1ea5t m\u1edbi.<\/span><\/p>\n<p><b>C\u01a1 Ch\u1ebf T\u01b0\u01a1ng T\u00e1c<\/b><\/p>\n<p><span style=\"font-weight: 400;\">D\u1ef1a tr\u00ean c\u00e1c nghi\u00ean c\u1ee9u:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>H\u2082O\u2082 <\/b><span style=\"font-weight: 400;\">c\u00f3 th\u1ec3 t\u1ea1o ra c\u00e1c reactive oxygen species (ROS), bao g\u1ed3m g\u1ed1c hydroxyl (\u2022OH)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00e1c ROS n\u00e0y g\u00f3p ph\u1ea7n t\u0103ng c\u01b0\u1eddng m\u00f4i tr\u01b0\u1eddng oxy h\u00f3a v\u00e0 h\u1ed7 tr\u1ee3 ho\u1ea1t t\u00ednh c\u1ee7a PAA<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PAA ti\u1ebfp t\u1ee5c \u0111\u00f3ng vai tr\u00f2 t\u00e1c nh\u00e2n oxy h\u00f3a m\u1ea1nh, t\u1ea1o ra nhi\u1ec1u g\u1ed1c peracetyl (<\/span><b>CH\u2083CO\u2083\u00b7<\/b><span style=\"font-weight: 400;\">) t\u00e1c \u0111\u1ed9ng l\u00ean m\u00e0ng v\u00e0 th\u00e0nh ph\u1ea7n n\u1ed9i b\u00e0o c\u1ee7a vi sinh v\u1eadt<\/span><\/li>\n<\/ul>\n<p><b>K\u1ebft lu\u1eadn:<\/b><span style=\"font-weight: 400;\"> PAA + H\u2082O\u2082 l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p hi\u1ec7u qu\u1ea3 d\u1ef1a tr\u00ean t\u01b0\u01a1ng t\u00e1c v\u1eadt l\u00fd-h\u00f3a h\u1ecdc, kh\u00f4ng ph\u1ea3i ph\u1ea3n \u1ee9ng t\u1ea1o ch\u1ea5t m\u1edbi.<\/span><\/p>\n<p><b>Link tham kh\u1ea3o:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Peracetic_acid\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/en.wikipedia.org\/wiki\/Peracetic_acid<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9022431\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9022431\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/scielo.org.za\/pdf\/wsa\/v40n1\/17.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/scielo.org.za\/pdf\/wsa\/v40n1\/17.pdf<\/span><\/a><\/li>\n<\/ul>\n<h2><b>So S\u00e1nh: PAA + H\u2082O\u2082 vs H\u2082O\u2082 \u0110\u01a1n L\u1ebb vs PAA \u0110\u01a1n L\u1ebb<\/b><\/h2>\n<table>\n<tbody>\n<tr>\n<td><b>Ti\u00eau Ch\u00ed<\/b><\/td>\n<td><b>H\u2082O\u2082 \u0110\u01a1n L\u1ebb 6%<\/b><\/td>\n<td><b>PAA \u0110\u01a1n L\u1ebb<\/b><\/td>\n<td><b>PAA + H\u2082O\u2082<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Contact Time<\/b><\/td>\n<td><b>20-30 ph\u00fat<\/b><\/td>\n<td><b>10-15 ph\u00fat<\/b><\/td>\n<td><b>10-15 ph\u00fat<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>N\u1ed3ng \u0111\u1ed9 Hi\u1ec7u Qu\u1ea3<\/b><\/td>\n<td><b>6-7.5%<\/b><\/td>\n<td><b>0.3-0.5%<\/b><\/td>\n<td><b>PAA 0.2-0.35% + H\u2082O\u2082 5.9-23.6%<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Di\u1ec7t B\u00e0o T\u1eed<\/b><\/td>\n<td><span style=\"font-weight: 400;\">C\u00f3<\/span><\/td>\n<td><span style=\"font-weight: 400;\">C\u00f3<\/span><\/td>\n<td><b>C\u00f3 (m\u1ea1nh nh\u1ea5t)<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>\u0110\u1ed9c T\u00ednh<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Trung b\u00ecnh<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>C\u1ed9ng H\u01b0\u1edfng<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Kh\u00f4ng<\/span><\/td>\n<td><b>C\u00f3<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>An To\u00e0n Nh\u00e2n Vi\u00ean<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p<\/span><\/td>\n<td><b>Cao<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>T\u00ednh \u1ed4n \u0110\u1ecbnh<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Cao<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Th\u1ea5p<\/span><\/td>\n<td><b>Cao<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>Link tham kh\u1ea3o:<\/b> <a href=\"https:\/\/www.cdc.gov\/infectioncontrol\/pdf\/guidelines\/disinfection-guidelines.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.cdc.gov\/infectioncontrol\/pdf\/guidelines\/disinfection-guidelines.pdf<\/span><\/a><\/p>\n<h2><b>Nh\u1eefng C\u00e2u H\u1ecfi Th\u01b0\u1eddng G\u1eb7p &#8211; <\/b><strong data-start=\"572\" data-end=\"609\">C\u01a1 ch\u1ebf di\u1ec7t b\u00e0o t\u1eed c\u1ee7a PAA + H2O2<\/strong><\/h2>\n<blockquote>\n<h3><b>T\u1ea1i Sao PAA + H\u2082O\u2082 Hi\u1ec7u Qu\u1ea3 H\u01a1n H\u2082O\u2082 6% \u0110\u01a1n L\u1ebb<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">V\u00ec <\/span><b>PAA + H\u2082O\u2082 t\u1ea1o ra c\u1ed9ng h\u01b0\u1edfng<\/b><span style=\"font-weight: 400;\">, H\u2082O\u2082 l\u00e0m y\u1ebfu l\u1edbp v\u1ecf b\u00e0o t\u1eed, PAA th\u00e2m nh\u1eadp v\u00e0o trong v\u00e0 ph\u00e1 v\u1ee1 DNA. <\/span><b>K\u1ebft qu\u1ea3: contact time ng\u1eafn h\u01a1n 50%<\/b><span style=\"font-weight: 400;\"> (<\/span><b>10-15 ph\u00fat<\/b><span style=\"font-weight: 400;\"> vs <\/span><b>20-30 ph\u00fat<\/b><span style=\"font-weight: 400;\">) nh\u01b0ng hi\u1ec7u qu\u1ea3 cao h\u01a1n.<\/span><\/p>\n<h3><b>C\u00f3 C\u1ea7n D\u00f9ng PAA + H\u2082O\u2082 Li\u00ean T\u1ee5c Kh\u00f4ng, Hay C\u00f3 Th\u1ec3 Lu\u00e2n Phi\u00ean V\u1edbi H\u2082O\u2082 6%<\/b><\/h3>\n<p><b>N\u00ean lu\u00e2n phi\u00ean<\/b><span style=\"font-weight: 400;\">. V\u00ec d\u00f9ng c\u00f9ng m\u1ed9t h\u00f3a ch\u1ea5t l\u00e2u, vi khu\u1ea9n c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n kh\u00e1ng t\u00ednh. <\/span><b>Lu\u00e2n phi\u00ean PAA + H\u2082O\u2082 v\u1edbi H\u2082O\u2082 6%<\/b><span style=\"font-weight: 400;\"> gi\u00fap tr\u00e1nh kh\u00e1ng t\u00ednh v\u00e0 duy tr\u00ec hi\u1ec7u qu\u1ea3 l\u00e2u d\u00e0i.<\/span><\/p>\n<h3><b>PAA + H\u2082O\u2082 C\u00f3 \u0110\u1ec3 L\u1ea1i T\u1ed3n D\u01b0 \u0110\u1ed9c H\u1ea1i Kh\u00f4ng ?<\/b><\/h3>\n<p><b>Kh\u00f4ng<\/b><span style=\"font-weight: 400;\">. C\u1ea3 PAA v\u00e0 H\u2082O\u2082 \u0111\u1ec1u oxy h\u00f3a v\u00e0 ph\u00e2n h\u1ee7y th\u00e0nh n\u01b0\u1edbc v\u00e0 oxy. Kh\u00f4ng c\u00f3 t\u1ed3n d\u01b0 nguy hi\u1ec3m.<\/span><\/p>\n<h3><b>S\u1ea3n Ph\u1ea9m N\u00e0o Ch\u1ee9a PAA + H\u2082O\u2082<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">V\u00ed d\u1ee5: <\/span><b>QT Sporicide<\/b><span style=\"font-weight: 400;\"> (peracetic acid + hydrogen peroxide), <\/span><b>STERIS Spor-Klenz<\/b><span style=\"font-weight: 400;\">, <\/span><b>Contec PeridoxRTU<\/b><span style=\"font-weight: 400;\">, <\/span><b>VAI\/Veltek DECON-SPORE 200 Plus<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><b>PAA + H\u2082O\u2082 C\u00f3 Ph\u00f9 H\u1ee3p Cho Grade A (V\u00f4 Tr\u00f9ng) Kh\u00f4ng ?<\/b><\/h3>\n<p><b>C\u00f3, ho\u00e0n to\u00e0n ph\u00f9 h\u1ee3p<\/b><span style=\"font-weight: 400;\">. <\/span><b>Contact time ng\u1eafn (10-15 ph\u00fat)<\/b><span style=\"font-weight: 400;\"> kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00ednh v\u00f4 tr\u00f9ng c\u1ee7a kh\u00f4ng kh\u00ed. Th\u1ef1c t\u1ebf, Grade A th\u01b0\u1eddng d\u00f9ng <\/span><b>PAA + H\u2082O\u2082<\/b><span style=\"font-weight: 400;\"> v\u00ec hi\u1ec7u qu\u1ea3 cao v\u00e0 gi\u00e1n \u0111o\u1ea1n \u00edt.<\/span><\/p><\/blockquote>\n<h2><b>K\u1ebft Lu\u1eadn<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf c\u1ed9ng h\u01b0\u1edfng gi\u1eefa <\/span><b>PAA + H\u2082O\u2082<\/b><span style=\"font-weight: 400;\"> l\u00e0 m\u1ed9t trong nh\u1eefng ph\u00e1t hi\u1ec7n quan tr\u1ecdng nh\u1ea5t trong kh\u1eed khu\u1ea9n ph\u00f2ng s\u1ea1ch. Thay v\u00ec d\u00f9ng m\u1ed9t h\u00f3a ch\u1ea5t \u0111\u01a1n l\u1ebb, s\u1ef1 k\u1ebft h\u1ee3p <\/span><b>PAA + H\u2082O\u2082<\/b><span style=\"font-weight: 400;\"> t\u1ea1o ra m\u1ed9t s\u1ee9c m\u1ea1nh l\u1edbn h\u01a1n: <\/span><b>H\u2082O\u2082 ti\u1ec1n x\u1eed l\u00fd b\u00e0o t\u1eed<\/b><span style=\"font-weight: 400;\"> (l\u00e0m y\u1ebfu l\u1edbp v\u1ecf), trong khi <\/span><b>PAA th\u00e2m nh\u1eadp v\u00e0 ph\u00e1 v\u1ee1 c\u1ea5u tr\u00fac s\u1ed1ng<\/b><span style=\"font-weight: 400;\"> t\u1eeb b\u00ean trong.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">S\u1ef1 c\u1ed9ng h\u01b0\u1edfng n\u00e0y kh\u00f4ng ch\u1ec9 hi\u1ec7u qu\u1ea3 m\u00e0 c\u00f2n l\u00e0 <\/span><b>gi\u1ea3i ph\u00e1p an to\u00e0n cho c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c<\/b><span style=\"font-weight: 400;\"> v\u00ec n\u1ed3ng \u0111\u1ed9 PAA th\u1ea5p h\u01a1n (<\/span><b>0.2-0.35%<\/b><span style=\"font-weight: 400;\"> thay v\u00ec <\/span><b>0.5%<\/b><span style=\"font-weight: 400;\"> tr\u1edf l\u00ean), <\/span><b>kh\u00f4ng \u0111\u1ec3 l\u1ea1i t\u1ed3n d\u01b0 h\u00f3a ch\u1ea5t \u0111\u1ed9c h\u1ea1i<\/b><span style=\"font-weight: 400;\">, <\/span><b>contact time ng\u1eafn (10-15 ph\u00fat)<\/b><span style=\"font-weight: 400;\"> gi\u00fap nh\u00e2n vi\u00ean \u00edt ti\u1ebfp x\u00fac h\u00f3a ch\u1ea5t. Ngo\u00e0i ra, <\/span><b>kh\u1ea3 n\u0103ng lu\u00e2n phi\u00ean v\u1edbi H\u2082O\u2082 6%<\/b><span style=\"font-weight: 400;\"> gi\u00fap ki\u1ec3m so\u00e1t vi sinh to\u00e0n di\u1ec7n, <\/span><b>tr\u00e1nh bi\u1ebfn th\u1ec3 vi khu\u1ea9n kh\u00e1ng t\u00ednh<\/b><span style=\"font-weight: 400;\">, duy tr\u00ec hi\u1ec7u qu\u1ea3 l\u00e2u d\u00e0i.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Khi s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m <\/span><b>PAA + H\u2082O\u2082 nh\u01b0 QT Sporicide<\/b><span style=\"font-weight: 400;\">, c\u00e1c nh\u00e0 m\u00e1y d\u01b0\u1ee3c kh\u00f4ng ch\u1ec9 nh\u1eadn \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 cao m\u00e0 c\u00f2n s\u1ef1 y\u00ean t\u00e2m v\u1ec1 an to\u00e0n lao \u0111\u1ed9ng v\u00e0 hi\u1ec7u qu\u1ea3 b\u1ec1n v\u1eefng. <\/span><b>K\u1ebft h\u1ee3p v\u1edbi lu\u00e2n phi\u00ean H\u2082O\u2082 6%<\/b><span style=\"font-weight: 400;\">, c\u00e1c nh\u00e0 m\u00e1y c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t b\u00e0o t\u1eed hi\u1ec7u qu\u1ea3, tr\u00e1nh kh\u00e1ng t\u00ednh, ki\u1ec3m so\u00e1t bi\u1ebfn th\u1ec3 vi khu\u1ea9n, v\u00e0 tu\u00e2n th\u1ee7 ti\u00eau chu\u1ea9n GMP m\u1ed9t c\u00e1ch to\u00e0n di\u1ec7n. <\/span><b>\u0110\u00f3 l\u00e0 l\u00fd do t\u1ea1i sao PAA + H\u2082O\u2082 l\u00e0 gi\u1ea3i ph\u00e1p an to\u00e0n, hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u00e1ng tin c\u1eady cho c\u00e1c ph\u00f2ng s\u1ea1ch hi\u1ec7n \u0111\u1ea1i.<\/b><\/p>\n<p><b>Link tham kh\u1ea3o ch\u00ednh:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4751845\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4751845\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/aem.03010-15\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/journals.asm.org\/doi\/10.1128\/aem.03010-15<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.cdc.gov\/infectioncontrol\/pdf\/guidelines\/disinfection-guidelines.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.cdc.gov\/infectioncontrol\/pdf\/guidelines\/disinfection-guidelines.pdf<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/oshainfo.gatech.edu\/wp-content\/uploads\/2023\/05\/paa-safety-and-health-guidelines-final.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/oshainfo.gatech.edu\/wp-content\/uploads\/2023\/05\/paa-safety-and-health-guidelines-final.pdf<\/span><\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Vi\u1ec7c ki\u1ec3m so\u00e1t b\u00e0o t\u1eed vi khu\u1ea9n l\u00e0 y\u00eau c\u1ea7u b\u1eaft bu\u1ed9c trong nh\u00e0 m\u00e1y d\u01b0\u1ee3c GMP. Tuy nhi\u00ean, n\u1ebfu ch\u1ec9 d\u00f9ng hydrogen peroxide (H\u2082O\u2082) ho\u1eb7c peracetic acid (PAA) c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1ea1t hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 ch\u1ee7ng vi khu\u1ea9n sinh b\u00e0o t\u1eed c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng h\u00f3a ch\u1ea5t cao. Do \u0111\u00f3, s\u1ef1 &hellip; <a href=\"https:\/\/sepro.vn\/vi\/co-che-diet-bao-tu-cua-paa-h2o2-trong-phong-sach-gmp\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">C\u01a1 ch\u1ebf di\u1ec7t b\u00e0o t\u1eed c\u1ee7a PAA + H2O2 Trong Ph\u00f2ng S\u1ea1ch GMP<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":9532,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[126],"tags":[],"class_list":["post-9515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"_links":{"self":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts\/9515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/comments?post=9515"}],"version-history":[{"count":3,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts\/9515\/revisions"}],"predecessor-version":[{"id":9534,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/posts\/9515\/revisions\/9534"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/media\/9532"}],"wp:attachment":[{"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/media?parent=9515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/categories?post=9515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sepro.vn\/vi\/wp-json\/wp\/v2\/tags?post=9515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}