{"id":13953,"date":"2026-08-24T23:07:58","date_gmt":"2026-08-24T16:07:58","guid":{"rendered":"https:\/\/sepro.vn\/?p=13953"},"modified":"2026-08-24T23:07:58","modified_gmt":"2026-08-24T16:07:58","slug":"ung-dung-nuoc-di-phong-sach","status":"publish","type":"post","link":"https:\/\/sepro.vn\/vi\/ung-dung-nuoc-di-phong-sach\/","title":{"rendered":"\u1ee8ng D\u1ee5ng N\u01b0\u1edbc DI Trong V\u1ec7 Sinh Ph\u00f2ng S\u1ea1ch: Vai Tr\u00f2 Th\u1ef1c T\u1ebf"},"content":{"rendered":"

N\u01b0\u1edbc DI \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong v\u1ec7 sinh ph\u00f2ng s\u1ea1ch \u0111\u1ec3 pha h\u00f3a ch\u1ea5t, l\u00e0m \u01b0\u1edbt d\u1ee5ng c\u1ee5 v\u00e0 tr\u00e1ng r\u1eeda thi\u1ebft b\u1ecb. Tuy nhi\u00ean, n\u01b0\u1edbc DI kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng kh\u1eed khu\u1ea9n v\u00e0 v\u1eabn c\u00f3 nguy c\u01a1 nhi\u1ec5m vi sinh n\u1ebfu h\u1ec7 th\u1ed1ng kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t \u0111\u00fang c\u00e1ch. V\u1eady \u1ee9ng d\u1ee5ng n\u01b0\u1edbc DI trong ph\u00f2ng s\u1ea1ch GMP nh\u01b0 th\u1ebf n\u00e0o v\u00e0 c\u1ea7n l\u01b0u \u00fd g\u00ec khi s\u1eed d\u1ee5ng?<\/span><\/p>\n

N\u01b0\u1edbc DI l\u00e0 g\u00ec v\u00e0 c\u00f3 vai tr\u00f2 g\u00ec trong v\u1ec7 sinh ph\u00f2ng s\u1ea1ch?<\/b><\/span><\/h3>\n

N\u01b0\u1edbc DI l\u00e0 g\u00ec?<\/b><\/h3>\n

N\u01b0\u1edbc DI l\u00e0 vi\u1ebft t\u1eaft c\u1ee7a <\/span>Deionized Water<\/b>, hay n\u01b0\u1edbc kh\u1eed ion. \u0110\u00e2y l\u00e0 lo\u1ea1i n\u01b0\u1edbc \u0111\u01b0\u1ee3c x\u1eed l\u00fd th\u00f4ng qua <\/span>nh\u1ef1a trao \u0111\u1ed5i ion (ion exchange resin)<\/b> nh\u1eb1m lo\u1ea1i b\u1ecf ph\u1ea7n l\u1edbn c\u00e1c cation v\u00e0 anion h\u00f2a tan trong n\u01b0\u1edbc.<\/span><\/p>\n

M\u1ed9t trong nh\u1eefng th\u00f4ng s\u1ed1 th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc DI l\u00e0 <\/span>\u0111\u1ed9 d\u1eabn \u0111i\u1ec7n (conductivity)<\/b>, th\u01b0\u1eddng \u0111\u01b0\u1ee3c bi\u1ec3u th\u1ecb b\u1eb1ng \u00b5S\/cm.<\/span><\/p>\n

Kh\u00e1c v\u1edbi <\/span>n\u01b0\u1edbc RO (Reverse Osmosis)<\/b>, s\u1eed d\u1ee5ng m\u00e0ng b\u00e1n th\u1ea5m v\u00e0 \u00e1p l\u1ef1c \u0111\u1ec3 lo\u1ea1i b\u1ecf nhi\u1ec1u lo\u1ea1i t\u1ea1p ch\u1ea5t, qu\u00e1 tr\u00ecnh DI t\u1eadp trung ch\u1ee7 y\u1ebfu v\u00e0o vi\u1ec7c lo\u1ea1i b\u1ecf ion h\u00f2a tan.<\/span><\/p>\n

Do \u0111\u00f3, n\u01b0\u1edbc DI c\u00f3 \u0111\u1ed9 d\u1eabn \u0111i\u1ec7n th\u1ea5p nh\u01b0ng \u0111i\u1ec1u n\u00e0y <\/span>kh\u00f4ng \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c n\u01b0\u1edbc \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ho\u00e0n to\u00e0n v\u1ec1 m\u1eb7t vi sinh<\/b>.<\/span><\/p>\n

N\u01b0\u1edbc DI v\u1eabn c\u00f3 th\u1ec3 ch\u1ee9a vi sinh v\u1eadt, ch\u1ea5t h\u1eefu c\u01a1 h\u00f2a tan ho\u1eb7c n\u1ed9i \u0111\u1ed9c t\u1ed1 n\u1ebfu h\u1ec7 th\u1ed1ng kh\u00f4ng c\u00f3 c\u00e1c b\u01b0\u1edbc x\u1eed l\u00fd v\u00e0 ki\u1ec3m so\u00e1t b\u1ed5 sung nh\u01b0 UV, l\u1ecdc tinh ho\u1eb7c c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ph\u00f9 h\u1ee3p kh\u00e1c.<\/span><\/p>\n

Vai tr\u00f2 c\u1ee7a n\u01b0\u1edbc DI trong ph\u00f2ng s\u1ea1ch<\/b><\/span><\/h4>\n

Trong quy tr\u00ecnh v\u1ec7 sinh ph\u00f2ng s\u1ea1ch, n\u01b0\u1edbc DI th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi ba vai tr\u00f2 ch\u00ednh:<\/span><\/p>\n

    \n
  1. Pha lo\u00e3ng h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n<\/b><\/li>\n<\/ol>\n

    N\u01b0\u1edbc DI c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 pha lo\u00e3ng c\u00e1c h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n \u0111\u1eadm \u0111\u1eb7c nh\u01b0 IPA ho\u1eb7c QUAT v\u1ec1 n\u1ed3ng \u0111\u1ed9 s\u1eed d\u1ee5ng theo <\/span>TDS (Technical Data Sheet)<\/b> c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t.<\/span><\/p>\n

      \n
    1. Tr\u00e1ng r\u1eeda ph\u00f2ng s\u1ea1ch v\u00e0 thi\u1ebft b\u1ecb<\/b><\/li>\n<\/ol>\n

      Sau qu\u00e1 tr\u00ecnh v\u1ec7 sinh ho\u1eb7c kh\u1eed khu\u1ea9n, n\u01b0\u1edbc DI c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 tr\u00e1ng r\u1eeda thi\u1ebft b\u1ecb ho\u1eb7c m\u1ed9t s\u1ed1 b\u1ec1 m\u1eb7t t\u00f9y theo y\u00eau c\u1ea7u c\u1ee7a t\u1eebng khu v\u1ef1c v\u00e0 quy tr\u00ecnh \u0111\u00e3 \u0111\u01b0\u1ee3c validation.<\/span><\/p>\n

        \n
      1. L\u00e0m \u01b0\u1edbt mop v\u00e0 wipe<\/b><\/li>\n<\/ol>\n

        N\u01b0\u1edbc DI c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m \u01b0\u1edbt d\u1ee5ng c\u1ee5 v\u1ec7 sinh tr\u01b0\u1edbc khi th\u1ef1c hi\u1ec7n b\u01b0\u1edbc l\u00e0m s\u1ea1ch c\u01a1 h\u1ecdc.<\/span><\/p>\n

        Nh\u01b0 v\u1eady, n\u01b0\u1edbc DI l\u00e0 m\u1ed9t <\/span>h\u1ea1 t\u1ea7ng h\u1ed7 tr\u1ee3 cho ch\u01b0\u01a1ng tr\u00ecnh v\u1ec7 sinh<\/b>, ch\u1ee9 kh\u00f4ng ph\u1ea3i m\u1ed9t t\u00e1c nh\u00e2n kh\u1eed khu\u1ea9n.<\/span><\/p>\n

        V\u00ec sao n\u01b0\u1edbc DI kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t kh\u1eed khu\u1ea9n?<\/b><\/span><\/h3>\n

        \u0110\u00e2y l\u00e0 \u0111i\u1ec3m quan tr\u1ecdng nh\u1ea5t khi \u0111\u00e1nh gi\u00e1 <\/span>\u1ee9ng d\u1ee5ng n\u01b0\u1edbc DI trong ph\u00f2ng s\u1ea1ch<\/b>.<\/span><\/p>\n

        Qu\u00e1 tr\u00ecnh kh\u1eed ion ch\u1ec9 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn c\u00e1c ion h\u00f2a tan trong n\u01b0\u1edbc. N\u00f3 <\/span>kh\u00f4ng c\u00f3 c\u01a1 ch\u1ebf di\u1ec7t khu\u1ea9n, b\u1ea5t ho\u1ea1t b\u00e0o t\u1eed ho\u1eb7c ph\u00e1 v\u1ee1 m\u00e0ng t\u1ebf b\u00e0o vi sinh v\u1eadt<\/b> gi\u1ed1ng nh\u01b0 IPA, QUAT ho\u1eb7c Hydrogen Peroxide.<\/span><\/p>\n

        N\u00f3i c\u00e1ch kh\u00e1c:<\/span><\/p>\n

        N\u01b0\u1edbc DI c\u00f3 \u0111\u1ed9 tinh khi\u1ebft ion cao kh\u00f4ng \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c n\u01b0\u1edbc DI c\u00f3 kh\u1ea3 n\u0103ng kh\u1eed khu\u1ea9n.<\/span><\/p>\n

        M\u1ed9t hi\u1ec3u l\u1ea7m ph\u1ed5 bi\u1ebfn l\u00e0 cho r\u1eb1ng n\u01b0\u1edbc DI kh\u00f4ng c\u00f3 nhi\u1ec1u ion v\u00e0 ch\u1ea5t dinh d\u01b0\u1ee1ng n\u00ean vi sinh v\u1eadt kh\u00f4ng th\u1ec3 t\u1ed3n t\u1ea1i trong \u0111\u00f3.<\/span><\/p>\n

        Tr\u00ean th\u1ef1c t\u1ebf, m\u1ed9t s\u1ed1 vi khu\u1ea9n <\/span>oligotrophic<\/b> c\u00f3 kh\u1ea3 n\u0103ng th\u00edch nghi v\u1edbi m\u00f4i tr\u01b0\u1eddng ngh\u00e8o dinh d\u01b0\u1ee1ng. C\u00e1c ch\u1ee7ng nh\u01b0 <\/span>Pseudomonas<\/b> ho\u1eb7c <\/span>Ralstonia<\/b> v\u1eabn c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i trong h\u1ec7 th\u1ed1ng n\u01b0\u1edbc DI.<\/span><\/p>\n

        \u0110\u1eb7c bi\u1ec7t, nguy c\u01a1 s\u1ebd t\u0103ng l\u00ean khi h\u1ec7 th\u1ed1ng c\u00f3:<\/span><\/p>\n

          \n
        • \u0110i\u1ec3m ch\u1ebft (dead-leg)<\/span><\/li>\n
        • \u0110o\u1ea1n \u1ed1ng \u00edt l\u01b0u th\u00f4ng<\/span><\/li>\n
        • Van \u00edt \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng<\/span><\/li>\n
        • Khu v\u1ef1c n\u01b0\u1edbc l\u01b0u gi\u1eef l\u00e2u<\/span><\/li>\n
        • Thi\u1ebft k\u1ebf tu\u1ea7n ho\u00e0n kh\u00f4ng ph\u00f9 h\u1ee3p<\/span><\/li>\n<\/ul>\n

          Nh\u1eefng \u0111i\u1ec1u ki\u1ec7n n\u00e0y c\u00f3 th\u1ec3 t\u1ea1o m\u00f4i tr\u01b0\u1eddng thu\u1eadn l\u1ee3i cho <\/span>biofilm<\/b> h\u00ecnh th\u00e0nh trong \u0111\u01b0\u1eddng \u1ed1ng.<\/span><\/p>\n

          N\u01b0\u1edbc DI ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c nh\u1eefng lo\u1ea1i vi sinh n\u00e0o?<\/b><\/span><\/h4>\n\n\n\n\n\n\n\n\n
          \u0110\u1ed1i t\u01b0\u1ee3ng vi sinh<\/b><\/td>\nKh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t c\u1ee7a n\u01b0\u1edbc DI<\/b><\/td>\n<\/tr>\n
          Vi khu\u1ea9n d\u1ea1ng sinh d\u01b0\u1ee1ng<\/span><\/td>\nKh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t<\/span><\/td>\n<\/tr>\n
          Vi khu\u1ea9n oligotrophic nh\u01b0 Pseudomonas, Ralstonia<\/span><\/td>\nKh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t<\/span><\/td>\n<\/tr>\n
          B\u00e0o t\u1eed vi khu\u1ea9n<\/span><\/td>\nKh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t<\/span><\/td>\n<\/tr>\n
          N\u1ea5m m\u1ed1c, n\u1ea5m men<\/span><\/td>\nKh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t<\/span><\/td>\n<\/tr>\n
          Biofilm trong \u0111\u01b0\u1eddng \u1ed1ng<\/span><\/td>\nKh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          V\u00ec v\u1eady, <\/span>n\u01b0\u1edbc DI n\u00ean \u0111\u01b0\u1ee3c xem l\u00e0 h\u1ea1 t\u1ea7ng h\u1ed7 tr\u1ee3 v\u1ec7 sinh, kh\u00f4ng ph\u1ea3i m\u1ed9t b\u01b0\u1edbc kh\u1eed khu\u1ea9n \u0111\u1ed9c l\u1eadp<\/b>.<\/span><\/p>\n

          N\u1ebfu n\u01b0\u1edbc DI \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 tr\u00e1ng r\u1eeda sau kh\u1eed khu\u1ea9n, h\u1ec7 th\u1ed1ng n\u01b0\u1edbc v\u1eabn c\u1ea7n c\u00f3 ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 vi sinh ri\u00eang.<\/span><\/p>\n

          H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng n\u01b0\u1edbc DI trong ph\u00f2ng s\u1ea1ch GMP<\/b><\/span><\/h3>\n

          \u1ee8ng d\u1ee5ng n\u01b0\u1edbc DI c\u1ea7n \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh d\u1ef1a tr\u00ean <\/span>c\u1ea5p \u0111\u1ed9 ph\u00f2ng s\u1ea1ch, m\u1ee9c \u0111\u1ed9 r\u1ee7i ro v\u00e0 y\u00eau c\u1ea7u c\u1ee7a t\u1eebng quy tr\u00ecnh<\/b>.<\/span><\/p>\n

          Kh\u00f4ng n\u00ean \u00e1p d\u1ee5ng m\u1ed9t ti\u00eau chu\u1ea9n s\u1eed d\u1ee5ng n\u01b0\u1edbc DI gi\u1ed1ng nhau cho t\u1ea5t c\u1ea3 c\u00e1c khu v\u1ef1c.<\/span><\/p>\n

          \u1ee8ng d\u1ee5ng n\u01b0\u1edbc DI theo khu v\u1ef1c ph\u00f2ng s\u1ea1ch<\/b><\/h3>\n\n\n\n\n\n\n\n
          Khu v\u1ef1c<\/b><\/td>\n\u1ee8ng d\u1ee5ng n\u01b0\u1edbc DI<\/b><\/td>\n<\/tr>\n
          Grade A<\/span><\/td>\nTh\u01b0\u1eddng kh\u00f4ng s\u1eed d\u1ee5ng cho tr\u00e1ng r\u1eeda cu\u1ed1i tr\u00ean b\u1ec1 m\u1eb7t ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi s\u1ea3n ph\u1ea9m; \u01b0u ti\u00ean WFI ho\u1eb7c lo\u1ea1i n\u01b0\u1edbc \u0111\u1ea1t ti\u00eau chu\u1ea9n cao h\u01a1n theo y\u00eau c\u1ea7u n\u1ed9i b\u1ed9<\/span><\/td>\n<\/tr>\n
          Grade B<\/span><\/td>\nC\u00f3 th\u1ec3 s\u1eed d\u1ee5ng cho pha h\u00f3a ch\u1ea5t ho\u1eb7c tr\u00e1ng s\u01a1 b\u1ed9; vi\u1ec7c s\u1eed d\u1ee5ng cho tr\u00e1ng cu\u1ed1i ph\u1ee5 thu\u1ed9c validation<\/span><\/td>\n<\/tr>\n
          Grade C<\/span><\/td>\nC\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ec3 pha h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n v\u00e0 tr\u00e1ng r\u1eeda thi\u1ebft b\u1ecb, b\u1ec1 m\u1eb7t kh\u00f4ng ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi s\u1ea3n ph\u1ea9m<\/span><\/td>\n<\/tr>\n
          Grade D<\/span><\/td>\nC\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ec3 pha h\u00f3a ch\u1ea5t, l\u00e0m \u01b0\u1edbt mop v\u00e0 th\u1ef1c hi\u1ec7n v\u1ec7 sinh c\u01a1 h\u1ecdc ban \u0111\u1ea7u<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          \u0110i\u1ec3m c\u1ea7n l\u01b0u \u00fd l\u00e0 <\/span>Grade kh\u00f4ng ph\u1ea3i y\u1ebfu t\u1ed1 duy nh\u1ea5t quy\u1ebft \u0111\u1ecbnh lo\u1ea1i n\u01b0\u1edbc \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng<\/b>. SOP, validation, y\u00eau c\u1ea7u s\u1ea3n ph\u1ea9m v\u00e0 ti\u00eau chu\u1ea9n n\u1ed9i b\u1ed9 c\u1ee7a t\u1eebng nh\u00e0 m\u00e1y v\u1eabn ph\u1ea3i \u0111\u01b0\u1ee3c xem x\u00e9t.<\/span><\/p>\n

          Quy tr\u00ecnh s\u1eed d\u1ee5ng n\u01b0\u1edbc DI tham kh\u1ea3o<\/b><\/span><\/h4>\n

          M\u1ed9t quy tr\u00ecnh s\u1eed d\u1ee5ng n\u01b0\u1edbc DI trong v\u1ec7 sinh ph\u00f2ng s\u1ea1ch c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c tri\u1ec3n khai theo c\u00e1c b\u01b0\u1edbc:<\/span><\/p>\n

          B\u01b0\u1edbc 1: Ki\u1ec3m tra ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc t\u1ea1i POU<\/b><\/p>\n

          Tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng, c\u1ea7n ki\u1ec3m tra c\u00e1c th\u00f4ng s\u1ed1 \u0111\u01b0\u1ee3c quy \u0111\u1ecbnh trong h\u1ec7 th\u1ed1ng ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng, ch\u1eb3ng h\u1ea1n nh\u01b0 <\/span>conductivity v\u00e0 TOC (Total Organic Carbon)<\/b> t\u1ea1i \u0111i\u1ec3m s\u1eed d\u1ee5ng.<\/span><\/p>\n

          B\u01b0\u1edbc 2: Pha h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n<\/b><\/p>\n

          S\u1eed d\u1ee5ng n\u01b0\u1edbc DI \u0111\u1ec3 pha lo\u00e3ng h\u00f3a ch\u1ea5t theo \u0111\u00fang t\u1ef7 l\u1ec7 \u0111\u01b0\u1ee3c quy \u0111\u1ecbnh trong TDS.<\/span><\/p>\n

          Th\u00f4ng tin v\u1ec1 l\u00f4 n\u01b0\u1edbc DI v\u00e0 h\u00f3a ch\u1ea5t c\u1ea7n \u0111\u01b0\u1ee3c ghi nh\u1eadn theo SOP n\u1ebfu quy tr\u00ecnh n\u1ed9i b\u1ed9 y\u00eau c\u1ea7u.<\/span><\/p>\n

          B\u01b0\u1edbc 3: Th\u1ef1c hi\u1ec7n kh\u1eed khu\u1ea9n<\/b><\/p>\n

          Ti\u1ebfn h\u00e0nh kh\u1eed khu\u1ea9n b\u1ec1 m\u1eb7t theo SOP hi\u1ec7n h\u00e0nh, \u0111\u1ea3m b\u1ea3o \u0111\u00fang n\u1ed3ng \u0111\u1ed9 v\u00e0 th\u1eddi gian ti\u1ebfp x\u00fac.<\/span><\/p>\n

          N\u1ebfu nh\u00e0 m\u00e1y \u00e1p d\u1ee5ng ch\u01b0\u01a1ng tr\u00ecnh <\/span>lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n<\/b>, c\u1ea7n tu\u00e2n th\u1ee7 \u0111\u00fang l\u1ecbch s\u1eed d\u1ee5ng IPA, QUAT, H2O2 ho\u1eb7c sporicide theo quy \u0111\u1ecbnh.<\/span><\/p>\n

          B\u01b0\u1edbc 4: Tr\u00e1ng r\u1eeda<\/b><\/p>\n

          Th\u1ef1c hi\u1ec7n tr\u00e1ng r\u1eeda b\u1eb1ng n\u01b0\u1edbc DI n\u1ebfu quy tr\u00ecnh cho ph\u00e9p, \u0111\u1ed3ng th\u1eddi ki\u1ec3m so\u00e1t th\u1eddi gian v\u00e0 tr\u00e1nh \u0111\u1ec3 n\u01b0\u1edbc \u0111\u1ecdng tr\u00ean b\u1ec1 m\u1eb7t.<\/span><\/p>\n

          B\u01b0\u1edbc 5: Theo d\u00f5i ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc<\/b><\/p>\n

          K\u1ebft qu\u1ea3 ki\u1ec3m tra vi sinh t\u1ea1i \u0111i\u1ec3m s\u1eed d\u1ee5ng c\u1ea7n \u0111\u01b0\u1ee3c ghi nh\u1eadn trong ch\u01b0\u01a1ng tr\u00ecnh <\/span>Environmental Monitoring (EM)<\/b> ho\u1eb7c ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m so\u00e1t n\u01b0\u1edbc t\u01b0\u01a1ng \u1ee9ng c\u1ee7a nh\u00e0 m\u00e1y.<\/span><\/p>\n

          5 l\u1ed7i ph\u1ed5 bi\u1ebfn khi s\u1eed d\u1ee5ng n\u01b0\u1edbc DI trong ph\u00f2ng s\u1ea1ch<\/b><\/span><\/h3>\n

          1. Nh\u1ea7m n\u01b0\u1edbc DI c\u00f3 kh\u1ea3 n\u0103ng kh\u1eed khu\u1ea9n<\/b><\/span><\/h4>\n

          \u0110\u00e2y l\u00e0 l\u1ed7i nh\u1eadn th\u1ee9c ph\u1ed5 bi\u1ebfn nh\u1ea5t.<\/span><\/p>\n

          Do n\u01b0\u1edbc DI c\u00f3 \u0111\u1ed9 d\u1eabn \u0111i\u1ec7n th\u1ea5p v\u00e0 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u201cn\u01b0\u1edbc kh\u1eed ion\u201d, m\u1ed9t s\u1ed1 ng\u01b0\u1eddi c\u00f3 th\u1ec3 hi\u1ec3u nh\u1ea7m r\u1eb1ng n\u01b0\u1edbc \u0111\u00e3 \u0111\u01b0\u1ee3c l\u00e0m s\u1ea1ch \u0111\u1ebfn m\u1ee9c c\u00f3 th\u1ec3 thay th\u1ebf h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n.<\/span><\/p>\n

          Tuy nhi\u00ean, <\/span>n\u01b0\u1edbc DI kh\u00f4ng ph\u1ea3i ch\u1ea5t kh\u1eed khu\u1ea9n<\/b>.<\/span><\/p>\n

          N\u1ebfu s\u1eed d\u1ee5ng DI thay th\u1ebf cho b\u01b0\u1edbc kh\u1eed khu\u1ea9n, b\u1ec1 m\u1eb7t c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t vi sinh \u0111\u1ea7y \u0111\u1ee7, t\u1eeb \u0111\u00f3 l\u00e0m t\u0103ng nguy c\u01a1 sai l\u1ec7ch trong ch\u01b0\u01a1ng tr\u00ecnh EM.<\/span><\/p>\n

          2. Kh\u00f4ng gi\u00e1m s\u00e1t vi sinh c\u1ee7a h\u1ec7 th\u1ed1ng n\u01b0\u1edbc DI<\/b><\/span><\/h4>\n

          M\u1ed9t h\u1ec7 th\u1ed1ng n\u01b0\u1edbc DI c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u1ed9 d\u1eabn \u0111i\u1ec7n r\u1ea5t th\u1ea5p nh\u01b0ng v\u1eabn t\u1ed3n t\u1ea1i vi sinh v\u1eadt.<\/span><\/p>\n

          N\u1ebfu h\u1ec7 th\u1ed1ng l\u01b0u tr\u1eef v\u00e0 tu\u1ea7n ho\u00e0n kh\u00f4ng \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t, biofilm c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh t\u1ea1i c\u00e1c \u0111i\u1ec3m ch\u1ebft ho\u1eb7c khu v\u1ef1c \u00edt l\u01b0u th\u00f4ng.<\/span><\/p>\n

          Khi \u0111\u00f3, n\u01b0\u1edbc \u0111\u01b0\u1ee3c l\u1ea5y t\u1ea1i m\u1ed9t POU c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh ngu\u1ed3n nhi\u1ec5m ch\u00e9o cho c\u00e1c khu v\u1ef1c s\u1eed d\u1ee5ng n\u01b0\u1edbc.<\/span><\/p>\n

          3. S\u1eed d\u1ee5ng n\u01b0\u1edbc DI kh\u00f4ng \u0111\u1ea1t specification \u0111\u1ec3 pha h\u00f3a ch\u1ea5t<\/b><\/span><\/h4>\n

          Ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc t\u1ea1i POU c\u1ea7n \u0111\u00e1p \u1ee9ng specification \u0111\u01b0\u1ee3c quy \u0111\u1ecbnh trong TDS c\u1ee7a h\u00f3a ch\u1ea5t.<\/span><\/p>\n

          N\u1ebfu conductivity ho\u1eb7c TOC v\u01b0\u1ee3t ng\u01b0\u1ee1ng cho ph\u00e9p nh\u01b0ng n\u01b0\u1edbc v\u1eabn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 pha h\u00f3a ch\u1ea5t, ch\u1ea5t l\u01b0\u1ee3ng dung d\u1ecbch sau pha c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1ea1t y\u00eau c\u1ea7u.<\/span><\/p>\n

          \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 d\u00f9 nh\u00e2n vi\u00ean v\u1eabn th\u1ef1c hi\u1ec7n \u0111\u00fang t\u1ef7 l\u1ec7 pha tr\u00ean gi\u1ea5y t\u1edd, hi\u1ec7u qu\u1ea3 c\u1ee7a dung d\u1ecbch kh\u1eed khu\u1ea9n v\u1eabn c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng.<\/span><\/p>\n

          4. Ch\u1ec9 ki\u1ec3m tra conductivity\/TOC khi x\u1ea3y ra s\u1ef1 c\u1ed1<\/b><\/span><\/h4>\n

          Conductivity v\u00e0 TOC kh\u00f4ng n\u00ean ch\u1ec9 \u0111\u01b0\u1ee3c ki\u1ec3m tra sau khi \u0111\u00e3 x\u1ea3y ra v\u1ea5n \u0111\u1ec1.<\/span><\/p>\n

          Vi\u1ec7c theo d\u00f5i \u0111\u1ecbnh k\u1ef3 gi\u00fap ph\u00e1t hi\u1ec7n xu h\u01b0\u1edbng suy gi\u1ea3m ch\u1ea5t l\u01b0\u1ee3ng h\u1ec7 th\u1ed1ng, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1ef1 thay \u0111\u1ed5i b\u1ea5t th\u01b0\u1eddng c\u1ee7a conductivity ho\u1eb7c TOC.<\/span><\/p>\n

          \u0110\u00e2y c\u00f3 th\u1ec3 l\u00e0 d\u1ea5u hi\u1ec7u cho th\u1ea5y h\u1ec7 th\u1ed1ng x\u1eed l\u00fd n\u01b0\u1edbc ho\u1eb7c resin c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1.<\/span><\/p>\n

          5. D\u00f9ng n\u01b0\u1edbc DI cho khu v\u1ef1c y\u00eau c\u1ea7u n\u01b0\u1edbc c\u00f3 c\u1ea5p \u0111\u1ed9 cao h\u01a1n<\/b><\/span><\/h4>\n

          Kh\u00f4ng n\u00ean m\u1eb7c \u0111\u1ecbnh n\u01b0\u1edbc DI c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng cho m\u1ecdi khu v\u1ef1c.<\/span><\/p>\n

          \u0110\u1eb7c bi\u1ec7t t\u1ea1i c\u00e1c khu v\u1ef1c c\u00f3 y\u00eau c\u1ea7u nghi\u00eam ng\u1eb7t v\u1ec1 ki\u1ec3m so\u00e1t nhi\u1ec5m v\u00e0 b\u1ec1 m\u1eb7t ti\u1ebfp x\u00fac s\u1ea3n ph\u1ea9m, lo\u1ea1i n\u01b0\u1edbc s\u1eed d\u1ee5ng ph\u1ea3i ph\u00f9 h\u1ee3p v\u1edbi SOP, validation v\u00e0 y\u00eau c\u1ea7u GMP c\u1ee7a c\u01a1 s\u1edf.<\/span><\/p>\n

          Vi\u1ec7c t\u1ef1 \u00fd thay DI cho PW ho\u1eb7c WFI v\u00ec l\u00fd do ti\u1ec7n d\u1ee5ng ho\u1eb7c thi\u1ebfu ngu\u1ed3n cung c\u00f3 th\u1ec3 t\u1ea1o ra sai l\u1ec7ch trong quy tr\u00ecnh.<\/span><\/p>\n

          So s\u00e1nh n\u01b0\u1edbc DI v\u1edbi PW, WFI v\u00e0 RO<\/b><\/span><\/h3>\n

          Trong h\u1ec7 th\u1ed1ng n\u01b0\u1edbc s\u1eed d\u1ee5ng cho ph\u00f2ng s\u1ea1ch GMP, n\u01b0\u1edbc DI th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u0111\u1eb7t c\u1ea1nh <\/span>Purified Water (PW), Water For Injection (WFI)<\/b> v\u00e0 n\u01b0\u1edbc RO.<\/span><\/p>\n

          M\u1eb7c d\u00f9 \u0111\u1ec1u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c h\u1ec7 th\u1ed1ng x\u1eed l\u00fd n\u01b0\u1edbc, ch\u00fang c\u00f3 ph\u01b0\u01a1ng ph\u00e1p x\u1eed l\u00fd v\u00e0 m\u1ee5c \u0111\u00edch s\u1eed d\u1ee5ng kh\u00e1c nhau.<\/span><\/p>\n\n\n\n\n\n\n\n
          Ti\u00eau ch\u00ed<\/b><\/td>\nN\u01b0\u1edbc DI<\/b><\/td>\nPurified Water (PW)<\/b><\/td>\nWFI<\/b><\/td>\nN\u01b0\u1edbc RO<\/b><\/td>\n<\/tr>\n
          Ph\u01b0\u01a1ng ph\u00e1p x\u1eed l\u00fd<\/span><\/td>\nTrao \u0111\u1ed5i ion<\/span><\/td>\nRO k\u1ebft h\u1ee3p kh\u1eed ion, UV\/l\u1ecdc tinh<\/span><\/td>\nCh\u01b0ng c\u1ea5t ho\u1eb7c RO k\u1ebft h\u1ee3p si\u00eau l\u1ecdc<\/span><\/td>\nTh\u1ea9m th\u1ea5u ng\u01b0\u1ee3c qua m\u00e0ng<\/span><\/td>\n<\/tr>\n
          \u0110\u1ed9 d\u1eabn \u0111i\u1ec7n<\/span><\/td>\nTh\u1ea5p, t\u00f9y thi\u1ebft k\u1ebf h\u1ec7 th\u1ed1ng<\/span><\/td>\nKi\u1ec3m so\u00e1t theo d\u01b0\u1ee3c \u0111i\u1ec3n<\/span><\/td>\nKi\u1ec3m so\u00e1t nghi\u00eam ng\u1eb7t<\/span><\/td>\nPh\u1ee5 thu\u1ed9c ch\u1ea5t l\u01b0\u1ee3ng ngu\u1ed3n<\/span><\/td>\n<\/tr>\n
          Ki\u1ec3m so\u00e1t n\u1ed9i \u0111\u1ed9c t\u1ed1<\/span><\/td>\nKh\u00f4ng quy \u0111\u1ecbnh ri\u00eang<\/span><\/td>\nT\u00f9y y\u00eau c\u1ea7u ti\u00eau chu\u1ea9n \u00e1p d\u1ee5ng<\/span><\/td>\nKi\u1ec3m so\u00e1t nghi\u00eam ng\u1eb7t<\/span><\/td>\nKh\u00f4ng quy \u0111\u1ecbnh ri\u00eang<\/span><\/td>\n<\/tr>\n
          \u1ee8ng d\u1ee5ng<\/span><\/td>\nPha h\u00f3a ch\u1ea5t, tr\u00e1ng r\u1eeda t\u00f9y khu v\u1ef1c<\/span><\/td>\nPha ch\u1ebf, tr\u00e1ng r\u1eeda theo y\u00eau c\u1ea7u<\/span><\/td>\nC\u00e1c \u1ee9ng d\u1ee5ng y\u00eau c\u1ea7u c\u1ea5p \u0111\u1ed9 n\u01b0\u1edbc cao<\/span><\/td>\nTh\u01b0\u1eddng l\u00e0 ngu\u1ed3n c\u1ea5p trung gian<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          DI Water v\u00e0 RO Water kh\u00e1c nhau nh\u01b0 th\u1ebf n\u00e0o?<\/b><\/span><\/h4>\n

          N\u01b0\u1edbc RO<\/b> \u0111\u01b0\u1ee3c x\u1eed l\u00fd ch\u1ee7 y\u1ebfu th\u00f4ng qua m\u00e0ng th\u1ea9m th\u1ea5u ng\u01b0\u1ee3c. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf nhi\u1ec1u lo\u1ea1i t\u1ea1p ch\u1ea5t, bao g\u1ed3m m\u1ed9t ph\u1ea7n ion, ch\u1ea5t h\u1eefu c\u01a1 v\u00e0 vi sinh v\u1eadt.<\/span><\/p>\n

          Trong khi \u0111\u00f3, <\/span>DI t\u1eadp trung v\u00e0o vi\u1ec7c lo\u1ea1i b\u1ecf ion h\u00f2a tan th\u00f4ng qua qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ion<\/b>.<\/span><\/p>\n

          V\u00ec v\u1eady, RO v\u00e0 DI kh\u00f4ng ph\u1ea3i hai kh\u00e1i ni\u1ec7m ho\u00e0n to\u00e0n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng.<\/span><\/p>\n

          Trong th\u1ef1c t\u1ebf, m\u1ed9t h\u1ec7 th\u1ed1ng x\u1eed l\u00fd n\u01b0\u1edbc c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng <\/span>RO l\u00e0m b\u01b0\u1edbc x\u1eed l\u00fd s\u01a1 b\u1ed9 tr\u01b0\u1edbc khi \u0111\u01b0a n\u01b0\u1edbc qua h\u1ec7 th\u1ed1ng DI<\/b>.<\/span><\/p>\n

          DI Water v\u00e0 Purified Water kh\u00e1c nhau nh\u01b0 th\u1ebf n\u00e0o?<\/b><\/span><\/h4>\n

          Purified Water (PW) l\u00e0 n\u01b0\u1edbc \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t theo ti\u00eau chu\u1ea9n d\u01b0\u1ee3c \u0111i\u1ec3n t\u01b0\u01a1ng \u1ee9ng v\u00e0 c\u00f3 y\u00eau c\u1ea7u v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng to\u00e0n di\u1ec7n h\u01a1n ch\u1ec9 s\u1ed1 kh\u1eed ion.<\/span><\/p>\n

          Do \u0111\u00f3, kh\u00f4ng n\u00ean xem <\/span>n\u01b0\u1edbc DI = Purified Water<\/b> ch\u1ec9 v\u00ec c\u1ea3 hai \u0111\u1ec1u c\u00f3 \u0111\u1ed9 d\u1eabn \u0111i\u1ec7n th\u1ea5p.<\/span><\/p>\n

          Vi\u1ec7c s\u1eed d\u1ee5ng lo\u1ea1i n\u01b0\u1edbc n\u00e0o ph\u1ea3i d\u1ef1a tr\u00ean ti\u00eau chu\u1ea9n \u00e1p d\u1ee5ng v\u00e0 m\u1ee5c \u0111\u00edch s\u1eed d\u1ee5ng c\u1ee5 th\u1ec3.<\/span><\/p>\n

          DI Water v\u00e0 WFI kh\u00e1c nhau nh\u01b0 th\u1ebf n\u00e0o?<\/b><\/span><\/h4>\n

          Water For Injection (WFI)<\/b> c\u00f3 y\u00eau c\u1ea7u ki\u1ec3m so\u00e1t nghi\u00eam ng\u1eb7t h\u01a1n, \u0111\u1eb7c bi\u1ec7t li\u00ean quan \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng vi sinh v\u00e0 n\u1ed9i \u0111\u1ed9c t\u1ed1.<\/span><\/p>\n

          Do \u0111\u00f3, WFI \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho nh\u1eefng \u1ee9ng d\u1ee5ng c\u00f3 y\u00eau c\u1ea7u cao h\u01a1n v\u1ec1 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc.<\/span><\/p>\n

          N\u01b0\u1edbc DI kh\u00f4ng n\u00ean \u0111\u01b0\u1ee3c m\u1eb7c \u0111\u1ecbnh thay th\u1ebf WFI.<\/span><\/p>\n

          N\u01b0\u1edbc DI c\u00f3 li\u00ean quan g\u00ec \u0111\u1ebfn ch\u01b0\u01a1ng tr\u00ecnh lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n?<\/b><\/span><\/h3>\n

          C\u1ea7n ph\u00e2n bi\u1ec7t r\u00f5 hai v\u1ea5n \u0111\u1ec1:<\/span><\/p>\n

          N\u01b0\u1edbc DI kh\u00f4ng ph\u1ea3i h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n v\u00e0 kh\u00f4ng tham gia v\u00e0o c\u01a1 ch\u1ebf lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t.<\/b><\/p>\n

          Ch\u01b0\u01a1ng tr\u00ecnh lu\u00e2n phi\u00ean th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn c\u00e1c ho\u1ea1t ch\u1ea5t nh\u01b0:<\/span><\/p>\n

            \n
          • IPA<\/span><\/li>\n
          • QUAT<\/span><\/li>\n
          • Hydrogen Peroxide<\/span><\/li>\n
          • Sporicide<\/span><\/li>\n<\/ul>\n

            M\u1ee5c \u0111\u00edch c\u1ee7a vi\u1ec7c lu\u00e2n phi\u00ean l\u00e0 ki\u1ec3m so\u00e1t ph\u1ed5 vi sinh v\u00e0 gi\u1ea3m nguy c\u01a1 h\u00ecnh th\u00e0nh kh\u1ea3 n\u0103ng th\u00edch nghi \u0111\u1ed1i v\u1edbi m\u1ed9t nh\u00f3m ho\u1ea1t ch\u1ea5t.<\/span><\/p>\n

            Trong khi \u0111\u00f3, n\u01b0\u1edbc DI \u0111\u00f3ng vai tr\u00f2 h\u1ed7 tr\u1ee3:<\/span><\/p>\n

            N\u01b0\u1edbc DI \u2192 pha lo\u00e3ng h\u00f3a ch\u1ea5t \u2192 kh\u1eed khu\u1ea9n \u2192 tr\u00e1ng r\u1eeda<\/b><\/p>\n

            Do \u0111\u00f3, ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc DI v\u00e0 ch\u01b0\u01a1ng tr\u00ecnh lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t c\u1ea7n \u0111\u01b0\u1ee3c xem l\u00e0 <\/span>hai y\u1ebfu t\u1ed1 song song<\/b>.<\/span><\/p>\n

            M\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh lu\u00e2n phi\u00ean h\u00f3a ch\u1ea5t \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng t\u1ed1t v\u1eabn c\u00f3 th\u1ec3 g\u1eb7p v\u1ea5n \u0111\u1ec1 n\u1ebfu ngu\u1ed3n n\u01b0\u1edbc d\u00f9ng \u0111\u1ec3 pha ho\u1eb7c tr\u00e1ng r\u1eeda kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t.<\/span><\/p>\n

            Ki\u1ec3m so\u00e1t vi sinh n\u01b0\u1edbc DI trong ph\u00f2ng s\u1ea1ch<\/b><\/span><\/h3>\n

            M\u1ed9t trong nh\u1eefng r\u1ee7i ro l\u1edbn nh\u1ea5t c\u1ee7a h\u1ec7 th\u1ed1ng n\u01b0\u1edbc DI l\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a vi sinh v\u1eadt trong \u0111\u01b0\u1eddng \u1ed1ng v\u00e0 h\u1ec7 th\u1ed1ng ph\u00e2n ph\u1ed1i.<\/span><\/p>\n

            T\u1ea1i sao vi sinh c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i trong n\u01b0\u1edbc DI?<\/b><\/h3>\n

            \u0110\u1ed9 d\u1eabn \u0111i\u1ec7n th\u1ea5p ch\u1ec9 ph\u1ea3n \u00e1nh l\u01b0\u1ee3ng ion h\u00f2a tan trong n\u01b0\u1edbc.<\/span><\/p>\n

            N\u00f3 <\/span>kh\u00f4ng ph\u1ea3i ch\u1ec9 s\u1ed1 tr\u1ef1c ti\u1ebfp ph\u1ea3n \u00e1nh s\u1ed1 l\u01b0\u1ee3ng vi sinh v\u1eadt<\/b>.<\/span><\/p>\n

            V\u00ec v\u1eady, m\u1ed9t m\u1eabu n\u01b0\u1edbc DI c\u00f3 conductivity r\u1ea5t th\u1ea5p v\u1eabn c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i vi sinh v\u1eadt.<\/span><\/p>\n

            \u0110\u1eb7c bi\u1ec7t, c\u00e1c vi khu\u1ea9n oligotrophic c\u00f3 kh\u1ea3 n\u0103ng th\u00edch nghi v\u1edbi m\u00f4i tr\u01b0\u1eddng ngh\u00e8o dinh d\u01b0\u1ee1ng v\u00e0 c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i trong h\u1ec7 th\u1ed1ng n\u01b0\u1edbc.<\/span><\/p>\n

            Nh\u1eefng v\u1ecb tr\u00ed c\u1ea7n ch\u00fa \u00fd<\/b><\/h4>\n

            Khi \u0111\u00e1nh gi\u00e1 h\u1ec7 th\u1ed1ng n\u01b0\u1edbc DI, c\u1ea7n \u0111\u1eb7c bi\u1ec7t l\u01b0u \u00fd:<\/span><\/p>\n

              \n
            • Dead-leg<\/span><\/li>\n
            • \u0110i\u1ec3m s\u1eed d\u1ee5ng \u00edt th\u01b0\u1eddng xuy\u00ean<\/span><\/li>\n
            • Van \u00edt s\u1eed d\u1ee5ng<\/span><\/li>\n
            • \u0110\u01b0\u1eddng \u1ed1ng c\u00f3 l\u01b0u l\u01b0\u1ee3ng th\u1ea5p<\/span><\/li>\n
            • B\u1ed3n ch\u1ee9a<\/span><\/li>\n
            • Khu v\u1ef1c n\u01b0\u1edbc l\u01b0u tr\u1eef<\/span><\/li>\n
            • C\u00e1c \u0111o\u1ea1n kh\u00f4ng \u0111\u01b0\u1ee3c tu\u1ea7n ho\u00e0n li\u00ean t\u1ee5c<\/span><\/li>\n<\/ul>\n

              N\u1ebfu biofilm h\u00ecnh th\u00e0nh, vi\u1ec7c ch\u1ec9 ki\u1ec3m tra conductivity s\u1ebd kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ph\u00e1t hi\u1ec7n v\u1ea5n \u0111\u1ec1.<\/span><\/p>\n

              Do \u0111\u00f3, h\u1ec7 th\u1ed1ng c\u1ea7n \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1eb1ng ch\u01b0\u01a1ng tr\u00ecnh ph\u00f9 h\u1ee3p v\u1edbi thi\u1ebft k\u1ebf v\u00e0 m\u1ee9c \u0111\u1ed9 r\u1ee7i ro.<\/span><\/p>\n

              FAQs – \u1ee8ng d\u1ee5ng n\u01b0\u1edbc DI<\/b><\/span><\/h3>\n
              \n

              N\u01b0\u1edbc DI c\u00f3 c\u1ea7n ki\u1ec3m tra vi sinh \u0111\u1ecbnh k\u1ef3 kh\u00f4ng?<\/b><\/h4>\n

              C\u00f3.<\/b><\/p>\n

              M\u1eb7c d\u00f9 n\u01b0\u1edbc DI kh\u00f4ng ph\u1ea3i ch\u1ea5t kh\u1eed khu\u1ea9n, h\u1ec7 th\u1ed1ng n\u01b0\u1edbc v\u1eabn c\u00f3 nguy c\u01a1 nhi\u1ec5m vi sinh v\u00e0 h\u00ecnh th\u00e0nh biofilm.<\/span><\/p>\n

              Vi\u1ec7c ki\u1ec3m tra c\u00f3 th\u1ec3 bao g\u1ed3m bioburden c\u00f9ng v\u1edbi c\u00e1c th\u00f4ng s\u1ed1 ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc nh\u01b0 TOC v\u00e0 conductivity t\u1ea1i POU, t\u00f9y theo ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3m so\u00e1t c\u1ee7a t\u1eebng nh\u00e0 m\u00e1y.<\/span><\/p>\n

              N\u01b0\u1edbc DI c\u00f3 th\u1ec3 d\u00f9ng \u0111\u1ec3 pha IPA 70% ho\u1eb7c QUAT kh\u00f4ng?<\/b><\/h4>\n

              C\u00f3 th\u1ec3<\/b>, n\u1ebfu ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc t\u1ea1i POU \u0111\u00e1p \u1ee9ng specification \u0111\u01b0\u1ee3c quy \u0111\u1ecbnh trong TDS c\u1ee7a h\u00f3a ch\u1ea5t.<\/span><\/p>\n

              Kh\u00f4ng n\u00ean ch\u1ec9 d\u1ef1a v\u00e0o t\u00ean g\u1ecdi \u201cn\u01b0\u1edbc DI\u201d \u0111\u1ec3 m\u1eb7c \u0111\u1ecbnh r\u1eb1ng n\u01b0\u1edbc lu\u00f4n ph\u00f9 h\u1ee3p cho m\u1ecdi lo\u1ea1i h\u00f3a ch\u1ea5t.<\/span><\/p>\n

              \u0110\u1ed9 d\u1eabn \u0111i\u1ec7n n\u01b0\u1edbc DI th\u1ea5p c\u00f3 \u0111\u1ed3ng ngh\u0129a v\u1edbi n\u01b0\u1edbc kh\u00f4ng c\u00f3 vi sinh kh\u00f4ng?<\/b><\/h4>\n

              Kh\u00f4ng.<\/b><\/p>\n

              Conductivity ph\u1ea3n \u00e1nh m\u1ee9c ion h\u00f2a tan trong n\u01b0\u1edbc, kh\u00f4ng ph\u1ea3i m\u1ee9c \u0111\u1ed9 nhi\u1ec5m vi sinh.<\/span><\/p>\n

              Do \u0111\u00f3, conductivity th\u1ea5p kh\u00f4ng th\u1ec3 thay th\u1ebf cho vi\u1ec7c ki\u1ec3m so\u00e1t microbiological quality.<\/span><\/p>\n

              V\u00ec sao n\u01b0\u1edbc DI c\u00f3 th\u1ec3 nhi\u1ec5m Pseudomonas?<\/b><\/h4>\n

              M\u1ed9t s\u1ed1 vi khu\u1ea9n oligotrophic c\u00f3 kh\u1ea3 n\u0103ng t\u1ed3n t\u1ea1i trong m\u00f4i tr\u01b0\u1eddng ngh\u00e8o dinh d\u01b0\u1ee1ng.<\/span><\/p>\n

              N\u1ebfu h\u1ec7 th\u1ed1ng c\u00f3 dead-leg ho\u1eb7c khu v\u1ef1c n\u01b0\u1edbc \u00edt l\u01b0u th\u00f4ng, vi sinh v\u1eadt c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i v\u00e0 ph\u00e1t tri\u1ec3n th\u00e0nh biofilm.<\/span><\/p>\n

              N\u01b0\u1edbc DI c\u00f3 th\u1ec3 d\u00f9ng \u0111\u1ec3 tr\u00e1ng r\u1eeda cu\u1ed1i \u1edf Grade B kh\u00f4ng?<\/b><\/h4>\n

              \u0110i\u1ec1u n\u00e0y <\/span>ph\u1ee5 thu\u1ed9c v\u00e0o validation v\u00e0 y\u00eau c\u1ea7u n\u1ed9i b\u1ed9 c\u1ee7a t\u1eebng nh\u00e0 m\u00e1y<\/b>.<\/span><\/p>\n

              M\u1ed9t c\u01a1 s\u1edf c\u00f3 th\u1ec3 ch\u1ea5p nh\u1eadn DI cho tr\u00e1ng s\u01a1 b\u1ed9 nh\u01b0ng y\u00eau c\u1ea7u PW ho\u1eb7c lo\u1ea1i n\u01b0\u1edbc cao h\u01a1n cho b\u01b0\u1edbc tr\u00e1ng cu\u1ed1i.<\/span><\/p>\n

              V\u00ec v\u1eady, kh\u00f4ng n\u00ean \u00e1p d\u1ee5ng m\u1ed9t k\u1ebft lu\u1eadn chung cho t\u1ea5t c\u1ea3 c\u00e1c nh\u00e0 m\u00e1y.<\/span><\/p><\/blockquote>\n

              T\u1ea1m K\u1ebft<\/b><\/span><\/h3>\n

              \u1ee8ng d\u1ee5ng n\u01b0\u1edbc DI trong v\u1ec7 sinh ph\u00f2ng s\u1ea1ch<\/b> t\u1eadp trung ch\u1ee7 y\u1ebfu v\u00e0o vai tr\u00f2 h\u1ed7 tr\u1ee3: pha lo\u00e3ng h\u00f3a ch\u1ea5t kh\u1eed khu\u1ea9n, l\u00e0m \u01b0\u1edbt d\u1ee5ng c\u1ee5 v\u1ec7 sinh v\u00e0 tr\u00e1ng r\u1eeda trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c SOP v\u00e0 validation cho ph\u00e9p.<\/span><\/p>\n

              \u0110i\u1ec3m quan tr\u1ecdng nh\u1ea5t c\u1ea7n nh\u1edb l\u00e0:<\/span><\/p>\n

              N\u01b0\u1edbc DI l\u00e0 n\u01b0\u1edbc kh\u1eed ion, kh\u00f4ng ph\u1ea3i n\u01b0\u1edbc kh\u1eed khu\u1ea9n.<\/b><\/p>\n

              \u0110\u1ed9 d\u1eabn \u0111i\u1ec7n th\u1ea5p kh\u00f4ng \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c n\u01b0\u1edbc kh\u00f4ng c\u00f3 vi sinh. N\u1ebfu h\u1ec7 th\u1ed1ng n\u01b0\u1edbc c\u00f3 dead-leg, l\u01b0u l\u01b0\u1ee3ng th\u1ea5p ho\u1eb7c ki\u1ec3m so\u00e1t tu\u1ea7n ho\u00e0n kh\u00f4ng ph\u00f9 h\u1ee3p, vi sinh v\u1eadt v\u1eabn c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i v\u00e0 h\u00ecnh th\u00e0nh biofilm.<\/span><\/p>\n

              \u0110\u1ec3 s\u1eed d\u1ee5ng n\u01b0\u1edbc DI an to\u00e0n trong ph\u00f2ng s\u1ea1ch, doanh nghi\u1ec7p n\u00ean:<\/span><\/p>\n